trans-2-Hexenal

Other Classes -> Aldehydes

Other Classes -> Aldehydes

EU Flavoring substances

EU Flavoring substances

Soluble in propylene glycol and most fixed oils; Very slightly soluble in water

Soluble (in ethanol)

47.00 °C. @ 17.00 mm Hg

47 °C (17mm Hg)

6.6 [mmHg]

6.6 [mmHg]

CBI; Liquid

Clear light yellow liquid; [Sigma-Aldrich MSDS]

Pale yellow to colourless oily liquid; Strong fruity, green, vegetable-like aroma

Danger

H226 (96.6%): Flammable liquid and vapor [Warning Flammable liquids]

P210, P233, P240, P241, P242, P243, P261, P262, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P303+P361+P353, P305+P351+P338, P316, P321, P330, P333+P317, P337+P317, P361+P364, P362+P364, P370+P378, P391, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 1801 reports by companies from 29 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

This chemical does not meet GHS hazard criteria for 0.7% (1 of 150) of reports.

Danger

Chemical: 2-Hexenal

Chemical: 2-Hexenal, (E)-

Commission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)

Regulation (EC) No 1831/2003 (amended)

2-Hexenal, (2E)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Hexenal, (2E)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 27-11-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/25168

IMAP assessments - 2-Hexenal: Human health tier II assessment

IMAP assessments - 2-Hexenal: Human health tier II assessment

Safe when used as a flavoring agent in food; [JECFA] See 2-Pentenal and 2,4-Hexadienal.

Safe when used as a flavoring agent in food; [JECFA] A skin and strong eye irritant; May cause skin sensitization; Harmful by ingestion; Toxic by skin absorption; [Sigma-Aldrich MSDS]

2-Hexenal

D*: Other compounds that may form peroxides

Bretherick's

Flam. Liq. 3 (96.6%)

Flam. Liq. 3 (99.3%)

Acute toxicity (ingestion) - category 4

Acute toxicity (ingestion) - category 4

Uremic toxins such as 2-Hexenal are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stimulate the production of reactive oxygen species. This seems to be mediated by the direct binding or inhibition by uremic toxins of the enzyme NADPH oxidase (especially NOX4 which is abundant in the kidneys and heart) (A7868). Reactive oxygen species can induce several different DNA methyltransferases (DNMTs) which are involved in the silencing of a protein known as KLOTHO. KLOTHO has been identified as having important roles in anti-aging, mineral metabolism, and vitamin D metabolism. A number of studies have indicated that KLOTHO mRNA and protein levels are reduced during acute or chronic kidney diseases in response to high local levels of reactive oxygen species (A7869).

As a uremic toxin, this compound can cause uremic syndrome. Uremic syndrome may affect any part of the body and can cause nausea, vomiting, loss of appetite, and weight loss. It can also cause changes in mental status, such as confusion, reduced awareness, agitation, psychosis, seizures, and coma. Abnormal bleeding, such as bleeding spontaneously or profusely from a very minor injury can also occur. Heart problems, such as an irregular heartbeat, inflammation in the sac that surrounds the heart (pericarditis), and increased pressure on the heart can be seen in patients with uremic syndrome. Shortness of breath from fluid buildup in the space between the lungs and the chest wall (pleural effusion) can also be present.

Used as flavoring agent or adjuvant; [FDA]

Product of lipid peroxidation in the rat liver; a green odor chemical. [ChemIDplus] Permitted for use as an inert ingredient in non-food pesticide products; [EPA]

Concentrations in cosmetic products in the EU can not exceed 0.002%, based on sensitization reactions observed at 0.2% but not at 0.02%; [EC: SCCNFP]

Naturally produced by the body (endogenous).

2-Hexenal

2-Hexenal; trans-2-Hexenal; 2-Hexenal, (E)-; Hexen-2-al; Hex-2-enal; Leaf aldehyde; beta-Propyl acrolein; cis-2-Hexenal; 2-Hexenal, (Z)-

IFRA_STD_039.pdf

51

IFRA 51st Amendment - Guidance for the use of IFRA Standards

Restriction: This material should be used only in the limited quantity as stated in the Standard

Fragrance Ingredients

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Flavoring Agents -> JECFA Flavorings Index

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Other (requires additional information)

2-Hexenal: ACTIVE

2-Hexenal, (2E)-: ACTIVE

0.0014 [Products applied to the lips]

0.00041 [Products applied to the axillae]

0.0083 [Products applied to the face/body using fingertips]

0.0077 [Products related to fine fragrances]

0,0020 [Products applied to the body using the hands (palms), primarily leave-on (Body lotion)]

0,0020 [Products applied to the face using the hands (palms), primarily leave-on (Face moisturizer)]