HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Propiomazin
Wy-1359 · CB-1678 · propiomazine · (±)-Propiomazine · propiomazine USP/EP/BP · 1-[10-[2-(Dimethylamino)propyl]phenothiazin-2-yl-1-propanone · 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one · 1-[10-[2-(Dimethylamino)propyl]-10H-phenothiazin-2-yl]propan-1-one
Identifikatoren & physikalische Daten
| CAS No. | 362-29-8 |
|---|---|
| Summenformel | C20H24N2OS |
| Durchschnittliche Molmasse | 340,5 g/mol |
| Monoisotopische Masse | 340,16093457 g/mol |
| SMILES | CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2 |
| InChIKey | UVOIBTBFPOZKGP-UHFFFAOYSA-N |
| PubChem CID | 4940 |
| ChEMBL | CHEMBL1201210 |
| ChEBI | CHEBI:8491 |
| EC No. | 206-646-1 |
| DTXSID | DTXSID1023520 |
| Lokaler Name | Propiomazin |
Chemische & physikalische Eigenschaften
| XLogP | 4,8 |
|---|---|
| Polarare Oberfläche (TPSA) | 48,9 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 5 |
| Schwere Atome | 24 |
| Formalladung | 0 |
| Komplexität | 441 |
| LogP (Verteilungskoeffizient) | 4.54.4 |
| Löslichkeit | SLOWLY OXIDIZED WHEN MOISTENED OR IN AQUEOUS SOLN ON PROLONGED EXPOSURE TO AIR &/OR LIGHT1 G SOL IN 4.5 ML WATERFREELY SOL IN ALCOHOLINSOL IN BENZENE /HYDROCHLORIDE/7.03e-03 g/L |
| Human Drugs | Pharmaceuticals |
| Siedepunkt | 235-245 °C @ 0.5 MM HGbp0.5 235-245° |
| Schmelzpunkt | MP: 160-161 °CCRYSTALS FROM ISOPROPANOL /MALEATE/MP: 201-206 °C /HYDROCHLORIDE/MP: 240-242 °C /METHIODIDE/ |
| Physical Description | Solid |
| Other Experimental Properties | PRACTICALLY ODORLESSYELLOW POWDER /HYDROCHLORIDE/ |
| Dichte | 1.137±0.06 g/cm3(Predicted) |
| pKa (Säurekonstante) | pKa 6.6(H2O) (Uncertain) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P270, P272, P273, P280, P301+P317, P302+P352, P321, P330, P333+P317, P362+P364, P391, and P501 (click each P-code to see the statement)The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. |
|---|---|
| Hazard Classes and Categories | Acute Tox. 4 (100%) |
| Wechselwirkungen | ...ENHANCES EFFECT OF CNS DEPRESSANTS: HENCE, DOSE OF BARBITURATES GIVEN CONCOMITANTLY SHOULD BE REDUCED 1/2, DOSES OF MEPERIDINE & MORPHINE SHOULD BE REDUCED 1/4 TO 1/2. /HYDROCHLORIDE/...ENHANCES ACTION OF...ANALGESICS & ANESTHETICS. /HYDROCHLORIDE/.../REPORTED/ TO PROTECT EXPTL ANIMALS AGAINST HEPATOTOXIC EFFECTS OF CARBON TETRACHLORIDE...PHYSOSTIGMINE WAS GIVEN TO 17 PT INLABOR PREVIOUSLY GIVEN SCOPOLAMINE ALONE OR MEPERIDINE & PROPIOMAZINE IN COMBINATION, TO ASCERTAIN ITS EFFECT ON REVERSING THE LOSS OF FETAL HEART RATE VARIABILITY. WITH MEPERIDINE & PROPIOMAZINE COMBINATION, REVERSION OCCURRED IN 10 PT. |
| Gesundheitliche Auswirkungen | They cause slurred speech, disorientation and "drunken" behavior. They are physically and psychologically addictive. |
| Toxizitätsübersicht | Propiomazine is an antagonist at types 1, 2, and 4 dopamine receptors, serotonin (5-HT) receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Its main use as a sedative is due to its antihistamine effect. |
| Signs and Symptoms | Rare, serious side effects include convulsions (seizures)difficult or unusually fast breathingfast or irregular heartbeat or pulsefever (high)high or low blood pressureloss of bladder controlmuscle stiffness (severe)unusual increase in sweatingunusually pale skinand unusual tiredness or weakness. |
| Human Toxicity Excerpts | SEE PROMETHAZINE. ...CASE IS REPORTED OF 2-YR-OLD CHILD WHO INGESTED 250 MG WITH RESULTING CONFUSION, CONVULSIONS, & STUPOR, BUT EVENTUAL RECOVERY. /PROMETHAZINE/ |
Anwendungen & Verwendung
Verwenden
Propiomazine is used in the preparation of analgesics as well as maintaining its own analgesic effects whilst applied to various neurological diseases.