HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Paxillin
PAXILINE · mycillin · PAXILLINE · Paxicillin · Paxilline solution · Paxilline in Methanol · fromPenicilliumpaxilli · PAXILLINE, PENICILLIUM PAXILLI
Identifikatoren & physikalische Daten
| CAS No. | 57186-25-1 |
|---|---|
| Summenformel | C27H33NO4 |
| Durchschnittliche Molmasse | 435,6 g/mol |
| Monoisotopische Masse | 435,24095853 g/mol |
| SMILES | CC(C)(O)C1OC2CCC3(C)C(O)(CCC4Cc5c([nH]c6ccccc56)C43C)C2=CC1=O |
| InChIKey | ACNHBCIZLNNLRS-UHFFFAOYSA-N |
| PubChem CID | 4697 |
Chemische & physikalische Eigenschaften
| XLogP | 3,5 |
|---|---|
| Polarare Oberfläche (TPSA) | 82,6 |
| H-Brücken-Donoren | 3 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 1 |
| Schwere Atome | 32 |
| Formalladung | 0 |
| Komplexität | 868 |
| Flammpunkt | 2℃ |
| Lagerbedingungen | 2-8°C |
| Löslichkeit | Soluble in DMSO, acetone or chloroform. |
| Aggregatzustand | powder |
| Farbe | faint yellow |
| Hauptanwendungen | cleaning productscosmeticsfood and beveragespersonal care |
| InChIKey | ACNHBCIZLNNLRS-UBGQALKQSA-N |
| SMILES | N1C2=C(C=CC=C2)C2C[C@@]3([H])[C@](C)(C1=2)[C@@]1(C)CC[C@]2([H])O[C@H](C(O)(C)C)C(=O)C=C2[C@]1(O)CC3 |
Sicherheit & Vorschriften
| Treatment | To control severe tremors caused by tremorgenic mycotoxins, methocarbamol should be administered. Generalized seizures may be treated with diazepam followed by methocarbamol or a barbiturate such as pentobarbital sodium. Gastric lavage should be performed and activated charcoal administered to limit further absorption of toxins. (A744) |
|---|---|
| Gesundheitliche Auswirkungen | Tremorgenic mycotoxins affect central nervous system activity. They cause a neurological disease of cattle known as "staggers syndrome". (A2976) |
| Expositionspfade | Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) |
| Toxizitätsübersicht | Tremorgenic mycotoxins exert their toxic effects by interfering with neurotransmitter release, possibly by causing degeneration of nerve terminals. They are thought to inhibit gamma-aminobutyric acid (GABA) receptors, both pre- and postsynaptic, as well as inhibit transmitter breakdown at the GABA-T receptors. This would initially increase neurotransmitter levels, potentiating the GABA-induced chloride current, then lead to decreased levels of neurotransmitter in the synapse. In addition, paxilline inhibits presynaptic high-conductance Ca+2 activated maxi-K+ channels in the smooth muscle. Paxilline is also genotoxic and causes DNA damage. (A2976, A2993, A3026) |
| Signs and Symptoms | Tremorgenic mycotoxins affect central nervous system activity, inducing neurologic symptoms including mental confusion, paralysis, tremors, seizures, and death. They cause a neurological disease of cattle known as "staggers syndrome", which is characterized by muscle tremors, hyperexcitability, convulsions and ataxia. (A2976) |
| Carcinogen Classification | No indication of carcinogenicity to humans (not listed by IARC). |
| Wassergefährdungsklasse (WGK) | 3 |
| UN-Transportnummer | UN 2811 6.1/PG 3 |
| Zollcode | 29419090 |
| RTECS-Nr. | DJ2830000 |
| R-Sätze (R) | 23/24/25-36/37/38-41-36-20/21/22-11 |
| Gefahrensymbole | T,Xn,F |
Anwendungen & Verwendung
Beschreibung
A complex alkaloid, paxilline occurs in the mycelium of the mold Penicillium paxilli. The structure has been confirmed by X-ray crystallography. The crystals are orthorhombic with space group P2 12 121 and a = 31.009, b = 11.522 and c = 7.70 A.
Verwenden
Paxilline is a tremorgenic mycotoxin isolated from species of Penicillium, Acremonium and Emericella. Paxilline selectively blocks high-conductance Ca2+-activated potassium channels and inhibits binding to the cerebellar inositol 1,4,5-triphosphate (InsP(3)) receptor.