Phenoxybenzaminhydrochlorid
PHENOXYBENZAMINE · PHENOXYBENZAMINE HCL · dibenzyline · 688A · Bensylyt · benzylyt · SKF-688A · dibenylin
Identifikatoren & physikalische Daten
| CAS No. | 63-92-3 |
|---|---|
| Summenformel | C18H22ClNO.ClH |
| Durchschnittliche Molmasse | 340,3 g/mol |
| Monoisotopische Masse | 339,1156697 g/mol |
| SMILES | CC(COc1ccccc1)N(CCCl)Cc1ccccc1.Cl |
| InChIKey | VBCPVIWPDJVHAN-UHFFFAOYSA-N |
| PubChem CID | 5284441 |
| ChEMBL | CHEMBL1200787 |
| ChEBI | CHEBI:8078 |
| EC No. | 200-569-7 |
| DTXSID | DTXSID0021127 |
| Lokaler Name | Phenoxybenzaminhydrochlorid |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 12,5 |
|---|---|
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 8 |
| Schwere Atome | 22 |
| Formalladung | 0 |
| Komplexität | 262 |
| Löslichkeit | less than 0.1 mg/mL at 65.3 °F (NTP, 1992)45.8 [ug/mL] (The mean of the results at pH 7.4)soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).<0.01 g/100 mL at 18.5 ºC |
| Human Drugs | FDA approved drugs -> Active ingredient |
| Schmelzpunkt | 280 to 284 °F (NTP, 1992)137.5°C |
| Physical Description | Phenoxybenzamine hydrochloride is a white crystalline powder. Melting point 137.5-140 °C. Used as an antihypertensive drug. |
| Collision Cross Section | 194.2 Ų [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards] |
| Lagerbedingungen | 15-25°C |
| pKa (Säurekonstante) | pKa 4.4 (Uncertain) |
| Aggregatzustand | powder |
| Farbe | white |
| Merck | 14,7256 |
| Stabilität | Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| InChI | 1S/C18H22ClNO.ClH/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17/h2-11,16H,12-15H2,1H3 |
| InChIKey | VBCPVIWPDJVHAN-UHFFFAOYSA-N |
| SMILES | Cl[H].CC(COc1ccccc1)N(CCCl)Cc2ccccc2 |
| CAS Datenbank | 63-92-3(CAS DataBase Reference) |
| EPA chemische Informationen | N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride (63-92-3) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P203, P264, P270, P280, P301+P317, P318, P330, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 42 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.DangerH350: May cause cancer [Danger Carcinogenicity] |
|---|---|
| Regulatorische Informationen | Hazard Traits - CarcinogenicityBenzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right. |
| Weitere Sicherheitsinformationen | IMAP assessments - Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride: Human health tier I assessment |
| Brandgefahren | Flash point data are not available for this chemical, but it is probably combustible. (NTP, 1992) |
| Gesundheitsgefahren | SYMPTOMS: Symptoms of exposure to this compound include nasal congestion, miosis, postural hypotension, tachycardia, gastrointestinal irritation, drowsiness and fatigue. |
| Reaktive Gruppe | Ethers |
| Air and Water Reactions | Light sensitive and may be sensitive to exposure to air (NTP, 1992). Insoluble in water. |
| Hazard Classes and Categories | Acute Tox. 4 (100%)Acute toxicity (Oral) - Category 5Carcinogenicity - Category 1B |
| Brandbekämpfung | Fires involving this compound should be controlled using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992) |
| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
Anwendungen & Verwendung
Beschreibung
Phenoxybenzamine hydrochloride (dibenzyline) is an orally effective, long-acting non-selective (alpha1 and alpha2) alpha-adrenoceptor blocking agent. It is used for the control of episodes of hypertension associated withpheochromocytoma. It literally produces a "chemical sympathectomy". It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. The initialdose is 10 mg/day, increased by 10 mg every 4 days till the desired response is attained.The usual dosage range is 20-60mg/day.
Verwenden
Phenoxybenzamine (5.0 to 60.0 mg/day) is used in order to control episodes of hypertension and sweating, it has a relatively slow onset and prolonged effect when compared to alternative α-blockers. If tachycardia is excessive, it may also be necessary to use a betablocker concomitantly. In addition, phenoxybenzamine has been tested for its efficacy in micturition disorders resulting from neurogenic bladder, functional outlet obstruction, and partial prostatic obstruction.