5-((4-Hydroxyphenyl)methylene)-2,4-thiazolidinedione

(Z)-5-(4-hydroxybenzylidene)thiazolidine-2,4-dione · Pioglitazone Impurity 42 · 5-(4-hydroxybenzylidene)-2,4-thiazolidinedione · 5-[(4-hydroxyphenyl)methylene]-2,4-Thiazolidinedione · 2,4-Thiazolidinedione, 5-[(4-hydroxyphenyl)methylene]- · (Z)-5-(4-hydroxybenzylidene)thiazolidine-2,4-dione(WX180325) · Pioglitazone impurity 5-(4-Hydroxybenzylidene)thiazolidine-2,4-dione

https://huagongshe.com/de/chemical/517822

Molekülstruktur von 5-((4-Hydroxyphenyl)methylene)-2,4-thiazolidinedione

Identifikatoren & physikalische Daten

CAS No.	103788-60-9
Summenformel	C10H7NO3S
Durchschnittliche Molmasse	221,23 g/mol
SMILES	O=C1NC(=O)C(=Cc2ccc(O)cc2)S1
InChIKey	ARHIHDVVUHVQCP-UHFFFAOYSA-N
PubChem CID	517822
EC No.	104-841-5

Chemische & physikalische Eigenschaften

XLogP	1,8
Polarare Oberfläche (TPSA)	91,7
H-Brücken-Donoren	2
H-Brücken-Akzeptoren	4
Frei drehbare Bindungen	1
Schwere Atome	15
Formalladung	0
Komplexität	319

Sicherheit & Vorschriften

GHS-Einstufung	WarningH319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement)The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Hazard Classes and Categories	Eye Irrit. 2 (100%)
Gefahrenklasse	IRRITANT

Anwendungen & Verwendung

Verwenden

5-[(4-Hydroxyphenyl)methylene]-2,4-thiazolidinedione is a 5-Benzylidene-2,4-thiazolidenedione derivative designed as inhibitors of angiogenesis targeting VEGFR-2. Also, it is an intermediate used in the synthesis of MSDC 0602 (M755420), which is an analogue ofthiazolidinediones, exhibits low affinity for binding and activation of peroxisome proliferator-activated receptor γ (PPARγ). Thiazolidinediones are effective insulin-sensitizing drugs for treating various metabolic and inflammatory diseases.