3,5-dimethyl PIT-1
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Grundinformationen
- CAS
701947-53-7- Standard-SMILES
Cc1cc(C)cc(C(=O)NC(=S)Nc2cc([N+](=O)[O-])ccc2O)c1- InChIKey
CGWBCAQMXJFWBU-UHFFFAOYSA-N- Summenformel
- C16H15N3O4S
- Durchschnittliche Molmasse
- 345,37 g/mol
Namen und Bezeichner
- Bevorzugter Name
- 3,5-dimethyl PIT-1
- Englischer Name
- 3,5-dimethyl PIT-1
- Summenformel
- C16H15N3O4S
- Molmasse
- 345.37
Namen und Synonyme
DM-PIT-13,5-dimethyl PIT-1PIP3 Antagonist II, DM-PIT-1DM-PIT-1 (3,5-dimethyl PIT-1)3,5 dimethyl PIT 1,3,5dimethyl PIT13,5-dimethyl PIT-1, PIP3/protein binding inhibitorPIP3 Antagonist II, DM-PIT-1 - CAS 701947-53-7 - CalbiochemN-[(2-hydroxy-5-nitrophenyl)carbamothioyl]-3,5-dimethylbenzamideBenzamide, N-[[(2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-3,5-dimethyl-
Datenbank-Bezeichner
- CAS
701947-53-7- PubChem CID
- 4999938
- ChEMBL
CHEMBL3596524- UNII
- 6LVW9S79CB
- Nikkaji
- J2.971.757E
Eigenschaften
Physikochemische Eigenschaften
- storage temp.
- 2 C · +2C to +8C
- Löslichkeit
- 30 · DMF:30.0(Max Conc. mg/mL);86.86(Max Conc. mM)DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.45(Max Conc. mM)DMSO:20.0(Max Conc. mg/mL);57.91(Max Conc. mM)Ethanol:0.2(Max Conc. mg/mL);0.58(Max Conc. mM)
- Aggregatzustand
- Off-white powder
- Farbe
- off-white
- InChI
- 1S/C16H15N3O4S/c1-9-5-10(2)7-11(6-9)15(21)18-16(24)17-13-8-12(19(22)23)3-4-14(13)20/h3-8,20H,1-2H3,(H2,17,18,21,24)
- InChIKey
- CGWBCAQMXJFWBU-UHFFFAOYSA-N
- SMILES
- OC(C=CC([N+]([O-])=O)=C1)=C1NC(NC(C2=CC(C)=CC(C)=C2)=O)=S
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- WGK 3
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Anwendungen
BeschreibungPtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking and initiates an intricate signaling cascade that has been implicated in cancer. 3,5-dimethyl PIT-1 is a dimethyl analog of PIT-1, the selective inhibitor of PIP3/Akt PH domain binding, that is designed for more favorable solubility in vivo. 3,5-dimethyl PIT-1 inhibits PI3K/Akt signaling (IC50 = 27 μM), suppressing PI3K-PDK1-Akt-dependent phosphorylation, which has been shown to reduce cell viability and induce apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 36 μM). 4T1 breast cancer growth is significantly attenuated in BALB/c mice with a dose of 1 mg/kg of 3,5-dimethyl PIT-1 per day.
Anbieter10 Anbieter
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
Aladdin Scientific[email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司021-61415566 800-8193336 · [email protected]
上海一研生物科技有限公司021-69985186 13611928337 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
上海宏叶生物科技有限公司400-9205774 400-920-5774 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
ChemeGen 中国18818260767 · [email protected]
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