2,3,4,9-Tetrahydro-2-methyl-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridin
Setiptiline
Grundinformationen
- CAS
57262-94-9- Standard-SMILES
CN1CCC2=C(C1)c1ccccc1Cc1ccccc12- InChIKey
GVPIXRLYKVFFMK-UHFFFAOYSA-N- Summenformel
- C19H19N
- Durchschnittliche Molmasse
- 261,4 g/mol
- Monoisotopische Masse
- 261,15174961
Überblick
Setiptiline is a tetracyclic antidepressant that is 2,3,4,9-tetrahydro-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine carrying a methyl group at position 2. Its maleate salt is used for the treatment of depression in Japan. It has a role as an alpha-adrenergic antagonist and a serotonergic antagonist. It is a tetracyclic antidepressant and a tertiary amino compound. It is a conjugate base of a setiptiline(1+).
Namen und Bezeichner
- Bevorzugter Name
- Setiptiline
- IUPAC
- 4-methyl-4-azatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),2(7),8,10,12,15,17-heptaene
- Lokaler Name
- 2,3,4,9-Tetrahydro-2-methyl-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridin
- Englischer Name
- Setiptiline
- Summenformel
- C19H19N
- Molmasse
- 261.36
Namen und Synonyme
Setiptiline57262-94-9Org-8282SetiptilinaORG 8282SetiptilinumMO 8282DTXSID50205886MO-82827L38105Z6ECHEBI:13507613b,4a-carba-mianserin
Weitere Namen anzeigen
TecipulTeciptilineTeciptillineSetiptiline USP/EP/BPSetiptiline (TeciptilineSetiptiline(Teciptilline)TECIPTILLINEORG82822，3，4，9-Tetmhydro-2-methyl-1H-dibenzo[3，4：6，7]cyelohepta[1，2-c]pyridine
RefChem:1826171,2,3,4-tetrahydro-2-methyl-9H-dibenzo(3,4-6,7)cyclohepta(1,2-C)pyridineDTXCID80128377260-653-44-methyl-4-azatetracyclo(13.4.0.02,?.0?,13)nonadeca-1(19),2(7),8,10,12,15,17-heptaeneSetiptiline [INN]4-methyl-4-azatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),2(7),8,10,12,15,17-heptaene2,3,4,9-Tetrahydro-2-methyl-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine
Datenbank-Bezeichner
- CAS
57262-94-9- PubChem CID
- 5205
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 3,3
- Polarare Oberfläche (TPSA)
- 3,2 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 1
- Frei drehbare Bindungen
- 0
- Schwere Atome
- 20
- Formalladung
- 0
- Komplexität
- 397
Experimentelle und physikochemische Eigenschaften
DrugsPharmaceuticals -> Listed in ZINC15
Endocrine DisruptorsPotential endocrine disrupting compound
Physikochemische Eigenschaften
- Schmelzpunkt
- 120 °C · >120°C (dec.)
- Siedepunkt
- 421.7 · 421.7±34.0 °C(Predicted)
- Dichte
- 1.15 · 1.15
- storage temp.
- -20 °C · Sealed in dry,Store in freezer, under -20°C
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 8.34 · 8.34±0.20(Predicted)
- Farbe
- White to Light Yellow
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- Alarmwort
- Warnung
- Gefahrenhinweise
- Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H315
Chemie und Industrie
Pharmakologische Informationen
PharmacodynamicsSetiptiline is a tertacyclic antidepressant. It acts to reduce the symptoms of major depressive disorder.
Mechanism of Action
Setiptiline is an antagonist at the α2 adrenergic receptor and at serotonin receptors. The antagonism of the α2 receptors likely relieves presynaptic inhibition of adrenergic neurotransmission, allowing for greater and longer sustained release of noradrenaline into the synapse. The antagonism of serotonin receptors may produce an upregulation of the receptors leading to an eventual increase in serotonergic signalling. The actual physiological mechanisms behind the antidepressant effect of setiptiline is unknown but the listed possibilities exist as likely explanations.
Anwendungen
BeschreibungSetiptiline is a mianserin analog reportedly useful in the treatment of depression with a favorable side-effect profile. It is a potent antagonist of alpha-receptors, with greater affinity at alpha, than alpha, sites, as well as an inhibitor of central serotonin receptors.
VerwendenSetiptiline is a tetracyclic antidepressant. Setiptiline acts as a noradrenergic and specific serotonergic antidepressant (NaSSA).
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Anbieter30 Anbieter
LGM Pharma1-(800)-881-8210 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
Zugehörige Reaktionen
0
Keine Reaktionsaufzeichnungen unter den aktuellen Filterkriterien.
Notizen zur Verbindung
Wird geladen…