Menaquinone 7
Grundinformationen
- CAS
2124-57-4- Standard-SMILES
CC(C)=CCC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC1=C(C)C(=O)c2ccccc2C1=O- InChIKey
RAKQPZMEYJZGPI-LJWNYQGCSA-N- Summenformel
- C46H64O2
- Durchschnittliche Molmasse
- 649 g/mol
- Monoisotopische Masse
- 648,49063128
Überblick
Menaquinone-7 is a menaquinone whose side-chain contains seven isoprene units in an all-trans-configutation. It has a role as a Mycoplasma genitalium metabolite, a cofactor, a bone density conservation agent, an Escherichia coli metabolite and a human blood serum metabolite.
Namen und Bezeichner
- Bevorzugter Name
- Menaquinone 7
- IUPAC
- 2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaenyl]-3-methylnaphthalene-1,4-dione
- Englischer Name
- Menaquinone 7
- Summenformel
- C46H64O2
- Molmasse
- 649
Namen und Synonyme
Menaquinone-7Menaquinone 72124-57-4Vitamin K2(35)Menaquinone K7Vitamin MK 7Menakinon 72-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-Heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalene-1,4-dione8427BML8NY1,4-Naphthalenedione, 2-(3,7,11,15,19,23,27-heptamethyl-2,6,10,14,18,22,26-octacosaheptaenyl)-3-methyl-, (all-E)-2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaenyl]-3-methylnaphthalene-1,4-dione2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl]-3-methylnaphthalene-1,4-dione
Weitere Namen anzeigen
Menlaquinone 7Menaquinone 7, Synthetic (90%)Menaquinone-7(MK-7)Menatetrenone (MK-7)
CHEBI:44245DTXSID8013174742-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaenyl)-3-methylnaphthalene-1,4-dioneRefChem:925473DTXCID90908566Vitamin K2-7MK-7Menaquinone 7, Synthetic
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 14,5
- Polarare Oberfläche (TPSA)
- 34,1 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 20
- Schwere Atome
- 48
- Formalladung
- 0
- Komplexität
- 1.310
Experimentelle und physikochemische Eigenschaften
Chemical ClassesBiological Agents -> Vitamins and Derivatives
DrugsPharmaceuticals -> Listed in ZINC15
LipidsLipids -> Prenol Lipids [PR] -> Quinones and hydroquinones [PR02] -> Vitamin K [PR0203]
Physical DescriptionLight yellow solid; [Merck Index]
Physikochemische Eigenschaften
- Schmelzpunkt
- 54 °C · 54 °C
- Siedepunkt
- 0.0002 · bp0.0002 200° (some dec)
- Dichte
- 0.961 · 0.961
- storage temp.
- -20 °C · -20°C
- Löslichkeit
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- Pale Yellow to Yellow
- Stabilität
- Light and Temperature Sensitive
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 100% (105 of 105) of all reports.
Not Classified
Aggregated GHS information provided per 105 reports by companies from 1 notifications to the ECHA C&L Inventory.
Gefahrenhinweise
Hazard Classes and CategoriesNot Classified
Sicherheitsdaten
- wgk
- WGK 2
- hs_code
- 2936299055
- Speicherklasse
- 3 - Flammable liquids
- Giftige Stoffe Daten
- 2124-57-4(Hazardous Substances Data)
- Hazard Classifications
- Acute Tox. 4 DermalAcute Tox. 4 InhalationAcute Tox. 4 OralEye Irrit. 2Flam. Liq. 2
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure.
Verwendung und Herstellung
UsesMenaquinones (vitamin K2) have vitamin K activity; Produced by intestinal bacteria and used as a vitamin (prothrombogenic); [Merck Index]
Anwendungen
BeschreibungMenaquinone 7 (MK-7) is a vitamin K2 analog that has been found in a variety of fermented foods. It increases osteocalcin, osteoprotegerin, and RANKL mRNA expression in osteoblastic MC3T3E cells. MK-7 (1 μM) increases alkaline phosphatase activity and calcium content in femoral-metaphyseal tissues isolated from normal and skeletal-unloaded rats. In vivo, MK-7 (100 μg/g diet) inhibits aortic and myocardial calcification and decreases aortic alkaline phosphatase tissue concentrations in a rat model of extraosseous calcification. It also increases trabecular number, bone mineral density, and bone mineral content in a rat model of ovariectomy-induced bone loss.
VerwendenVitamin (prothrombogenic)
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
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