Grundinformationen
- Standard-SMILES
CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1.O=C(O)/C=C\C(=O)O- InChIKey
SUFUKZSWUHZXAV-BTJKTKAUSA-N- Summenformel
- C22H23N3O7S
- Durchschnittliche Molmasse
- 473,5 g/mol
- Monoisotopische Masse
- 473,12567108
Überblick
Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Rosiglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation.
Namen und Bezeichner
- Bevorzugter Name
- Rosiglitazone Maleate
- IUPAC
- (Z)-but-2-enedioic acid;5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
Namen und Synonyme
Rosiglitazone maleate155141-29-0BRL-49653CRosiglitzazone maleateDTXSID2023569BRL 49653CBRL-49653-CNSC-717764KX2339DP44DTXCID7035692,4-Thiazolidinedione, 5-((4-(2-(methyl-2-pyridinylamino)ethoxy)phenyl)methyl)-, (2Z)-2-butenedioate (1:1)NSC717764
Weitere Namen anzeigen
CHEBI:88922,4-Thiazolidinedione, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-, (2Z)-2-butenedioate (1:1)RefChem:56530(+-)-5-((4-(2-(Methyl-2-pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedione, (Z)-2-Butenedioate (1:1)AvandiaRosiglitazone Maleate [USAN]MFCD03427306Rosiglitazone (maleate)
Datenbank-Bezeichner
- CAS
155141-29-0- PubChem CID
- 5281055
- DTXSID
DTXSID2023569- ChEMBL
CHEMBL843- UNII
- KX2339DP44
- EC Number
- 642-163-6
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 171 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 10
- Frei drehbare Bindungen
- 9
- Schwere Atome
- 33
- Formalladung
- 0
- Komplexität
- 587
Experimentelle und physikochemische Eigenschaften
Solubility68.2 [ug/mL] (The mean of the results at pH 7.4)
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Sicherheit und Regulatorisches
GHS-Klassifizierung
GHS Classification
Warning
H302 (20%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 5 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesEye Irrit. 2 (60%)
Toxikologische Informationen
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Rosiglitazone maleate
vLess-DILI-concern
3
Warnings & precautions
DOI:10.1016/j.drudis.2016.02.015
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological ClassificationSubstances which lower blood glucose levels.
Zugehörige Reaktionen
5
Verknüpfte Notizen
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