S-Hydroprene

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters: Wear self contained breathing apparatus for fire fighting if necessary.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas; Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided; Methods and materials for containment and cleaning up: Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging: Dispose of as unused product.

Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Normal measures for preventive fire protection.

Appropriate engineering controls: Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

A tolerance of 0.2 part per million is established for residues of hydroprene [(S)-(Ethyl (2E,4E,7S)-3,7,11-trimrthyl-2,4-dodecadienoate)], (CAS Reg. No. 65733-18-8) on food commodities in food-handling establishments in accordance with the following prescribed conditions: (1) Application shall be limited to spot, crack and crevice, perimeter and ultra low volume (ULV) fogging treatment in food storage or food-handling establishments, including warehouses, food service, manufacturing, and processing establishments such as restaurants, cafeterias, supermarkets, bakeries, breweries, dairies, meat slaughtering and packing plants, and canneries where food and food products are held, processed, and served: Provided that the food is removed or covered prior to such use, and food-processing surfaces are covered during treatment or thoroughly cleaned before using, or in the case of point-source device treatments, devices must not come into direct contact with food preparation surfaces and must be in a minimum distance of 3 feet from exposed foods. (2) To assure safe use of the insect growth regulator, the label and labeling shall conform to that registered by the U.S. Environmental Protection Agency, and it shall be used in accordance with such label and labeling.

Eye/face protection: Face shield and safety glasses. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection: Handle with gloves.

Body Protection: Complete suit protecting against chemicals. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 9320(SRC), determined from a structure estimation method(2), indicates that S-hydroprene is expected to be immobile in soil(SRC). Volatilization of S-hydroprene from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.2X10-5 atm-cu m/mole(SRC), based upon its vapor pressure, 3X10-4 mm Hg(3), and water solubility, 2.5 mg/L(3). However, adsorption to soil is expected to attenuate volatilization(SRC). S-Hydroprene is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Biodegradation data in soil were not available(SRC, 2016).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 9320(SRC), determined from a structure estimation method(2), indicates that S-hydroprene is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 4.2X10-5 atm-cu m/mole(SRC), derived from its vapor pressure, 3X10-4 mm Hg(4), and water solubility, 2.5 mg/L(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 39 hours and 17 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 19 months if adsorption is considered(5). S-Hydroprene is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). According to a classification scheme(6), an estimated BCF of 9030(SRC), from its log Kow of 6.5(4) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is very high, provided the compound is not metabolized by the organism(SRC). Biodegradation data in water were not available(SRC, 2016).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), S-hydroprene, which has a vapor pressure of 3X10-4 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase S-hydroprene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and ozone(SRC); the half-lives for these reactions in air are estimated to be 4.8 hours and 48 minutes(SRC), calculated from its respective rate constants of 8X10-11 and 3.4X10-16 cu cm/molecule-sec at 25 °C(SRC) that were derived using a structure estimation method(3). S-Hydroprene contains chromophores that absorb at wavelengths >290 nm(4) and, therefore, may be susceptible to direct photolysis by sunlight(SRC).

IDENTIFICATION AND USE: S-Hydroprene is an amber liquid (technical). It is an insect growth regulator. It inhibits normal molting processes causing mortality or sterility of insect at or before the final molt. HUMAN EXPOSURE AND TOXICITY: There are no data available. ANIMAL STUDIES: In a 13-week rat study using S-hydroprene, there were disturbances in hematological and clinical chemistry parameters, including prothrombin time (dose-related decrease in males). Increased liver, kidney and ovarian weights were observed at necropsy. Histopathologically, there was increased homogeneity of liver cytoplasm at high doses and in females, vacuolated interstitial cells in the ovaries. S-hydroprene was not carcinogenic in rats. In a multigeneration study in rats, using S-hydroprene, there was some evidence of an effect on seminiferous tubules in males, associated with an effect on fertility; it was unclear whether these effects were test-material related. S-hydroprene was not fetotoxic or teratogenic in rat. S-hydroprene was not mutagenic.

/OTHER TERRESTRIAL SPECIES/ Results of the histomorphological studies of the ovaries in normal Achoea janata are compared to the effects induced by the juvenoid, S-hydropene (312-006) on the ovaries. S-hydropene elicits various derangemental changes on the ovary when administered to O-day old pupae of Achoea janata S-hydroprene treatment also resulted in resorption of oocytes in the vitellarium and reduced the number of oocytes. Thus the treatment of S-hydropene indicates the possibility of reducing the reproductive potential of the female moth.

EPA has released the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays/[USEPA; ICSS Dashboard Application; Available from, as of July 7, 2016: http://actor.epa.gov/dashboard/]

Using a structure estimation method based on molecular connectivity indices(1), the Koc of S-hydroprene can be estimated to be 9320(SRC). According to a classification scheme(2), this estimated Koc value suggests that S-hydroprene is expected to be immobile in soil.

An estimated BCF of 9030 was calculated in fish for S-hydroprene(SRC), using a log Kow of 6.5(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is very high, provided the compound is not metabolized by the organism(SRC).

The Henry's Law constant for S-hydroprene is estimated as 4.2X10-5 atm-cu m/mole(SRC) derived from its vapor pressure, 3.0X10-4 mm Hg(1), and water solubility, 2.5 mg/L(1). This Henry's Law constant indicates that S-hydroprene is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 39 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 17 days(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 19 months if adsorption is considered(3). S-Hydroprene's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). S-Hydroprene is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ In a 13-week rat study using S-hydroprene, there were disturbances in hematological and clinical chemistry parameters, including prothrombin time (dose-related decrease in males). Increased liver, kidney and ovarian weights were observed at necropsy. Histopathologically, there was increased homogeneity of liver cytoplasm at high doses and in females, vacuolated interstitial cells in the ovaries.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ In a 4-week study in the rat, using the racemate, the main finding was increased liver weights (absolute and relative). /Neoprene/

/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ In a long-term/carcinogenicity study in rats using S-hydroprene... S-hydroprene was not carcinogenic.

/LABORATORY ANIMALS: Developmental or Reproductive Toxicity/ In a multigeneration study in rats, using S-hydroprene, there was some evidence of an effect on seminiferous tubules in males, associated with an effect on fertility; it was unclear whether these effects were test-material related.

For more Non-Human Toxicity Excerpts (Complete) data for S-Hydroprene (7 total), please visit the HSDB record page.

The rate constant for the vapor-phase reaction of S-hydroprene with photochemically-produced hydroxyl radicals has been estimated as 8X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 4.8 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). The rate constant for the vapor-phase reaction of S-hydroprene with ozone has been estimated as 3.4X10-16 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(1). This corresponds to an atmospheric half-life of about 48 minutes at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(2). S-Hydroprene is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). S-Hydroprene contains chromophores that absorb at wavelengths >290 nm(3) and, therefore, may be susceptible to direct photolysis by sunlight(SRC).

Occupational exposure to S-hydroprene may occur through inhalation and dermal contact with this compound at workplaces where S-hydroprene is produced or used. Use data indicate that the general population may be exposed to S-hydroprene via inhalation of sprays and dermal contact with consumer products containing S-hydroprene. (SRC)

S-Hydroprene's production may result in its release to the environment through various waste streams; its use as an insecticide will result in its direct release to the environment. If released to air, a vapor pressure of 3X10-4 mm Hg at 25 °C indicates S-hydroprene will exist solely as a vapor in the atmosphere. Vapor-phase S-hydroprene will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and ozone; the half-lives for these reactions in air are estimated to be 4.8 hours and 48 minutes, respectively. S-Hydroprene contains chromophores that absorb at wavelengths >290 nm and, therefore, may be susceptible to direct photolysis by sunlight. If released to soil, S-hydroprene is expected to have no mobility based upon an estimated Koc of 9320. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 4.2X10-5 atm-cu m/mole. However, adsorption to soil is expected to attenuate volatilization. S-Hydroprene is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Biodegradation data in soil or water were not available. If released into water, S-hydroprene is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 39 hours and 17 days, respectively. However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 19 months if adsorption is considered. An estimated BCF of 9030 suggests the potential for bioconcentration in aquatic organisms is very high, provided the compound is not metabolized by the organism. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions (pH 5 to 9). Occupational exposure to S-hydroprene may occur through inhalation and dermal contact with this compound at workplaces where S-hydroprene is produced or used. Use data indicate that the general population may be exposed to S-hydroprene via inhalation of sprays and dermal contact with consumer products containing S-hydroprene. (SRC)

A tolerance ... is established for residues of hydroprene [(S)-(Ethyl (2E,4E,7S)-3,7,11-trimrthyl-2,4-dodecadienoate)], (CAS Reg. No. 65733-18-8) on food commodities in food-handling establishments in accordance with the following prescribed conditions: (1) Application shall be limited to spot, crack and crevice, perimeter and ultra low volume (ULV) fogging treatment in food storage or food-handling establishments, including warehouses, food service, manufacturing, and processing establishments such as restaurants, cafeterias, supermarkets, bakeries, breweries, dairies, meat slaughtering and packing plants, and canneries where food and food products are held, processed, and served: Provided that the food is removed or covered prior to such use, and food-processing surfaces are covered during treatment or thoroughly cleaned before using, or in the case of point-source device treatments, devices must not come into direct contact with food preparation surfaces and must be in a minimum distance of 3 feet from exposed foods. (2) To assure safe use of the insect growth regulator, the label and labeling shall conform to that registered by the U.S. Environmental Protection Agency, and it shall be used in accordance with such label and labeling.