SCH 79797 dihydrochloride
Grundinformationen
- CAS
1216720-69-2- Standard-SMILES
CC(C)c1ccc(Cn2ccc3c4c(N)nc(NC5CC5)nc4ccc32)cc1.Cl.Cl- InChIKey
NNJTXSQXGHYXAJ-UHFFFAOYSA-N- Summenformel
- C23H27Cl2N5
- Durchschnittliche Molmasse
- 444,4 g/mol
- Monoisotopische Masse
- 443,1643513
Namen und Bezeichner
- Bevorzugter Name
- SCH 79797 dihydrochloride
- IUPAC
- 3-N-cyclopropyl-7-[(4-propan-2-ylphenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine;dihydrochloride
- Englischer Name
- 7H-Pyrrolo[3,2-f]quinazoline-1,3-diaMine, N3-cyclopropyl-7-[[4-(1-Methylethyl)phenyl]Methyl]-, (Hydrochloride) (1:2)
- Summenformel
- C23H26ClN5
- Molmasse
- 407.95
Namen und Synonyme
1216720-69-2SCH 79797 dihydrochlorideSCH79797 dihydrochlorideSCH79797 (dihydrochloride)N3-Cyclopropyl-7-(4-isopropylbenzyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochlorideSCH79797 2HCl3-N-cyclopropyl-7-[(4-propan-2-ylphenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine;dihydrochlorideSCH 79797 2HClSCHEMBL17261836CS-0003684E987377H-Pyrrolo[3,2-f]quinazoline-1,3-diaMine, N3-cyclopropyl-7-[[4-(1-Methylethyl)phenyl]Methyl]-, (Hydr
Weitere Namen anzeigen
SCH 79797 (hydrochloride)SCH79797 dihydrochloride ，S9916SCH79797 dihydrochloride, PAR1 antagonist7H-Pyrrolo[3,2-f]quinazoline-1,3-diaMine, N3-cyclopropyl-7-[[4-(1-Methylethyl)phenyl]Methyl]-, (Hydrochloride) (1:2)infarct,SCH79797 dihydrochloride,SCH-79797 dihydrochloride,SCH-79797,SCH79797,Inhibitor,inhibit,Nonpeptide,thrombin,wortmannin,SCH 79797,antiproliferative,platelets,Protease Activated Receptor (PAR),pro-apoptotic,thrombosis,Thrombin receptors,PAR1,cardioprotection,Apoptosis
7H-Pyrrolo[3,2-f]quinazoline-1,3-diaMine, N3-cyclopropyl-7-[[4-(1-Methylethyl)phenyl]Methyl]-, (Hydrochloride) (1N*3*-Cyclopropyl-7-(4-isopropyl-benzyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochlorideN3-CYCLOPROPYL-7-[[4-(1-METHYLETHYL)PHENYL]METHYL]-7H-PYRROLO[3,2-F]QUINAZOLINE-1,3-DIAMINE DIHYDROCHLORIDESCH-79797 dihydrochlorideSCH 79797 dihydrochloride?C23H27Cl2N5orb1309114SCHEMBL29514998
Datenbank-Bezeichner
- CAS
1216720-69-2- PubChem CID
- 45073452
- DTXSID
DTXSID601028401
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 68,8 Ų
- H-Brücken-Donoren
- 4
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 5
- Schwere Atome
- 30
- Formalladung
- 0
- Komplexität
- 527
Physikochemische Eigenschaften
- storage temp.
- 2 · Store at 2-8°C, protect from light
- Löslichkeit
- 25 mM · Soluble to 25 mM in ethanol and to 50 mM in DMSO
- Aggregatzustand
- Powder
- Farbe
- White to yellow
Chemie und Industrie
Anwendungen
BeschreibungSCH 79797 is a non-peptide antagonist of proteinase-activated receptor 1 (PAR1). It blocks binding of the high affinity thrombin receptor-activating peptide (haTRAP) (IC50 = 70 nM) as well as platelet aggregation induced by either haTRAP or α-thrombin (IC50 = 0.3 and 3 μM, respectively). SCH 79797 has no activity against PAR2, PAR4, or other receptors involved in platelet activation. It also blocks PAR1 activation on vascular smooth muscle cells and endothelial cells.
VerwendenN3-Cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine Dihydrochloride is a selective PAR1 antagonist which was shown to limit myocardial ischemia/reperfusion injury in rat hearts.
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