| GHS-Einstufung | WarningH302: Harmful if swallowed [Warning Acute toxicity, oral]P264, P264+P265, P270, P280, P301+P317, P302+P352, P305+P351+P338, P321, P330, P332+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for < 0.1% (1 of 1887) of reports.H302 (> 99.9%): Harmful if swallowed [Warning Acute toxicity, oral] |
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| Regulatorische Informationen | Chemical: Phenol, 2-methoxy-Chemical: BeebreadCommission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)Phenol, 2-methoxy- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Phenol, 2-methoxy- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 08-09-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/9979Guaiacol: Does not have an individual approval but may be used under an appropriate group standard |
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| Brandgefahren | This chemical is combustible. (NTP, 1992) |
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| Brandpotenzial | This material is combustible when exposed to heat or flame. |
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| Gesundheitsgefahren | SYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin and eyes, muscular weakness, cardiovascular collapse and paralysis of the vasomotor centers. Ingestion produces burning in the mouth and throat, gastrointestinal distress, tremors and collapse. |
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| Gefahrenübersicht | Emergency treatment: Phenol and related agents[HSDB] May cause skin and eye irritationCan be absorbed through skin[CAMEO] Causes somnolence and acts as a general anestheticCauses elevation of transaminase enzymesMild eye irritant in rabbits[RTECS] Safe when used as a flavoring agent in food[JECFA] An irritant[MSDSonline] See Phenol. |
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| Reaktive Gruppe | Ethers |
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| Reactivity Profile | O-METHOXYPHENOL may react with oxidizing materials. It forms salts readily with bases. (NTP, 1992) |
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| Air and Water Reactions | Sensitive to air and light (darkens). Slightly water soluble. |
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| Toxic Combustion Products | Emits toxic fumes under fire conditions. |
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| Hazard Classes and Categories | Acute Tox. 4 (> 99.9%)Skin Irrit. 2 (100%)Acute toxicity - category 4Acute toxicity (Oral) - Category 4Acute Tox. 4 * |
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| Skin, Eye, and Respiratory Irritations | Eye, skin, gastrointestinal, and/or respiratory tract irritation ... . |
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| Brandbekämpfung | Fires involving this material should be controlled using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992) |
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| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
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| Firefighting Hazards | This material is combustible when exposed to heat or flame. If in the solid form, it is advisable to ground mechanical equipment in contact with dry material to dissipate the potential buildup of static electricity. |
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| Brandbekämpfungsverfahren | As with all fires, evacuate personnel to a safe area. Firefighters should use self-contained breathing equipment and protective clothing.Water spray, dry chemical, carbon dioxide or foam as appropriate for surrounding fire and materials. |
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| Lagerbedingungen | Store in tight, light-resistant container as defined in the USP-NF. This material should be handled and stored per label instructions to ensure product integrity. |
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| Reinigungsverfahren | Wear approved respiratory protection, chemically compatible gloves and protective clothing. Wipe up spillage or collect spillage using a high efficiency vacuum cleaner. Avoid breathing vapor or dust. Ventilate area and wash spill site. Place spillage in appropriately labelled container for disposal. |
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| Freisetung ohne Brand | SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. |
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| Entsorgungsverfahren | SRP: At the time of review, regulatory criteria for small quantity disposal are subject to significant revision, however, household quantities of waste pharmaceuticals may be managed as follows: Mix with wet cat litter or coffee grounds, double bag in plastic, discard in trash.SRP: Expired or waste pharmaceuticals shall carefully take into consideration applicable DEA, EPA, and FDA regulations. It is not appropriate to dispose by flushing the pharmaceutical down the toilet or discarding to trash. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. |
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| Preventive Measures | SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.Engineering controls such as exhaust ventilation are recommended. |
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| Personal Protective Equipment (PPE) | RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)Gloves: Chemically compatible. Eye protection: Safety goggles or glasses. Protective clothing: Protect exposed skin.Use a NIOSH-approved respirator, if it is determined to be necessary by an industrial hygiene survey involving air monitoring. If material is in solid form, the use of an approved dust mask is recommended. |
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| Wechselwirkungen | Methoxyphenol has been found to contribute to the carcinogenic effect of tobacco smoke in rats.Absorption was delayed when ibuprofen and guaiacol administered simultaneously. |
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| Ökotoxizitätswerte | EC50Species: Daphnia magna (Water flea, age 12 hr)Conditions: freshwater, static, 18 °CConcentration: 25900 ug/L for 48 hrEffect: intoxication, immobilization /formulation/ |
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| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), a Koc value of 40(2), indicates that o-methoxyphenol is expected to have very high mobility in soil(SRC). The pKa of o-methoxyphenol is 9.98(3), indicating that this compound will exist primarily in the undissociated form in the environment(SRC). Volatilization of o-methoxyphenol from moist soil surfaces is expected to be an environmental fate process(SRC) given a Henry's Law constant of 1.2X10-6 atm-cu m/mole(4). o-Methoxyphenol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.103 mm Hg at 25 °C(5). Utilizing the Japanese MITI test, 97% of the theoretical BOD was reached in four weeks(6), suggesting that biodegradation may be an important environmental fate process in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), a Koc value of 40(2) indicates that o-methoxyphenol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected to be an environmental fate process(3) based upon a Henry's Law constant of 1.2X10-6 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 34 and 251 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow of 1.32(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Utilizing the Japanese MITI test, 97% of the theoretical BOD was reached in four weeks(8), suggesting that biodegradation may be an important environmental fate process in water(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), o-methoxyphenol, which has a vapor pressure of 0.103 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase o-methoxyphenol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 13 hours(SRC), calculated from its estimated rate constant of 3.2X10-11 cu cm/molecule-sec at 25 °C(3). The sodium salt of o-methoxyphenol absorbs light at wavelengths of 289 nm(4) and therefore o-methoxyphenol may be susceptible to direct photolysis by sunlight(SRC). |
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| Lebensmitteluntersuchungswerte | o-Methoxyphenol has been detected in volatile components of popcorn(1), cooked meat (sukiyaki) probably originating from soy sauce(2), fried bacon(3) and roasted filberts(4).o-Methoxyphenol was detected in a red wine at concentrations of 23.1, 21.8, 17.0, 22.027.3, 28.2and 46.3 ug/L wine aged 12 months in barrels made of Quercus robur, Q. petrea, Q. pyrenaica, Q. faginea (Spanish oak wood)Q. robur, Q. petaea (French oak wood)and Q. alba (American oak wood), respectively. The concentration in the wine prior to aging as 15.5 ug/L. At 21 months, o-methoxyphenol concentrations were 23.2. 23.9, 20.2, 22.427.6, 27.2and 42.5 ug/L in barrels made of Q. robur, Q. petrea, Q. pyrenaica, Q. faginea (Spanish oak wood)and Q. alba (American oak wood), respectively(1). |
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| Unerwünschte Wirkungen | Neurotoxin - Acute solvent syndrome |
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| Effluent Concentrations | The concentration range of o-methoxyphenol in the effluent of a paper mill in Ontario, Canada in 1981 was 174-252 ug/L(1). It was detected in a paper mill effluent at Springfield, OR(2) and two other paper mill effluents in the U.S. in the concentration range 170-3,700 ug/L(6). The concentration of o-methoxyphenol in the combined effluent from a straw mill bleaching facility in Copenhagen, Denmark was 9,200 ug/L(3). The compound was also detected in the efflents from the following industries: timber products, leather tanning, pulp and paper, organic and plastic, and rum(4). The concentrations of o-methoxyphenol in a coal gasification condensate were 165-450 mg/L(5).In surface water adjacent to "Valley of the Drums" site in Louisville, KY, the concentration range of o-methoxyphenol was 1-25 ug/L(2). o-Methoxyphenol was detected at a concentration 0.11 ug/L in the secondary effluent at Fort Polk, LA wastewater treatment facility(3) and in the effluent of a advanced wastewater treatment plant at Pomona, CA(1). |
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| Soil Adsorption/Mobility | A log Koc of 1.60 for o-methoxyphenol, corresponding to a Koc of 40(SRC), was experimentally determined in a Brookston clay loam soil(1). A log Koc of 1.56(2), corresponding to a Koc of 36(SRC) has also been reported. According to a classification scheme(3), these Koc values suggest that o-methoxyphenol is expected to have very high mobility in soil. The pKa of o-methoxyphenol is 9.98(4), indicating that this compound will exist primarily in the undissociated form in the environment(SRC). The adsorption of the phenol occurrs by hydrogen bonding to sites on soil surfacesortho-substitution generally results in decreased adsorption compared to para-substitution due to steric hindrance(1). |
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| Natural Pollution Sources | DISCOVERED IN DISTILLATION PRODUCT FROM GUAIAC RESIN ... FOUND IN CASTOREUM OIL, IN ESSENTIAL OIL FROM FLOWERS OF PANDANUS ODORATISSIMUS L, IN DISTILLATION WATERS OF ORANGE LEAVES, IN ESSENTIAL OIL FROM CELERY SEEDS, & IN OIL FROM TOBACCO LEAVES.o-Methoxyphenol is a component of the natural food antioxidant, gum guaiac, a resinous secretion of a tropical evergreen Guaiacum officinalus(1).o-Methoxyphenol occurs naturally in animal manure and in essential oil of plants(1). |
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| Atmospheric Concentrations | URBAN/SUBURBAN: The gas phase concentration range and average concentration of o-methoxyphenol during seven rain events in Portland, OR in 1984 were 89-290 and 150 ng/cu m, respectively(1). |
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| Human Toxicity Excerpts | /OTHER TOXICITY INFORMATION/ Guaiacol, which is a phenolic compound with a methoxy group and used in traditional dental pulp sedation, has the property of inducing cell proliferation. To clarify these mechanisms of guaiacol, this study examined the hydroxyl radical (*OH) scavenging effects of guaiacol in vitro. Generation of *OH was carried out by the Fenton reaction using mixture of ascorbic acid, H2O2, and Fe(III)-EDTA, and *OH was detected by measuring the *OH-mediated production of degradation products of deoxyribose, which reacts with 2-thiobarbituric acid (TBA) and is relatively stable for a long time. At concentrations of 10(-10) M to 10(-3) M, guaiacol inhibited the TBA reactive substance (TBA-RS) formation in a dose-dependent manner. Phenol and formaldehyde were also found to inhibit the TBA-RS formation, but their inhibitory activities were lower than that of guaiacol. The concentrations of guaiacol, phenol, and formaldehyde needed to cause 50% inhibition of TBA-RS formation were approximately 5 x 10(-6), 5 x 10(-5), and 2 x 10(-3) M, respectively. In this reaction system, guaiacol showed no chelating reaction with ferrous ion and did not directly react with H2O2. Guaiacol also exhibited radical scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) stable free radical, but its scavenging activity was lower than that toward *OH. These results suggest that guaiacol is a potent scavenger of reactive oxygen radicals and that its radical scavenging activity may be associated with its effect on cell proliferation./GENOTOXICITY/ Phenolic compounds are widely used in clinical dentistry as sedatives for the dental pulp, as disinfectants for caries, and as root canal medications. The pathobiological effects of various phenolic compounds on human dental pulp fibroblasts were investigated with Hoechst 33258 fluorescence assay and DNA precipitation assay. All phenolic compounds showed cytotoxicity in Hoechst 33258 fluorescence assay by inhibiting cellular DNA in a concentration-dependent manner. The 50% inhibition concentrations required to decrease the cellular DNA contents by guaiacol, phenol, eugenol, and thymol were 9.8, 4.5, 0.9, and 0.5 mM, respectively. However these phenolic compounds did not cause DNA single-strand breaks in cultured human pulp fibroblasts. These results indicate that phenolic compounds are cytotoxic agents but are without genotoxic effects on human pulp fibroblasts in vitro. However care should be taken to reduce the possibility of pulpal as well as periapical irritations from inadvertent extrusion of these substances in clinical usage./SIGNS AND SYMPTOMS/ Guaiacol can cause neurological, hemodynamic (shock), respiratory, metabolic (metabolic acidosis), renal (acute tubular necrosis), digestive and hematologic adverse effects. Acute pulmonary edema precedes death by multiple organ failure./SIGNS AND SYMPTOMS/ Medical experience indicates that toxic quantities /of guaiacol/ can be absorbed through skin quite readily. Material is not especially irritating to skin but prolonged contact may cause injury, particularly if skin is abraded. Severely injurious to eyes.For more Human Toxicity Excerpts (Complete) data for o-Methoxyphenol (11 total), please visit the HSDB record page. |
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| Artificial Pollution Sources | o-Methoxyphenol's production and use as an expectorant(1) and food flavoring component(2) may result in its release to the environment through various waste streams(SRC). |
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| Environmental Biodegradation | AEROBIC: o-Methoxyphenol, present at 100 mg/L, reached 97% of its theoretical BOD in four weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1).AEROBIC: In a 5-day BOD test with sewage as microbial inoculum, the oxygen consumption of o-methoxyphenol was 68% of the theoretical value(1). The first order rate constants (at a constant microorganism concn) for biodegradation of o-methoxyphenol in non-adapted, phenol-adapted and cresol-adapted activated sludge were 3.64X10-4, 2.28X10-4 and 3.24X10-2 per hr, respectively(2). The first order biodegradation rate of o-methoxyphenol by non-acclimated activated sludge was 3.63X10-3/hr(6). o-Methoxyphenol completely biodegraded in 7, 0.5, and 1 hrs with an activated sludge acclimated to aniline, phenol, and m-cresol, respectivelysuspended solids concentration ranged from 4000-6000 mg/L, pH 6.1-8.3, mineral salts medium of 500 mg/L, test chemical concentration of 54 mg/L(5). A complete loss of UV absorption of o-methoxyphenol at a concentration 15 mg/L occurred in 4 days when incubated with a Niagara silt loam soil inoculum(4). The mean concentration of o-methoxyphenol in the top soil of sludge-applied field plots was 30 ug/kg on day 5. However, o-methoxyphenol was not detected in subsurface soil on day 5 and in soils of all depths on day 122 and beyond(3).ANAEROBIC: o-Methoxyphenol completely disappeared in 2 weeks when incubated with 10% sludge under anaerobic conditions(1). Greater than 75% methane production was observed in 4 weeks when o-methoxyphenol was incubated with 10% primary digester sludge under anaerobic conditions(2). Acclimated mixed methanogenic cultures mineralized o-methoxyphenol in sulfite evaporator condensate of a paper mill waste into methane gas at a concentration 560 mg/L, but was toxic to the cultures at higher concns(3). |
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| Alarmwort | Warnung |
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| Gefahrenhinweise | Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H302 |
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