Olopatadine Hydrochloride

Identifikatoren & physikalische Daten

CAS No.	140462-76-6
Summenformel	C21H24ClNO3
Durchschnittliche Molmasse	373,9 g/mol
Monoisotopische Masse	373,14447131 g/mol
SMILES	CN(C)CC/C=C1/c2ccccc2COc2ccc(CC(=O)O)cc21.Cl
InChIKey	HVRLZEKDTUEKQH-NOILCQHBSA-N
PubChem CID	5282402
ChEMBL	CHEMBL1719
ChEBI	CHEBI:31933
EC No.	604-185-4
DTXSID	DTXSID0046486

Polarare Oberfläche (TPSA)	49,8
H-Brücken-Donoren	2
H-Brücken-Akzeptoren	4
Frei drehbare Bindungen	5
Schwere Atome	26
Formalladung	0
Komplexität	488
Human Drugs	FDA approved drugs -> Active ingredientEMA approved medicines: Human medicine

GHS-Einstufung	This chemical does not meet GHS hazard criteria for 4.3% (2 of 47) of reports.DangerH301 (87.2%): Toxic if swallowed [Danger Acute toxicity, oral]P264, P270, P273, P301+P316, P321, P330, P391, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 47 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard Classes and Categories	Acute Tox. 3 (87.2%)
Expositionspfade	Ophthalmic use of olopatadine usually does not produce measurable plasma concentrations.
Toxizitätsübersicht	Olopatadine is a selective histamine H1 antagonist that binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Olopatadine is devoid of effects on alpha-adrenergic, dopamine and muscarinic type 1 and 2 receptors.
Signs and Symptoms	Its side effects may include headaches (7% of occurrence) burning and stinging (5%), dry eye, foreign body sensation, hyperemia, keratitis, lid edema, pruritus, asthenia, cold syndrome, pharyngitis, rhinitis, sinusitis, and taste perversion. [Wikipedia]
Carcinogen Classification	No indication of carcinogenicity to humans (not listed by IARC).