Sobuzoxane
Grundinformationen
- CAS
98631-95-9- Standard-SMILES
CC(C)COC(=O)OCN1C(=O)CN(CCN2CC(=O)N(COC(=O)OCC(C)C)C(=O)C2)CC1=O- InChIKey
OCOKWVBYZHBHLU-UHFFFAOYSA-N- Summenformel
- C22H34N4O10
- Durchschnittliche Molmasse
- 514,5 g/mol
- Monoisotopische Masse
- 514,22749329
Überblick
Sobuzoxane is an organic molecular entity.
Namen und Bezeichner
- Bevorzugter Name
- Sobuzoxane
- IUPAC
- [4-[2-[4-(2-methylpropoxycarbonyloxymethyl)-3,5-dioxopiperazin-1-yl]ethyl]-2,6-dioxopiperazin-1-yl]methyl 2-methylpropyl carbonate
- Englischer Name
- Sobuzoxane
- Summenformel
- C22H34N4O10
- Molmasse
- 514.53
Namen und Synonyme
sobuzoxane98631-95-9MST-16SobuzoxanoSobuzoxanumDTXSID5045203R1308VH37P1,2-Bis(4-isobutoxycarbonyloxymethyl-3,5-dioxo-piperazin-1-yl)ethaneDTXCID3025203RefChem:1834921,2-bis(4-isobutoxycarbonyloxymethyl-3,5-dioxopiperazin-1-yl)ethaneMST 16
Weitere Namen anzeigen
e)(ester)PerazolineSobuzoxane/MST 16methylpropyl)ester4,4’-ethylenebis(1-(hydroxymethyl)-2,6-piperazinedione)bis(isobutylcarbonat1,2-ethanediylbis((2,6-dioxo-4,1-piperazinediyl)methylene)bis(2-carbonicaci4,4'-Ethylenebis(2,6-dioxopiperazine-1-methanol)bis(2-methylpropoxyformate)MST-16, 4,4μ-(1,2-Ethanediyl)bis(1-isobutoxycarbonyloxmethyl-2,6-piperazinedione)
[4-[2-[4-(2-methylpropoxycarbonyloxymethyl)-3,5-dioxopiperazin-1-yl]ethyl]-2,6-dioxopiperazin-1-yl]methyl 2-methylpropyl carbonateMFCD00866498PerazolinSobuzoxane (JAN)NCGC00015954-02SOBUZOXANE [JAN]Sobuzoxane [INN:JAN]Sobuzoxanum [INN-Latin]
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 2
- Polarare Oberfläche (TPSA)
- 152 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 12
- Frei drehbare Bindungen
- 15
- Schwere Atome
- 36
- Formalladung
- 0
- Komplexität
- 743
Physikochemische Eigenschaften
- Schmelzpunkt
- 128 · 128-130°; mp 132-133° (Cai, 1989)
- Siedepunkt
- 664.9 · 664.9±55.0 °C(Predicted)
- Dichte
- 1.272 · 1.272±0.06 g/cm3(Predicted)
- Löslichkeit
- 19 mg/mL · DMSO: 19 mg/mL
- Aggregatzustand
- solid
- pka
- 2.75 · 2.75±0.20(Predicted)
- Farbe
- White to off-white
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 2
- RTECS-Nr.
- FG1582500
- Toxizität
- LD50 in male, female mice, rats (mg/kg): 807, 960, 877, 567 i.p.; 400, 673, 3025, 2821 s.c.; >5 g/kg orally in all species (Tokiwa)
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.
Anwendungen
BeschreibungSobuzoxane, a novel bis(2,6-dioxopiperazine) derivative, was introduced in Japan for the treatment of malignant lymphoma and adult T-cell IeukemiaQmphoma (ATLL), which is resistant to chemotherapy and has a poor prognosis. Sobuzoxane exhibits 8 broad spectrum of antitumor activity. It is a noncleavable complexstabilizing topoisomerase II inhibitor and exerts its function via interfering with the catalytic activity of the enzyme to result in an irreversible inhibition of cell division by blockade of chromosome condensation and segregation. Due to Its unique mode of cytocidai activity, it has no cross resistance with many currently available anticancer agents. Sobuzoxane is reported to significantly inhibit growth of human colon, lung, gastric, and breast cancers and is in clinical trials for these indications.
VerwendenSobuzoxane is an inhibitor of DNA topoisomerase II which induces apoptosis.
Anbieter6 Anbieter
Aladdin Scientific[email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
TargetMol 中国（陶术生物）400-821-0310 15002144251 · [email protected]
武汉杂环科技有限公司027-88041443 13072715837 · [email protected]
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