Oxazolam

oxazolam · Nebusn · Toccata · Serenal · Tranquit · Hializan · Oxazolazepam · Serenal (Japanese)

Identifikatoren & physikalische Daten

CAS No.	24143-17-7
Summenformel	C18H17ClN2O2
Durchschnittliche Molmasse	328,8 g/mol
Monoisotopische Masse	328,0978555 g/mol
SMILES	CC1CN2CC(=O)Nc3ccc(Cl)cc3C2(c2ccccc2)O1
InChIKey	VCCZBYPHZRWKFY-UHFFFAOYSA-N
PubChem CID	4617
ChEMBL	CHEMBL2104805
ChEBI	CHEBI:31944
EC No.	246-032-0
DTXSID	DTXSID5023401
Lokaler Name	Oxazolam

Chemische & physikalische Eigenschaften

XLogP	3
Polarare Oberfläche (TPSA)	41,6
H-Brücken-Donoren	1
H-Brücken-Akzeptoren	3
Frei drehbare Bindungen	1
Schwere Atome	23
Formalladung	0
Komplexität	468
Kovats Retention Index	25642569258625962590
Schmelzpunkt	187°C
Siedepunkt	495.8±45.0 °C(Predicted)
Dichte	1.2065 (rough estimate)
Brechungsindex	1.5400 (estimate)
Flammpunkt	11 °C
Lagerbedingungen	2-8°C
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
pKa (Säurekonstante)	12.85±0.60(Predicted)
Aggregatzustand	A solid

Sicherheit & Vorschriften

GHS-Einstufung	DangerH301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H331 (100%): Toxic if inhaled [Danger Acute toxicity, inhalation]P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 39 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
Regulatorische Informationen	DEA schedule IV controlled substance
Hazard Classes and Categories	Acute Tox. 3 (100%)Skin Irrit. 2 (100%)Eye Irrit. 2 (100%)
Treatment	General supportive measures should be employed, along with intravenous fluids, and an adequate airway maintained. Hypotension may be combated by the use of norepinephrine or metaraminol. Dialysis is of limited value. Flumazenil (Anexate) is a competitive benzodiazepine receptor antagonist that can be used as an antidote for benzodiazepine overdose. In particular, flumazenil is very effective at reversing the CNS depression associated with benzodiazepines but is less effective at reversing respiratory depression. Its use, however, is controversial as it has numerous contraindications. It is contraindicated in patients who are on long-term benzodiazepines, those who have ingested a substance that lowers the seizure threshold, or in patients who have tachycardia or a history of seizures. As a general rule, medical observation and supportive care are the mainstay of treatment of benzodiazepine overdose. Although benzodiazepines are absorbed by activated charcoal, gastric decontamination with activated charcoal is not beneficial in pure benzodiazepine overdose as the risk of adverse effects often outweigh any potential benefit from the procedure. It is recommended only if benzodiazepines have been taken in combination with other drugs that may benefit from decontamination. Gastric lavage (stomach pumping) or whole bowel irrigation are also not recommended.
Toxizitätsübersicht	Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.
Carcinogen Classification	No indication of carcinogenicity to humans (not listed by IARC).
R-Sätze (R)	11-23/24/25-39/23/24/25-36/38-23/25
Toxizität	LD50 orl-mus: 5200 mg/kg NYKZAU 66,107,70
Gefahrensymbole	F,T
Sicherheitshinweise (S)	16-36/37-45-24
DEA Controlled Substances	CSCN: 2839CSA SCH: Schedule IVNARC: No

Anwendungen & Verwendung

Verwenden

A psychotropic agent with anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a precursor to the active substance Desmethyldiazepam (D291595).