Oxybuprocaine
Grundinformationen
- CAS
99-43-4- Standard-SMILES
CCCCOc1cc(C(=O)OCCN(CC)CC)ccc1N- InChIKey
CMHHMUWAYWTMGS-UHFFFAOYSA-N- Summenformel
- C17H28N2O3
- Durchschnittliche Molmasse
- 308,4 g/mol
- Monoisotopische Masse
- 308,20999276
Überblick
Oxybuprocaine is a benzoate ester in which 4-amino-3-butoxybenzoic acid and 2-(diethylamino)ethanol have combined to form the ester bond; an ester-based local anaesthetic (ester "caine") used especially in ophthalmology and otolaryngology. It has a role as a local anaesthetic, a topical anaesthetic and a drug allergen. It is a benzoate ester, an amino-acid ester, a substituted aniline and a tertiary amino compound. It is functionally related to a 2-diethylaminoethanol.
Namen und Bezeichner
- Bevorzugter Name
- Oxybuprocaine
- IUPAC
- 2-(diethylamino)ethyl 4-amino-3-butoxybenzoate
- Englischer Name
- Oxybuprocaine
- Summenformel
- C17H28N2O3
- Molmasse
- 308.42
Namen und Synonyme
OxybuprocaineBenoxinate99-43-4Oxybucaine2-(Diethylamino)ethyl 4-amino-3-butoxybenzoateOxibuprokainOxyriprocaineConjucainDorsacainOxibuprocainaOxybuprocainumButoxyaminobenzoyldiethylaminoethanol
Weitere Namen anzeigen
BNXS-749FluressNovescineButoxyprocaineOxybuprocaine USP/EP/BP2-Diethylaminoethyl 4-amino-3-butoxybenzoate2-(Diethylamino)ethyl 4-amino-3-N-butoxybenzoate
Monofree oxybuprocaineBENZOIC ACID, 4-AMINO-3-BUTOXY-, 2-(DIETHYLAMINO)ETHYL ESTER4-Amino-3-butoxy-2-(diethylamino)ethyl ester benzoic acid4-Amino-3-n-butoxy-benzoesaeure-diaethylaminoaethylesterCHEBI:309594AXQ0JYM3034-Amino-3-butoxy-benzoic acid 2-diethylamino-ethyl esterDTXSID7048530
Datenbank-Bezeichner
- CAS
99-43-4- PubChem CID
- 4633
- DTXSID
DTXSID7048530- ChEMBL
CHEMBL1200- ChEBI
CHEBI:309594- UNII
- AXQ0JYM303
- Nikkaji
- J4.969G
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 3,1
- Polarare Oberfläche (TPSA)
- 64,8 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 5
- Frei drehbare Bindungen
- 11
- Schwere Atome
- 22
- Formalladung
- 0
- Komplexität
- 308
Experimentelle und physikochemische Eigenschaften
Drugs
Pharmaceuticals
Pharmaceuticals -> Listed in ZINC15
LogP3.1
Solubility
Very soluble (hydrochloride salt)
5.44e-01 g/L
42.7 [ug/mL] (The mean of the results at pH 7.4)
Human DrugsPharmaceuticals
Melting Point216.5 °C
Physical DescriptionSolid
Physikochemische Eigenschaften
- Siedepunkt
- 2 · bp2 215-218°
- Dichte
- 1.052 · 1.052±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Löslichkeit
- Methanol (Slightly)
- pka
- 9.16 · 9.16±0.25(Predicted)
- Aggregatzustand
- Oil
- Farbe
- Clear Pale Yellow
- NIST chemische Informationen
- Benoxinate(99-43-4)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- Alarmwort
- Warnung
- Gefahrenhinweise
- Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H302
Chemie und Industrie
Pharmakologische Informationen
ATC Code
S01HA02
S - Sensory organs
D - Dermatologicals
QS - Sensory organs
QD - Dermatologicals
PharmacodynamicsOxybuprocaine is a local anaesthetic. It may be less irritating than tetracaine, and the onset and duration of action are similar to tetracaine.
Mechanism of Action
Oxybuprocaine binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.
MeSH Pharmacological Classification
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
Cellular LocationsCytoplasm
Metabolite PathwaysOxybuprocaine Action Pathway
Verwendung und Herstellung
UsesUse (kg; approx.) in Germany (2009): >10
Use ClassificationPharmaceuticals
Anwendungen
VerwendenAnesthetic (topical).
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Anbieter23 Anbieter
杭州品高化工有限公司0571-87658025 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
北京索莱宝科技有限公司010-50973130 17801761073 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
上海皓鸿生物医药科技有限公司400-8210725 4008210725 · [email protected]
广州爱纯医药科技有限公司020-39119399 18927568969 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
厦门志信化学有限公司+86-5922680277 +86-13806087780 · [email protected]
艾吉析科技（上海）有限公司17717235263 17717235263 · [email protected]
上海阿拉丁生化科技股份有限公司6206333 13167063860 · [email protected]
浙江海强化工有限公司0571-86050367 0571-86960370 0571-86050387 · [email protected]
Nantong Guangyuan Chemicl Co,Ltd+86-17331189928 · [email protected]
广州阿斯利康医药有限公司17074820606 · [email protected]
Shaanxi Didu New Materials Co. Ltd+86-86-17392712779 +86-13289823923 · [email protected]
江苏艾康生物医药研发有限公司025-58851090 13913916777 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
上海迈瑞尔生化科技有限公司18621169109 · [email protected]
重庆卡兰医药有限公司[email protected]
HANGZHOU LEAP CHEM CO., LTD.+86-571-87711850 +8619957148339 · [email protected]
Wuhan Han Sheng New Material Technology Co.，Ltd+86-17798174412 · [email protected]
AFINE CHEMICALS LIMITED+86-571-85134551 +86-18958018566 · [email protected]
广州市一方医药有限公司13545625683 · [email protected]
南京世洲生物科技有限公司025-85563444 15850508050 · [email protected]
Ergänzende Hinweise
DefinitionChEBI: A benzoate ester in which 4-amino-3-butoxybenzoic acid and 2-(diethylamino)ethanol have combined to form the ester bond; an ester-based local anaesthetic (ester "caine") used especially in ophthalmology and otolaryngology.
Zugehörige Reaktionen
0
Keine Reaktionsaufzeichnungen unter den aktuellen Filterkriterien.
Notizen zur Verbindung
Wird geladen…