Grundinformationen
- CAS
125-53-1- Standard-SMILES
CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1- InChIKey
DUDKAZCAISNGQN-UHFFFAOYSA-N- Summenformel
- C20H28N2O3
- Durchschnittliche Molmasse
- 344,4 g/mol
- Monoisotopische Masse
- 344,20999276
Überblick
Oxyphencyclimine is a monocarboxylic acid.
Namen und Bezeichner
- Bevorzugter Name
- Oxyphencyclimine
- IUPAC
- (1-methyl-5,6-dihydro-4H-pyrimidin-2-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate
- Lokaler Name
- Oxyphencyclimin
- Englischer Name
- oxyphencyclimine
- Summenformel
- C20H28N2O3
- Molmasse
- 344.45
Namen und Synonyme
oxyphencyclimine125-53-1Oxyphencycliminumoxifenciclimina4V44H1O8XI(1-methyl-1,4,5,6-tetrahydropyrimidin-2-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetateDTXSID4023410RefChem:169068DTXCID403410A03AA01Benzeneacetic acid, alpha-cyclohexyl-alpha-hydroxy-, (1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl ester204-743-3
Weitere Namen anzeigen
ManirC07851ZamanilNaridan1,4,5,6-Tetrahydro-1-methyl-2-pyrimidinemethanol alpha-phenylcyclohexaneglycolate (ester)Benzeneacetic acid, α-cyclohexyl-α-hydroxy-, (1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl ester
AntulcusOxiphencycliminumOxyphencycliminum [INN-Latin]Oxifencicliminum [INN-Spanish](1-methyl-5,6-dihydro-4H-pyrimidin-2-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetateOxyphencyclimine (INN)Benzeneacetic acid, .alpha.-cyclohexyl-.alpha.-hydroxy-, (1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl esterCaridan
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 2,9
- Polarare Oberfläche (TPSA)
- 62,1 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 6
- Schwere Atome
- 25
- Formalladung
- 0
- Komplexität
- 481
Experimentelle und physikochemische Eigenschaften
LogP3.7
Solubility5.67e-02 g/L
Human DrugsPharmaceuticals
Physical DescriptionSolid
Collision Cross Section180.99 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Gefahrenhinweise
Other Safety InformationIMAP assessments - Benzeneacetic acid, .alpha.-cyclohexyl-.alpha.-hydroxy-, (1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl ester: Environment tier I assessment
Chemie und Industrie
Pharmakologische Informationen
ATC Code
A - Alimentary tract and metabolism
QA - Alimentary tract and metabolism
Pharmacodynamics
Oxyphencyclimine is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Oxyphencyclimine is an antimuscarinic, anticholinergic drug.
Mechanism of Action
Oxyphencyclimine binds the muscarinic acetylcholine receptor. It may block all three types of muscarinic receptors including M-1 receptors in the CNS and ganglia, M-2 receptors in the heart (vagus) and M-3 receptors at the parasympathetic NEJ system. The muscarinic acetylcholine receptors mediate various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Oxphencyclimine inhibits vagally mediated reflexes by antagonizing the action of acetylcholine. This in turn reduces the secretion of gastric acids in the stomach.
Cellular LocationsMembrane
Verwendung und Herstellung
Use ClassificationPharmaceuticals
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Anbieter9 Anbieter
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