Oxiracetam
4-hydroxy-2-oxo-1-pyrrolidineacetamid · 2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide · ct-848 · isf2522 · Neurome · Olaxitam · Olacetam · Neuractiv
Identifikatoren & physikalische Daten
| CAS No. | 62613-82-5 |
|---|---|
| Summenformel | C6H10N2O3 |
| Durchschnittliche Molmasse | 158,16 g/mol |
| Monoisotopische Masse | 158,06914218 g/mol |
| SMILES | NC(=O)CN1CC(O)CC1=O |
| InChIKey | IHLAQQPQKRMGSS-UHFFFAOYSA-N |
| PubChem CID | 4626 |
| ChEMBL | CHEMBL36633 |
| ChEBI | CHEBI:134788 |
| EC No. | 636-370-0 |
| DTXSID | DTXSID9045180 |
Chemische & physikalische Eigenschaften
| XLogP | -2,2 |
|---|---|
| Polarare Oberfläche (TPSA) | 83,6 |
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 3 |
| Frei drehbare Bindungen | 2 |
| Schwere Atome | 11 |
| Formalladung | 0 |
| Komplexität | 192 |
| Arzneimittel | DEA NFLIS-Drug Category -> Stimulants |
| Schmelzpunkt | 165-168 °C |
| Siedepunkt | 494.6±40.0 °C(Predicted) |
| Dichte | 1.416 |
| Lagerbedingungen | Sealed in dry,Room Temperature |
| Löslichkeit | DMSO (Slightly, Heated), Methanol (Slightly, Heated) |
| Aggregatzustand | Solid |
| pKa (Säurekonstante) | 13.76±0.20(Predicted) |
| Farbe | White to Off-White |
| Merck | 14,6942 |
| InChI | InChI=1S/C6H10N2O3/c7-5(10)3-8-2-4(9)1-6(8)11/h4,9H,1-3H2,(H2,7,10) |
| InChIKey | IHLAQQPQKRMGSS-UHFFFAOYSA-N |
| SMILES | N1(CC(N)=O)CC(O)CC1=O |
| CAS Datenbank | 62613-82-5(CAS DataBase Reference) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement)Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Hazard Classes and Categories | Skin Irrit. 2 (100%) |
| Wassergefährdungsklasse (WGK) | 3 |
| Zollcode | 2933.79.8500 |
| RTECS-Nr. | UX9656638 |
| R-Sätze (R) | 36/38 |
| Gefahrensymbole | Xi |
| Sicherheitshinweise (S) | 26-36 |
| Lagerklasse | 11 - Combustible Solids |
Anwendungen & Verwendung
Beschreibung
Oxiracetam is a structural analogue of piracetam. This compound has enhancing effects on vigilance and memory. In comparison with piracetam, oxiracetam exhibits greater improvement in memory (Itil et al., 1986) and has been used extensively for the treatment of dementia, including AD, VaD, MID (Baumel et al., 1989; Dysken et al., 1989), and mixed forms. Green et al. (1992) failed to demonstrate a difference from placebo in AD patients. In contrast, Maina et al. (1989) studied 289 patients with MID in a double-blind placebo-controlled trial and after 12 weeks of treatment found that oxiracetam reduced behavioural symptoms.
Verwenden
Oxiracetam is a 4-hydroxy analog of piracetam with psychostimulant activity, reportedly useful in relieving the symptoms of cerebral insufficiency in the elderly.