Grundinformationen
- Standard-SMILES
Cc1cccc(C)c1NC(=O)CC12CCCN1CCC2- InChIKey
BCQTVJKBTWGHCX-UHFFFAOYSA-N- Summenformel
- C17H24N2O
- Durchschnittliche Molmasse
- 272,4 g/mol
- Monoisotopische Masse
- 272,18886339
Überblick
Pilsicainide is a secondary carboxamide resulting from the formal condensation of the amino group of 2,6-dimethylaniline with the carboxy group of (tetrahydro-1H-pyrrolizin-7a(5H)-yl)acetic acid. It is a sodium channel blocker which is used as an antiarrhythmic drug for the management of atrial tachyarrhythmias in Japan. It has a role as an anti-arrhythmia drug and a sodium channel blocker. It is a secondary carboxamide and an organic heterobicyclic compound.
Namen und Bezeichner
- Bevorzugter Name
- Pilsicainide
- IUPAC
- N-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamide
- Englischer Name
- PILSICAINIDE
- Summenformel
- C17H24N2O
- Molmasse
- 272.39
Namen und Synonyme
Weitere Namen anzeigen
Datenbank-Bezeichner
- CAS
88069-67-4- PubChem CID
- 4820
- DTXSID
DTXSID1046639- ChEMBL
CHEMBL163238- ChEBI
CHEBI:135127- UNII
- AV0X7V6CSE
- Nikkaji
- J355.412K
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 2,7
- Polarare Oberfläche (TPSA)
- 32,3 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 3
- Schwere Atome
- 20
- Formalladung
- 0
- Komplexität
- 348
Experimentelle und physikochemische Eigenschaften
Physikochemische Eigenschaften
- storage temp.
- 2 · Sealed in dry,2-8°C
Sicherheit und Regulatorisches
Toxikologische Informationen
Drug Induced Liver Injury
Drug-Induced Liver Injury Severity and Toxicity (DILIst)
Pilsicainide
DILI Positive
DOI:10.1016/j.drudis.2019.09.022
Sicherheitsdaten
- risk_code
- 22
- hazard_code
- Xn
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity.
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