HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Practolol
dalzic · ay21011 · eraldin · ici50172 · PRACTOLOL · practalol · Zefamenib · praktololu
Identifikatoren & physikalische Daten
| CAS No. | 6673-35-4 |
|---|---|
| Summenformel | C14H22N2O3 |
| Durchschnittliche Molmasse | 266,34 g/mol |
| Monoisotopische Masse | 266,16304257 g/mol |
| SMILES | CC(=O)Nc1ccc(OCC(O)CNC(C)C)cc1 |
| InChIKey | DURULFYMVIFBIR-UHFFFAOYSA-N |
| PubChem CID | 4883 |
| ChEMBL | CHEMBL6995 |
| ChEBI | CHEBI:258351 |
| EC No. | 229-712-1 |
| DTXSID | DTXSID0021179 |
| Lokaler Name | Practolol |
Chemische & physikalische Eigenschaften
| XLogP | 0,8 |
|---|---|
| Polarare Oberfläche (TPSA) | 70,6 |
| H-Brücken-Donoren | 3 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 7 |
| Schwere Atome | 19 |
| Formalladung | 0 |
| Komplexität | 263 |
| LogP (Verteilungskoeffizient) | 0.790.74 |
| Löslichkeit | 4.90e-01 g/LDMSO (Slightly), Methanol (Slightly) |
| Human Drugs | Pharmaceuticals |
| Schmelzpunkt | 134-136 °C134 - 136 °C134-136° (BuOAc) |
| Physical Description | Solid |
| Siedepunkt | 409.54°C (rough estimate) |
| Dichte | 1.0807 (rough estimate) |
| Brechungsindex | 1.5110 (estimate) |
| Lagerbedingungen | Refrigerator |
| Aggregatzustand | Solid |
| pKa (Säurekonstante) | pKa 9.5 (Uncertain) |
| Farbe | White to Off-White |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]P203, P260, P264, P270, P280, P301+P317, P302+P352, P318, P319, P321, P330, P332+P317, P362+P364, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Weitere Sicherheitsinformationen | IMAP assessments - Acetamide, N-[4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-: Environment tier I assessment |
| Hazard Classes and Categories | Acute Tox. 4 (50%) |
Anwendungen & Verwendung
Verwenden
N-[4-[2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPOXY]PHENYL]ACETAMIDE is a selective adrenergic β-receptor blocking drug with antihyperstensive activity. N-[4-[2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPOXY]PHENYL]ACETAMIDE has been used in the emergency treatment of cardiac arrhythmias.