[(1S,2R,7aR)-Hexahydro-2-hydroxy-1H-pyrrolizin-1-yl]methyl (2Z)-2-methyl-2-butenoate

BeschreibungA pyrrolizidine alkaloid, macrophylline has been isolated from Senecio amphibolus and S. macrophylla MB. It forms a low melting solid which has not yet been obtained in a crystalline form. The base is dextrorotatory having a specific rotation of [α]20D + 34.52° (c 1.68, EtOH). When hydrolyzed with dilute acids the base furnishes macronecine and angelic acid. It has been characterized as the crystalline bitartrate which melts at 162-4°C.