Natriumiodid

3.67

3.67 g/cm³

3.667 @25 °C

COLORLESS, CUBIC CRYSTALS

WHITE CRYSTALS OR GRANULES

WHITE POWDER

Soluble

SOLUBILITY (G/100 CC SOLVENT): 184 G IN WATER @ 25 °C; 302 G IN WATER @ 100 °C; 42.57 G IN ALCOHOL @ 25 °C; 39.9 G IN ACETONE @ 25 °C

1 G SOL IN 1 ML GLYCEROL

Solubility in water, g/100ml at 25 °C: 184

Decomposes

1304 °C

1304 °C

1304 °C @760 [mm Hg]

This chemical does not meet GHS hazard criteria for 7.9% (39 of 495) of reports.

Danger

H315 (70.9%): Causes skin irritation [Warning Skin corrosion/irritation]

P260, P261, P264, P264+P265, P270, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 495 reports by companies from 36 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Chemical: Sodium iodide (NaI)

Sodium iodide (NaI) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Sodium iodide (NaI) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

REACH registered substance: Sodium iodide (EC: 231-679-3)

Sodium iodide: Does not have an individual approval but may be used under an appropriate group standard

A skin, eye, and respiratory tract irritant; If ingested: the substance may have effects on the thyroid and may cause systemic sensitization. Symptoms of systemic sensitization may include airway obstruction and various skin reactions or even anaphylactic shock. Exposure during pregnancy may affect the thyroid function of the newborn. [ICSC] An irritant; [MSDSonline] See Iodine for the TLV of Iodides.

RESPONSE TO IODIDE IN HYPERTHYROIDISM: /IN THYROID GLAND/...VASCULARITY IS REDUCED, GLAND BECOMES MUCH FIRMER & EVEN HARD TO THE TOUCH, CELLS BECOME SMALLER, COLLOID REACCUMULATES IN FOLLICLES, & QUANTITY OF BOUND IODINE INCREASES. /IODIDES/

HIGH CONCN OF IODIDE APPEAR TO INFLUENCE ALL IMPORTANT ASPECTS OF IODINE METABOLISM BY THE THYROID GLAND. CAPACITY OF IODIDE TO LIMIT ITS OWN TRANSPORT... ACUTE INHIBITION OF SYNTHESIS OF IODOTYROSINE & IODOTHYRONINE BY IODIDE IS ALSO WELL KNOWN (THE WOLFF-CHAIKOFF EFFECT)... /IODIDES/

THIS INHIBITION /WOLFF-CHAIKOFF EFFECT/ IS OBSERVED ONLY ABOVE CRITICAL CONCN OF IODIDE, & THE INTRACELLULAR...CONCN OF ANION APPEARS TO BE MAJOR DETERMINANT. WITH TIME THERE IS "ESCAPE" FOR THIS INHIBITION...ASSOCIATED WITH AN ADAPTIVE DECR IN IODIDE TRANSPORT & LOWERED INTRACELLULAR IODIDE CONCN. /IODIDES/

THE MOST IMPORTANT CLINICAL EFFECT OF HIGH IODIDE CONCN IS AN INHIBITION OF THE RELEASE OF THYROID HORMONE. THIS ACTION IS RAPID & EFFICACIOUS IN SEVERE THYROTOXICOSIS. THE EFFECT IS EXERTED DIRECTLY ON THE THYROID GLAND, & IT CAN BE DEMONSTRATED IN EUTHYROID SUBJECT & EXPTL ANIMALS AS WELL AS IN HYPERTHYROID PT. /IODIDES/

IODIDE ANTAGONIZES THE ABILITY OF BOTH THYROTROPIN & CYCLIC AMP TO STIMULATE ENDOCYTOSIS OF COLLOID, PROTEOLYSIS, & HORMONE SECRETION. /REPORTEDLY/... IODIDE ATTENUATES THE EFFECT OF TSH ON CYCLIC AMP IN VIVO & IN ISOLATED TISSUES. /IODIDES/

Iodide salts are readily absorbed in the gastrointestinal tract.

Iodides are expected to be renal excreted.

Iodides are distributed widely throughout extracellular fluid of thyroid gland.

Used in small amounts for wet extraction of silver; Also used in iodized salt and for various applications in human and veterinary medicine; [HSDB] Used in photography, cloud seeding, and as a solvent for iodine; [Hawley]