Repirinast
Grundinformationen
- CAS
73080-51-0- Standard-SMILES
Cc1ccc2c([nH]c(=O)c3c(=O)cc(C(=O)OCCC(C)C)oc32)c1C- InChIKey
NFQIAEMCQGTTIR-UHFFFAOYSA-N- Summenformel
- C20H21NO5
- Durchschnittliche Molmasse
- 355,4 g/mol
- Monoisotopische Masse
- 355,14197277
Überblick
Repirinast is an organic molecular entity.
Namen und Bezeichner
- Bevorzugter Name
- Repirinast
- IUPAC
- 3-methylbutyl 7,8-dimethyl-4,5-dioxo-6H-pyrano[3,2-c]quinoline-2-carboxylate
- Englischer Name
- Repirinast
- Summenformel
- C20H21NO5
- Molmasse
- 355.38
Namen und Synonyme
repirinast73080-51-0MY-5116Repirinastum4K8KA8B61GDTXSID10223349Isoamyl 5,6-dihydro-7,8-dimethyl-4,5-dioxo-4H-pyrano(3,2-c)quinoline-2-carboxylateRefChem:930657DTXCID60145840RometIsopentyl 7,8-dimethyl-4,5-dioxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-2-carboxylate3-methylbutyl 7,8-dimethyl-4,5-dioxo-6H-pyrano[3,2-c]quinoline-2-carboxylate
Weitere Namen anzeigen
RepirinasRui Pi Si TeRepirinast (>Repirinast (>80%)Repirinast USP/EP/BP3-Methylbutyl 7,8-dimethyl-4,5-dioxo-6H-pyrano[5,6-c]quinoline-2-carboxylate
Repirinast (>80%)Repirinastum [INN-Latin]Repirinast [USAN:INN:JAN]BRN 4267921UNII-4K8KA8B61GRomet (TN)REPIRINAST [MI]REPIRINAST [INN]
Datenbank-Bezeichner
- CAS
73080-51-0- PubChem CID
- 5050
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 3,4
- Polarare Oberfläche (TPSA)
- 81,7 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 5
- Frei drehbare Bindungen
- 5
- Schwere Atome
- 26
- Formalladung
- 0
- Komplexität
- 690
Physikochemische Eigenschaften
- Schmelzpunkt
- 236 · 236-241°
- Siedepunkt
- 488.42 °C · 488.42°C (rough estimate)
- Dichte
- 1.2749 · 1.2749 (rough estimate)
- Brechungsindex
- 1.6 · 1.6000 (estimate)
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- DMSO (Sparingly, Heated), Methanol (Slightly, Heated)
- Aggregatzustand
- Solid
- pka
- 10.09 · 10.09±0.40(Predicted)
- Farbe
- White to Off-White
- Wasserlöslichkeit
- 1.2 mg/L · 1.2mg/L(temperature not stated)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- Toxizität
- LD50 in rats, mice (mg/kg): >5000 orally, >5000 s.c. both species (Nagase)
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Anwendungen
BeschreibungRepirinast is an orally-active antiallergic agent useful in the treatment of allergic asthma. Its activity is reportedly attributed to a metabolite, the corresponding free acid (MY-1250), which is 17 times more potent than disodium cromoglycate in inhibiting histamine release due to antigen-antibody reactions.
VerwendenAntiallergic.
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Anbieter37 Anbieter
LIDE PHARMACEUTICALS LIMITED+852-55945652 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
武汉英诺医药科技有限公司
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