Proglumetacin
Grundinformationen
- CAS
57132-53-3- Standard-SMILES
CCCN(CCC)C(=O)C(CCC(=O)OCCCN1CCN(CCOC(=O)Cc2c(C)n(C(=O)c3ccc(Cl)cc3)c3ccc(OC)cc23)CC1)NC(=O)c1ccccc1- InChIKey
PTXGHCGBYMQQIG-UHFFFAOYSA-N- Summenformel
- C46H58ClN5O8
- Durchschnittliche Molmasse
- 844,4 g/mol
- Monoisotopische Masse
- 843,3973915
Überblick
Proglumetacin is a carboxylic ester obtained by formal condensation of the carboxy group of indometacin with the hydroxy group of 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl N2-benzoyl-N,N-dipropyl-alpha-glutaminate. Used (as its dimaleate salt) to control pain and inflammation associated with musculoskeletal and joint disorders. Following oral administration, it is metabolised to indometacin and proglumide, a drug with antisecretory effects that helps prevent injury to the stomach lining. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, a lipoxygenase inhibitor and a prodrug. It is a member of benzamides, a carboxylic ester, an aromatic ether, a N-alkylpiperazine, a N-acylindole and a member of monochlorobenzenes. It is functionally related to a proglumide and an indometacin.
Namen und Bezeichner
- Bevorzugter Name
- Proglumetacin
- IUPAC
- 3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-benzamido-5-(dipropylamino)-5-oxopentanoate
- Englischer Name
- PROGLUMETACIN MALEATE
- Summenformel
- C46H58ClN5O8
- Molmasse
- 844.43
Namen und Synonyme
PROGLUMETACIN57132-53-3ProglumetacinaProglumetacineProglumetacinumDTXSID0048842FV919079LUDTXCID3028768CHEBI:76263RefChem:176175M01AB143-(4-(2-((2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetyl)oxy)ethyl)piperazin-1-yl)propyl 4-(dipropylcarbamoyl)-4-(phenylformamido)butanoate
Weitere Namen anzeigen
PROGLUMETACIN MALEATE1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester (9CI)1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester, (+-)-
3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-benzamido-5-(dipropylamino)-5-oxopentanoateProglumetacin (INN)NCGC00183024-01PROGLUMETACIN [INN]1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl esterProglumetacin [INN:BAN]Proglumetacine [INN-French]Proglumetacinum [INN-Latin]
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 7,3
- Polarare Oberfläche (TPSA)
- 140 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 10
- Frei drehbare Bindungen
- 23
- Schwere Atome
- 60
- Formalladung
- 0
- Komplexität
- 1.360
Experimentelle und physikochemische Eigenschaften
DrugsPharmaceuticals
Physikochemische Eigenschaften
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
- Aggregatzustand
- Solid
- Farbe
- White to Pale Yellow
Chemie und Industrie
Pharmakologische Informationen
ATC Code
M - Musculo-skeletal system
QM - Musculo-skeletal system
MeSH Pharmacological Classification
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Verwendung und Herstellung
UsesUse (kg; approx.) in Germany (2009): >500
Anbieter7 Anbieter
Pure Chemistry Scientific Inc.001-857-928-2050 or 1-888-588-9418 · [email protected]
深圳市祥根生物医药有限公司0755-28967200 13631290199 · [email protected]
Capot Chemical Co.,Ltd.+86-（0）57185586718 +86-13336195806 · [email protected]
深圳聚合生化科技有限公司+86-400-002-6226 13028896684 · [email protected]
Capot Chemical Co., Ltd+86 (0) 571 85 58 67 18
北京百灵威科技有限公司18210857532 18210857532 · [email protected]
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