Bms-911543

HCID 50922691

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Grundinformationen

CAS: 1271022-90-2
Standard-SMILES: CCn1c(C(=O)N(C2CC2)C2CC2)cc2c3c(ncn3C)c(Nc3cc(C)n(C)n3)nc21
InChIKey: JCINBYQJBYJGDM-UHFFFAOYSA-N
Summenformel: C23H28N8O
Durchschnittliche Molmasse: 432,5 g/mol
Monoisotopische Masse: 432,23860752

Überblick

BMS-911543 has been used in trials studying the treatment of Cancer.

Namen und Bezeichner

Bevorzugter Name: Bms-911543
IUPAC: N,N-dicyclopropyl-7-[(1,5-dimethylpyrazol-3-yl)amino]-10-ethyl-3-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene-11-carboxamide
Englischer Name: BMS-911543
Summenformel: C23H28N8O
Molmasse: 432.52

Namen und Synonyme

BMS-9115431271022-90-2BMS 911543JAK2 INHIBITOR BMS-9115437N03P021J8DTXSID00155403RefChem:120755DTXCID1077894N,N-dicyclopropyl-7-((1,5-dimethyl-1H-pyrazol-3-yl)amino)-10-ethyl-3-methyl-3,5,8,10-tetraazatricyclo(7.3.0.0^(2,6))dodeca-1,4,6,8,11-pentaene-11-carboxamideBMS911543MFCD22200575N,N-dicyclopropyl-4-((1,5-dimethyl-1H-pyrazol-3-yl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide

Weitere Namen anzeigen

CS-785BMS-911543 ，S7144BMS-911543, 10 mM in DMSOJanus kinase,inhibit,BMS 911543,Inhibitor,JAK,BMS-911543N,N-Dicyclopropyl-4-((1,5-dimethyl-1H-pyrazol-3-yl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo[N,N-Dicyclopropyl-4-[(1,5-dimethyl-1H-pyrazol-3-yl)amino]-6-ethyl-1,6-dihydro-1-methyl-imidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide

Imidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide, N,N-dicyclopropyl-4-[(1,5-dimethyl-1H-pyrazol-3-yl)amino]-6-ethyl-1,6-dihydro-1-methyl-N,N-Dicyclopropyl-4-[(1,5-Dimethyl-1h-Pyrazol-3-Yl)amino]-6-Ethyl-1-Methyl-1,6-Dihydroimidazo[4,5-D]pyrrolo[2,3-B]pyridine-7-CarboxamideN,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamideN,N-dicyclopropyl-7-[(1,5-dimethylpyrazol-3-yl)amino]-10-ethyl-3-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene-11-carboxamideUNII-7N03P021J8JCINBYQJBYJGDM-UHFFFAOYSA-NIMIDAZO(4,5-D)PYRROLO(2,3-B)PYRIDINE-7-CARBOXAMIDE, N,N-DICYCLOPROPYL-4-((1,5-DIMETHYL-1H-PYRAZOL-3-YL)AMINO)-6-ETHYL-1,6-DIHYDRO-1-METHYL-THCYT3

Datenbank-Bezeichner

CAS: 1271022-90-2
PubChem CID: 50922691
DTXSID: DTXSID00155403
ChEMBL: CHEMBL3545215
UNII: 7N03P021J8
Nikkaji: J3.419.274J

Eigenschaften

Berechnete Struktureigenschaften

XLogP: 2,9
Polarare Oberfläche (TPSA): 85,8 Å²
H-Brücken-Donoren: 1
H-Brücken-Akzeptoren: 5
Frei drehbare Bindungen: 6
Schwere Atome: 32
Formalladung: 0
Komplexität: 717

Experimentelle und physikochemische Eigenschaften

DrugsPharmaceuticals -> Listed in ZINC15

Physikochemische Eigenschaften

storage temp.: 2 · under inert gas (nitrogen or Argon) at 2–8 °C
Löslichkeit: 43.3 mg/mL · ≥43.3 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥9.8 mg/mL in EtOH with gentle warming and ultrasonic
Aggregatzustand: Powder
Farbe: White to light yellow