Onalespib Lactate
Grundinformationen
- CAS
1019889-35-0- Standard-SMILES
CC(C)c1cc(C(=O)N2Cc3ccc(CN4CCN(C)CC4)cc3C2)c(O)cc1O.C[C@H](O)C(=O)O- InChIKey
VYRWEWHOAMGLLW-WNQIDUERSA-N- Summenformel
- C27H37N3O6
- Durchschnittliche Molmasse
- 499,6 g/mol
Überblick
Onalespib Lactate is the lactate form of onalespib, a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Onalespib selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stability and degradation of many oncogenic signaling proteins.
Namen und Bezeichner
- Bevorzugter Name
- Onalespib Lactate
- IUPAC
- (2,4-dihydroxy-5-propan-2-ylphenyl)-[5-[(4-methylpiperazin-1-yl)methyl]-1,3-dihydroisoindol-2-yl]methanone;(2S)-2-hydroxypropanoic acid
- Englischer Name
- Givinostat Hydrochloride
- Summenformel
- C27H37N3O6
- Molmasse
- 499.61
Namen und Synonyme
Onalespib lactateAT-13387 lactateOnalespib lactate [USAN]ATI-13387AUATI-13387AOnalespib l-lactateUNII-66226JUH2I66226JUH2IATI13387AUATI13387AOnalespib lactate (USAN)ONALESPIB LACTATE [WHO-DD]
Weitere Namen anzeigen
Onalespib Lactate 1019889-35-0
RefChem:168238Propanoic Acid, 2-Hydroxy-, (2S)-, Compound with (1,3-Dihydro-5-((4-methyl-1-piperazinyl)methyl)-2H-isoindol-2-yl)(2,4-dihydroxy-5-(1-methylethyl)phenyl)methanone (1:1)1019889-35-0Onalespib (lactate)orb1699774CHEMBL3301599SCHEMBL30631701VYRWEWHOAMGLLW-WNQIDUERSA-N
Datenbank-Bezeichner
- CAS
1019889-35-0- PubChem CID
- 46915024
- ChEMBL
CHEMBL3301599- UNII
- 66226JUH2I
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 125 Ų
- H-Brücken-Donoren
- 4
- H-Brücken-Akzeptoren
- 8
- Frei drehbare Bindungen
- 5
- Schwere Atome
- 36
- Formalladung
- 0
- Komplexität
- 651
Chemie und Industrie
Anbieter5 Anbieter
InvivoChem中国13549236410 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
北京新研汇医药研发有限公司13969155946 · [email protected]
InvivoChem+1-708-310-1919 +1-13798911105 · [email protected]
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