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5-Ethyl-5-phenyl-barbitursäure
Phenobarbitone · Fenobarbital · PHENOLBARBITAL · LUMINAL · PHENOBARBITAL (2-METHYLBUTYL-3,3,4,4-D5, 98%) · Phob · Lumen · Phenobarbitol
Identifikatoren & physikalische Daten
| CAS No. | 50-06-6 |
|---|---|
| Summenformel | C12H12N2O3 |
| Durchschnittliche Molmasse | 232,23 g/mol |
| Monoisotopische Masse | 232,08479224 g/mol |
| SMILES | CCC1(c2ccccc2)C(=O)NC(=O)NC1=O |
| InChIKey | DDBREPKUVSBGFI-UHFFFAOYSA-N |
| PubChem CID | 4763 |
| ChEMBL | CHEMBL40 |
| ChEBI | CHEBI:8069 |
| EC No. | 200-007-0 |
| DTXSID | DTXSID5021122 |
| Lokaler Name | 5-Ethyl-5-phenyl-barbitursäure |
Chemische & physikalische Eigenschaften
| XLogP | 1,5 |
|---|---|
| Polarare Oberfläche (TPSA) | 75,3 |
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 3 |
| Frei drehbare Bindungen | 2 |
| Schwere Atome | 17 |
| Formalladung | 0 |
| Komplexität | 339 |
| Arzneimittel | DEA NFLIS-Drug Category -> Depressants and TranquilizersDEA Schedule IV Controlled Substance -> DepressantsPharmaceuticals -> Diuretics (Barbiturates)Pharmaceuticals -> Metabolite of PrimidonePharmaceuticals -> Synthetic Cannabinoids or Psychoactive CompoundsPharmaceuticals -> Listed in ZINC15 |
| pH | Saturated soln in water has a pH of about 5 |
| SpringerMaterials Properties | 15N nuclear magnetic resonance spectrum |
| LogP (Verteilungskoeffizient) | log Kow = 1.471.32 |
| Geruch | Odorless |
| Geschmack | Slightly bitter taste |
| Color/Form | Crystals (3 different phases)Platelets from waterWhite, shining, crystalline powderWhite, glistening, small crystals or a white, crystalline powder which may show polymorphism |
| Löslichkeit | less than 0.1 mg/mL at 57 °F (NTP, 1992)1 g soluble in: about 1 L water8 mL alcohol40 mL chloroform12 mL etherabout 700 mL benzene. Solluble in alkali hydroxides and carbonates.LOW LIPID SOLUBILITYInsoluble in benzenesoluble in ethanol, ethyl etherslightly soluble in dimehtyl sulfoxideSoluble in alcohol, ether, chloroform, alkali hydroxides, alkali carbonate solutionsVery slightly soluble in water, freely soluble in ethanol (96 per cent). It forms water-soluble compounds with alkali hydroxides, carbonates and ammonia.<0.01 g/100 mL at 14 ºC |
| Flammpunkt | 345 °F (NTP, 1992)11 °C |
| Human Drugs | Breast FeedingLactationMilk, HumanAnticonvulsantsBarbituratesHypnotics and SedativesGABA ModulatorsAntiseizure medicines |
| Animal Drugs | Active Ingredients (Phenobarbital) -> FDA GreenbookPharmaceuticals -> UK Veterinary Medicines Directorate ListPharmaceuticals -> Animal Drugs -> Approved in Taiwan |
| Endocrine Disruptors | Potential endocrine disrupting compound |
| Schmelzpunkt | 174°C |
| Siedepunkt | 374.4°C (rough estimate) |
| Dichte | 1.2243 (rough estimate) |
| Brechungsindex | 1.6660 (estimate) |
| Lagerbedingungen | 2-8°C |
| Aggregatzustand | Solid |
| pKa (Säurekonstante) | 7.3, 11.8(at 25℃) |
| Farbe | White to Off-White |
| Merck | 13,7319 |
| Henry-Konstante | 5.8×108 mol/(m3Pa) at 25℃, HSDB (2015) |
| BCS Class | 1 |
| Stabilität | Stable. Combustible. Incompatible with strong oxidizing agents. |
| CAS Datenbank | 50-06-6(CAS DataBase Reference) |
| NIST chemische Informationen | Barbituric acid, 5-ethyl-5-phenyl-,(50-06-6) |
| EPA chemische Informationen | Phenobarbital (50-06-6) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH301 (99.5%): Toxic if swallowed [Danger Acute toxicity, oral]P203, P261, P264, P270, P272, P280, P301+P316, P302+P352, P318, P321, P330, P333+P317, P362+P364, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 195 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H350: May cause cancer [Danger Carcinogenicity] |
|---|---|
| Regulatorische Informationen | Hazard Traits - CarcinogenicityDEA schedule IV controlled substanceStatus: Active Update: 23-03-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/23297Phenobarbital: Does not have an individual approval but may be used under an appropriate group standard |
| Weitere Sicherheitsinformationen | IMAP assessments - 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-phenyl-: Human health tier I assessment |
| DOT-Kennzeichnung | Poison |
| Brandgefahren | This chemical is combustible. (NTP, 1992) |
| Gesundheitsgefahren | SYMPTOMS: Symptoms of exposure to this class of compounds via ingestion include sedation, nystagmus, ataxia, irritability and hyperexcitability in children, exfoliative dermatitis and hypoprothrombinemia in the neonate. Other symptoms via ingestion include confusion and restlessness in the elderly or in the presence of painrespiratory depression, occasional allergic reactions, particularly affecting the skinmaculopapular skin rash, fixed-drug eruptions purpura, photosensitivity, erythema multiforme (the Stevens-Johnson syndrome), toxic epidermal necrolysis, hypothermia with associated pyrexia during recoveryhepatitis, cholestasis, nephritis, hepatic dysfunction and shoulder-hand syndrome. Ingestion may cause agitation in the elderly, hemorrhage in the neonate, morbilliform or scarlatiniform rash, megaloblastic anemia and osteomalacia. Ingestion can also cause sleepiness, unsteadiness, mental confusion, slow and shallow respiration, flaccid muscles, hypotension, cyanosis, hyperthermia, absent reflexes and coma. The duration of coma is dependent on the dose. Cerebral edema contributes to the persistence of coma. If coma persists, moist rales are heard in the lower lung fields, indicating pulmonary edema. Atelectasis or aspiration pneumonia with signs of lung consolidation and fever can also occur. Carbon dioxide retention under these conditions can cause acidosis. Death may occur from pneumonia, pulmonary edema or refractory hypotension. Other symptoms of exposure may include drowsiness, headache, irregular respiration and central nervous system effects Inhalation of the dust may cause irritation of the upper respiratory tract. Hypnosis and excitement have been reported. Other reported symptoms include delirium and deep unconsciousness. It can cause poor judgment and hangover. Chronic symptoms include effects on neurological and pyschic functions, disorientation, skin rash, ataxia, dizziness, depression an foliate deficiency. Chronic exposure may also result in drowsiness, emotional lability, irritability, neglect of personal appearance and other behavior disturbances. Other symptoms of chronic exposure are nystagmus, tremor, mild changes in mental condition such as loss of memory, inability to concentrate, giddiness, depression and dullness of mental perception, and precipitation of acute porphyria. Overdosage may cause hemorrhagic and erythematous bullae, respiratory depression, cardiovascular depression, hypotension and shock leading to renal failureprolonged coma and death due t respiratory or circulatory failure. Absent bowel sounds are a sign of severe poisoning and their return sometimes indicates further absorption of any remaining compound in the gastrointestinal tract with resultant relapse. Dangerous central nervous system effects occur in children at 10 mg/kg. It causes respiratory depression in the neonate and diminished milk flow in the nursing mother. Eye effects through ingestion include slow eye reaction to light, mydriasis, miosis, bilateral ptosis, rapid fluttering of the eyelids, disturbance of eye movement, weakness of convergence, weakness of vertical gaze and of individual extraocular muscles and transient loss of vision following coma. There has been one case of spontaneous abortion. Exposure to this compound may also cause somnolence, motor activity changes, pulmonary changes, allergic dermatitis, fever, developmental abnormalities of the central nervous system, body wall, musculoskeletal, respiratory, gastrointestinal and urogenital systems. It may also cause jaundice. This compound may increase the metabolism of other drugs. Pyschic or physical dependence may occur with continued use. Abrupt withdrawal may result in severe abstinence syndrome which includes grand mal seizures and delirium. |
| FDA-Anforderungen | Schedule IV shall consist of the drugs and other substances, by whatever official name, common or usual name, chemical name, or brand name designated, listed in this section. Each drug or substance has been assigned the DEA Controlled Substances Code Number set forth opposite it. Depressants: Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances, including its salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation: Phenobarbital (DEA Code Number: 2285) is included on this list. |
| Reaktive Gruppe | Amides and Imides |
| Special Reports | DHHS/NIDAResearch Monograph Series 52: Testing Drugs for Physical Dependence Potential and Abuse Liability (1984) DHHS Pub No. (ADM)87-1332[Available from, as of March 29, 2010: http://www.nida.nih.gov/pdf/monographs/download52.html]Research Monograph Series 54: Mechanisms of Tolerance and Dependence (1984) DHHS Pub No. (ADM)88-1330[Available from, as of March 29, 2010: http://www.nida.nih.gov/pdf/monographs/download54.html]Research Monograph Series 56: Etiology of Drug Abuse: Implications for Prevention (1987) DHHS Pub No. (ADM)87-1335[Available from, as of March 29, 2010: http://www.nida.nih.gov/pdf/monographs/download56.html]Research Monograph Series 59: Current Research on the Consequences of Maternal Drug Abuse (1985) DHHS Pub No. (ADM)85-1400[Available from, as of March 29, 2010: http://www.nida.nih.gov/pdf/monographs/monograph59/download59.html]For more Special Reports (Complete) data for Phenobarbital (8 total), please visit the HSDB record page. |
| Reactivity Profile | PHENOBARBITAL is also sensitive to prolonged exposure to light. Incompatible with strong oxidizing agents. Forms a complex of reduced solubility with macrogol 4000. Able to form metal derivatives (NTP, 1992). |
| Air and Water Reactions | Sensitive to hydrolysis. Alkaline solutions react more rapidly than acidic solutions. At pH 7 and 176 °F, has a half life of 74 hours. Insoluble in water. |
| Hazard Classes and Categories | Acute Tox. 3 (99.5%)Acute toxicity (Oral) - Category 3Carcinogenicity - Category 1B |
| Skin, Eye, and Respiratory Irritations | May cause irritation. Remove to fresh air. Flush with copious quantities of water. |
| Brandbekämpfung | Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be use. (NTP, 1992) |
| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
| Brandbekämpfungsverfahren | Water spray, dry chemical, carbon dioxide, or foam as appropriate for surrounding fire and materials.As with all fires, evacuate personnel to a safe area. Firefighters should use self-contained breathing equipment and protective clothing. |
| Lagerbedingungen | Store in tight container as defined in the USP-NF. This material should be handled and stored per label instructions to ensure product integrity.Store below 40 °C (104 °F), preferably between 15 and 30 °C (59 and 86 °F), unless otherwise specified by manufacturer. Store in a well-closed, light-resistant container. Protect from freezing. |
| Reinigungsverfahren | Wipe up spillage or collect spillage using a high- efficiency vacuum cleaner. Avoid breathing dust. Wash spill site. Place spillage and all contaminated cleanup materials in a thick plastic hazardous waste disposal bag or leakproof container and label it CAUTION: HAZARDOUS CHEMICAL WASTE. |
| Freisetung ohne Brand | SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. |
| Entsorgungsverfahren | SRP: Expired or waste pharmaceuticals shall carefully take into consideration applicable DEA, EPA, and FDA regulations. It is not appropriate to dispose by flushing the pharmaceutical down the toilet or discarding to trash. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.SRP: At the time of review, regulatory criteria for small quantity disposal are subject to significant revision, however, household quantities of waste pharmaceuticals may be managed as follows: Mix with wet cat litter or coffee grounds, double bag in plastic, discard in trash. |
| Preventive Measures | This material is assumed to be combustible. As with all dry powders, it is advisable to ground mechanical equipment in contact with dry material to dissipate the potential buildup of static electricity.As a general rule, when handling USP Reference Standards avoid all contact and inhalation of dust, mists, and/or vapors associated with the material. Wash thoroughly after handling./Use/ safety glasses or goggles /and/ protect exposed skin. |
| Isolation and Evacuation | Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: |
| Personal Protective Equipment (PPE) | RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)Engineering controls such as exhaust ventilation are recommended.Use a NIOSH-approved respirator, if it is determined to be necessary by an industrial hygiene survey involving air monitoring. In the event that a respirator is not required, an approved dust mask should be used. |
| Treatment | Treatment of overdosage is mainly supportive and consists of maintaining an adequate airway with assisted respiration and oxygen administration as necessary, as well as monitoring of vital signs and fluid balance. If the patient is conscious and has not lost the gag reflex, emesis may be induced with ipecac. Care should be taken to prevent pulmonary aspiration of vomitus. After completion of vomiting, 30 grams activated charcoal in a glass of water may be administered. If emesis is contraindicated, gastric lavage may be performed with a cuffed endotracheal tube in place with the patient in the face down position. Activated charcoal may be left in the emptied stomach and a saline cathartic administered. Fluid therapy and other standard treatment for shock should be performed if needed. If renal function is normal, forced diuresis may aid in the elimination of the barbiturate. Alkalinization of the urine increases renal excretion of some barbiturates, especially phenobarbital, also aprobarbital, and mephobarbital (which is metabolized to phenobarbital). Although not recommended as a routine procedure, hemodialysis may be used in severe barbiturate intoxications or if the patient is anuric or in shock. Patient should be rolled from side to side every 30 minutes, and antibiotics should be given if pneumonia is suspected. Appropriate nursing care to prevent hypostatic pneumonia, decubiti, aspiration and other complications of patients with altered states of consciousness should also be performed. (L1712) |
| Wechselwirkungen | Chronic use of barbiturates prior to enflurane, halothane, or methoxyflurane anesthesia may increase anesthetic metabolism leading to increased risk of hepatotoxicity. Chronic use of barbiturates prior to methoxyflurane anesthesia may increase formation of nephrotoxic metabolites leading to increased risk of nephrotoxicity. /Barbiturates/Osteopenia induced by barbiturates, especially phenobarbital, may be enhanced when carbonic anhydrase inhibitors are used concurrentlyit is recommended that patients receiving concurrent therapy be monitored for early signs of osteopenia and that the carbonic anhydrase inhibitor be discontinued and appropriate treatment initiated if necessary. /Barbiturates/Concurrent use with barbiturates, especially phenobarbital, may reduce serum disopyramide to ineffective concentrationstherefore, monitoring of its serum concentrations is necessary during concurrent therapy. /Barbiturates/Concurrent use of divalproex sodium or valproic acid may decrease the metabolism of barbiturates, resulting in increased serum concentrations, which may lead to increased CNS depression and neurological toxicitybarbiturate serum concentrations should be monitored to determine if dosage adjustment is necessary when these medications are used concurrently. Also, the half-life of valproic acid may be decreased and dosage adjustment may be necessary. In addition, phenobarbital may enhance valproic acid hepatotoxicity, presumably through the formation of hepatotoxic valproate metabolites.For more Interactions (Complete) data for Phenobarbital (40 total), please visit the HSDB record page. |
| Gesundheitliche Auswirkungen | They cause slurred speech, disorientation and "drunken" behavior. They are physically and psychologically addictive. May cause a potentially dangerous rash that may develop into Stevens Johnson syndrome, an extremely rare but potentially fatal skin disease. |
| Hepatotoxicity | Prospective studies suggest that less than 1% of subjects develop elevations in serum aminotransferase levels during long term phenobarbital therapy. Clinically apparent hepatotoxicity from phenobarbital is rare but can be abrupt in onset, severe and even fatal. Phenobarbital hepatotoxicity typically occurs in the setting of anticonvulsant hypersensitivity syndrome with onset of fever, rash, facial edema, lymphadenopathy, elevations in white count and eosinophilia occurring 1 week to several months after starting therapy. Liver involvement is common, but is usually mild and anicteric and overshadowed by other features of hypersensitivity (rash, fever). In some cases, hepatic involvement is more prominent with marked elevations in serum enzyme levels, jaundice and even signs of hepatic failure. The typical pattern of serum enzyme elevations is mixed, but can be hepatocellular or cholestatic. Liver biopsy shows mixed hepatitis-cholestatic injury with prominence of eosinophils and occasionally granulomata. Re-exposure usually results in recurrence and should be avoided. |
| Ökotoxizitätswerte | LC50Species: Daphnia magna (Water flea)Concentration: 1,460 mg/L for 24 hr /Conditions of bioassay not specified/Species: Pimephales promelas (Fathead minnow, age 30 days, mean length 16.5 mm, mena weight 0.067 g)Conditions: flow through, 24.9 °C, pH 7.8, hardness 45.1 mg/L CaCO3, alkalinity 108 mg/L CaCO3, dissolved oxygen 6.8 mg/LConcentration: 484 mg/L for 96 hr (95% confidence limit: 446-526 mg/L) /99+% purity/ |
| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 59(SRC), determined from a log Kow of 1.47(2) and a regression-derived equation(3), indicates that phenobarbital is expected to have high mobility in soil(SRC). The pKa of phenobarbital is 7.3(4), indicating that this compound will exist partially in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Volatilization of the neutral species from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.7X10-14 atm-cu m/mole(SRC), using a fragment constant estimation method(6). Phenobarbital is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.4X10-11 mm Hg at 25 °C(SRC), determined from a fragment constant method(7). Utilizing the Japanese MITI test, 0% of the theoretical BOD was reached in 4 weeks(8) indicating that biodegradation is not an important environmental fate process(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 59(SRC), determined from a log Kow of 1.47(2) and a regression-derived equation(3), indicates that phenobarbital is not expected to adsorb to suspended solids and sediment(SRC). Volatilization of the neutral species from water surfaces is not expected(4) based upon an estimated Henry's Law constant of 1.7X10-14 atm-cu m/mole(SRC), developed using a fragment constant estimation method(5). According to a classification scheme(6), an estimated BCF of 4(SRC),from its log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Utilizing the Japanese MITI test, 0% of the theoretical BOD was reached in 4 weeks(8) indicating that biodegradation is not an important environmental fate process(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), phenobarbital, which has an estimated vapor pressure of 1.4X10-11 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase phenobarbital may be removed from the air by wet or dry deposition(SRC). Phenobarbital contains chromophores that absorb at wavelengths >290 nm(4) and therefore may be susceptible to direct photolysis by sunlight(SRC). |
| Unerwünschte Wirkungen | Complications associated with phenobarbital use include coma, impaired breathing effort, low blood pressure, incoordination, poor balance, and drowsiness. These adverse effects, stemming from phenobarbital usage, impact older patients to a greater degree. Therefore, newer antiepileptics (lamotrigine, levetiracetam) are preferred as seizure treatment in this patient population. |
| Expositionspfade | Absorbed in varying degrees following oral, rectal or parenteral administration. The salts are more rapidly absorbed than are the acids. The rate of absorption is increased if the sodium salt is ingested as a dilute solution or taken on an empty stomach. |
| Milk Concentrations | Because barbiturates are distributed into the milk of nursing women, nursing should be discontinued if nursing infants of barbiturate-treated women exhibit signs of toxicity. /Barbiturates General Statement/Phenobarbital is excreted into breast milk. In two reports, the milk:plasma ratio varied between 0.4-0.6. The amount of phenobarbital ingested by the nursing infant has been estimated to reach 2-4 mg/day. ... Due to slower elimination in the nursing infant, accumulation may occur to the point that blood levels in the infant may actually exceed those of the mother. Phenobarbital-induced sedation has been observed in three nursing infants probably caused by this accumulation.The drugs are distributed into milk in concentrations much lower than those in plasma. /Barbiturates General Statement/A case of withdrawal in a 7 month old nursing infant after abrupt weaning from a mother taking phenobarbital, primidone, and carbamazepine has been reported. The mother had taken the anticonvulsant agents throughout gestation and during lactation. The baby's serum phenobarbital level at approximately 8 weeks of age was 13.8 umol/L, near the lower level of the therapeutic range. At 7 months of age, the mother abruptly stopped nursing her infant and, shortly thereafter, withdrawal symptoms were observed in the infant consisting of episodes of "startle" responses, and infantile spasms confirmed by EEG. The infant was treated with phenobarbital with prompt resolution of her symptoms and she was gradually weaned from the drug over a 6 month interval. Her neurological and mental development were normal during the subsequent 5 year follow-up period.Phenobarbital is excreted into breast milk. In two reports, the milk:plasma ratio varied between 0.4-0.6. The amount of phenobarbital ingested by the nursing infant has been estimated to reach 2-4 mg/day. The pharmacokinetics of phenobarbital during lactation have been reviewed. Due to slower elimination in the nursing infant, accumulation may occur to the point that blood levels in the infant may actually exceed those of the mother. Phenobarbital induced sedation has been observed in three nursing infants probably caused by this accumulation. |
| Toxizitätsübersicht | Barbiturate toxicity is noticeable at 1 g orally, although this varies depending on the individual. Doses above 2 g can result in death, but the deadly dose usually is between 40 and 80 μg/mL.Phenobarbital acts on GABAA receptors, increasing synaptic inhibition. This has the effect of elevating seizure threshold and reducing the spread of seizure activity from a seizure focus. Phenobarbital may also inhibit calcium channels, resulting in a decrease in excitatory transmitter release. The sedative-hypnotic effects of phenobarbital are likely the result of its effect on the polysynaptic midbrain reticular formation, which controls CNS arousal. |
| Ökotoxizitätsauszüge | /BIRDS and MAMMALS/ Livers from mallards (Anas platyrhynchos) were treated with either beta-naphthoflavone (50 mg/kg) or phenobarbital (70 mg/kg). Purification of induced hepatic cytochrome P450 was accomplished using both DEAE and hydroxyapatite columns, as well as sodium dodecyl sulfate polyacrylamide gel electrophoresis separation. Polyclonal antibodies to these proteins were then produced in young male New Zealand White rabbits. beta-Naphthoflavone (betaNF) - and phenobarbital (PB) -treated red-winged blackbird, screech owl, European starling, and lesser scaup liver microsomes were analyzed in western blots for species cross-reactivity.Although all four of these avain species exhibited cross-reactivity with antibodies to betaNF-induced mallard P450, all but the lesser scaup revealed a protein of higher molecular weight than that of the betaNF-induced mallard. In addition, only the lesser scaup exhibited cross-reactivity with the anti-PB-induced mallard P450 antibodies. |
| Signs and Symptoms | CNS and respiratory depression which may progress to Cheyne-Stokes respiration, areflexia, constriction of the pupils to a slight degree (though in severe poisoning they may wshow paralytic dilation), oliguria, tachycardia, hypotension, lowered body temperature, and coma. Typical shock syndrome (apnea, circulatory collapse, respiratory arrest, and death) may occur. |
| Wassergefährdungsklasse (WGK) | 3 |
| UN-Transportnummer | UN 2811 6.1/PG 3 |
| Zollcode | 2933530000 |
| RTECS-Nr. | CQ6825000 |
| R-Sätze (R) | 61-25-40-43-39/23/24/25-23/24/25-11 |
| Toxizität | LD50 orally in rats: 162 ±14 mg/kg (Goldenthal) |
| Gefahrensymbole | T,F |
| Sicherheitshinweise (S) | 53-36/37-45-16 |
| Gefahrenklasse | 6.1(b) |
| Verpackungsgruppe | III |
| Gefahrstoffdaten | 50-06-6(Hazardous Substances Data) |
Anwendungen & Verwendung
Beschreibung
Phenobarbital (Item No. 9001494) is an analytical reference material categorized as a barbiturate. Phenobarbital is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications.
Verwenden
Phenobarbital exhibits relaxant, soporific, and anticonvulsant activities. It is widely used in treating epilepsy, chorea, and spastic paralysis, and is used as a component of a large number of combined drugs, valocordin and corvalol in particular.