Pimobendan

HCID 4823CAS 118428-37-8
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Grundinformationen

Standard-SMILES
COc1ccc(-c2nc3ccc(C4=NNC(=O)CC4C)cc3[nH]2)cc1
InChIKey
GLBJJMFZWDBELO-UHFFFAOYSA-N
Summenformel
C19H18N4O2
Durchschnittliche Molmasse
334,4 g/mol
Monoisotopische Masse
334,14297582

Überblick

Pimobendan is a member of benzimidazoles and a pyridazinone. It has a role as a vasodilator agent, a cardiotonic drug and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor.

Namen und Bezeichner

Bevorzugter Name
Pimobendan
IUPAC
3-[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one
Englischer Name
l-Pimobendan
Summenformel
C19H18N4O2
Molmasse
334.37

Namen und Synonyme

pimobendan74150-27-9pimobendaneAcardidl-PimobendanVetmedinPimobendanumRacemic pimobendanUD-CG-115BSUD-CG-115UDCG-115Pimobendan,USP
Weitere Namen anzeigen
i-Pimobendanl-Pimobendan
Vetmedin Solution34AP3BBP9TDTXSID8048280FORTEKOR PLUS COMPONENT PIMOBENDANCHEBI:320033(2H)-Pyridazinone, 4,5-dihydro-6-(2-(4-methoxyphenyl)-1H-benzimidazol-5-yl)-5-methyl-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-4,5-dihydropyridazin-3(2H)-oneUD-CG115

Datenbank-Bezeichner

CAS
118428-37-8、118428-38-9、74150-27-9
PubChem CID
4823
DTXSID
DTXSID8048280
ChEMBL
CHEMBL24646
ChEBI
CHEBI:32003
UNII
34AP3BBP9T、613JXV89SU、9HTU209Z0N
EC Number
640-420-7
Nikkaji
J34.390K

Eigenschaften

Berechnete Struktureigenschaften

XLogP
2,7
Polarare Oberfläche (TPSA)
79,4 Ų
H-Brücken-Donoren
2
H-Brücken-Akzeptoren
4
Frei drehbare Bindungen
3
Schwere Atome
25

Experimentelle und physikochemische Eigenschaften

Animal Drugs · 2 Einträge

FDA approved animal drugs -> Active ingredient

Pharmaceuticals -> UK Veterinary Medicines Directorate List

Physikochemische Eigenschaften

Siedepunkt
471.18 °C · 471.18°C (rough estimate)
Dichte
1.2421 · 1.2421 (rough estimate)
Brechungsindex
1.662 · 1.6620 (estimate)
pka
10.21 · 10.21±0.10(Predicted)

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Danger

H301 (20%): Toxic if swallowed [Danger Acute toxicity, oral]

P203, P261, P264, P270, P271, P273, P280, P301+P316, P301+P317, P304+P340, P317, P318, P321, P330, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 10 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory InformationPimobendan: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Hazard Classes and CategoriesAcute Tox. 3 (20%)

Chemie und Industrie

Pharmakologische Informationen

ATC CodeQC - Cardiovascular system
MeSH Pharmacological Classification · 3 Einträge

Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).

Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.

Drugs used to cause dilation of the blood vessels.

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