HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Disoprofol
2,6-DIISOPROPYLPHENOL · DIPRIVAN · Propofol USP · Anepol · Ivofol · PD18215 · AMpofol · Aquafol
Identifikatoren & physikalische Daten
| CAS No. | 2078-54-8 |
|---|---|
| Summenformel | C12H18O |
| Durchschnittliche Molmasse | 178,27 g/mol |
| Monoisotopische Masse | 178,1357652 g/mol |
| SMILES | CC(C)c1cccc(C(C)C)c1O |
| InChIKey | OLBCVFGFOZPWHH-UHFFFAOYSA-N |
| PubChem CID | 4943 |
| ChEMBL | CHEMBL526 |
| ChEBI | CHEBI:44915 |
| EC No. | 218-206-6 |
| DTXSID | DTXSID6023523 |
| Lokaler Name | Disoprofol |
Chemische & physikalische Eigenschaften
| XLogP | 3,8 |
|---|---|
| Polarare Oberfläche (TPSA) | 20,2 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 1 |
| Frei drehbare Bindungen | 2 |
| Schwere Atome | 13 |
| Formalladung | 0 |
| Komplexität | 135 |
| Arzneimittel | DEA NFLIS-Drug Category -> Depressants and TranquilizersPharmaceuticals -> Synthetic Cannabinoids or Psychoactive CompoundsPharmaceuticals -> AnestheticsPharmaceuticals -> Listed in ZINC15Pharmaceuticals -> Used in Switzerland |
| SpringerMaterials Properties | 13C nuclear magnetic resonance spectrum |
| LogP (Verteilungskoeffizient) | log Kow = 3.794 |
| Dichte | 0.955 g/cu cm @ 20 °C0.962 g/mL at 25 °C (lit.) |
| Color/Form | Light-straw-colored liquid |
| Löslichkeit | Insoluble in water. Soluble in alcohol and toluene.1.58e-01 g/LVery slightly soluble in water, miscible with hexane and with methanolVery slightly soluble in water. |
| Human Drugs | Breast FeedingLactationAnesthetics, IntravenousHypnotics and SedativesFDA approved drugs -> Active ingredientPharmaceuticalsGeneral anaesthetics and oxygen > Injectable medicines |
| Animal Drugs | Active Ingredients (Propofol) -> FDA Greenbook |
| Siedepunkt | 242 °C254.00 to 256.00 °C. @ 764.00 mm Hg256 °C/764 mmHg (lit.) |
| Schmelzpunkt | 18 °C18 °C (lit.) |
| Brechungsindex | Index of refraction (sodium light): 1.5134 @ 20 °C1.5111 @ 25 °C.n20/D 1.514(lit.) |
| Physical Description | Liquid |
| Dampfdruck | 5.6 mm Hg ( 100 °C) |
| Flammpunkt | >230 °F |
| Lagerbedingungen | 2-8°C |
| pKa (Säurekonstante) | pKa 11.10(H2O,t =20)(Approximate) |
| Aggregatzustand | 18°C Liquid |
| Farbe | Pale Yellow to Yellow |
| Geruch | at 100.00%. mild phenolic |
| Merck | 14,7834 |
| BRN | 1866484 |
| Henry-Konstante | 4.7×100 mol/(m3Pa) at 25℃, HSDB (2015) |
| Hauptanwendungen | cleaning productscosmeticsflavors and fragrancesfood and beveragespersonal care |
| InChI | 1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3 |
| InChIKey | OLBCVFGFOZPWHH-UHFFFAOYSA-N |
| SMILES | CC(C)c1cccc(C(C)C)c1O |
| LogP (Verteilungskoeffizient) | 3.790 |
| CAS Datenbank | 2078-54-8(CAS DataBase Reference) |
| NIST chemische Informationen | Phenol, 2,6-bis(1-methylethyl)-(2078-54-8) |
| EPA chemische Informationen | 2,6-Diisopropylphenol (2078-54-8) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 1494 reports by companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | Chemical: Phenol, 2,6-bis(1-methylethyl)-Phenol, 2,6-bis(1-methylethyl)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Phenol, 2,6-bis(1-methylethyl)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Propofol: Does not have an individual approval but may be used under an appropriate group standard |
| FDA-Anforderungen | The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl propofol, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.Propofol injection. (a) Specifications. The drug is a sterile, nonpyrogenic, oil-in-water emulsion containing 10 milligrams of propofol per milliliter. ... (1) Dogs. (i) The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for procedures lasting up to 5 minutesfor induction and maintenance of general anesthesia using incremental doses to effectfor induction of general anesthesia where maintenance is provided by inhalant anesthetics. ... (2) Cats. (i) The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for short procedures, for induction and maintenance of general anesthesia using incremental doses to effect, and for induction of general anesthesia where maintenance is provided by inhalant anesthetics. |
| Hazard Classes and Categories | Acute Tox. 4 (100%) |
| Entsorgungsverfahren | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
Anwendungen & Verwendung
Beschreibung
Propofol is an injectable, short-acting general anesthetic with a low incidence of side effects.
History
Propofol, anesthetic drug used to induce and maintain general anesthesia and to sedate patients for certain medical procedures. Propofol was first tested clinically in 1977. When administered by intravenous injection, it quickly induced anesthesia, with fast and smooth recovery afterward. Animal studies, however, revealed the potential for severe allergic reactions. With subsequent reformulation of propofol into an oil-based emulsion, giving it a milky appearance, this challenge was overcome, and propofol gained widespread use as a key anesthetic agent.
Verwenden
Propofol is an anesthetic used in veterinary medicine.