Oligomycin A
Grundinformationen
- CAS
579-13-5- Standard-SMILES
CC[C@H]1/C=C/C=C/C[C@@H](C)[C@H](O)[C@@](C)(O)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)/C=C/C(=O)O[C@@H]2[C@H](C)[C@H](CC1)O[C@]1(CC[C@H](C)[C@H](C[C@@H](C)O)O1)[C@H]2C- InChIKey
MNULEGDCPYONBU-AWJDAWNUSA-N- Summenformel
- C45H74O11
- Durchschnittliche Molmasse
- 791,1 g/mol
- Monoisotopische Masse
- 790,52311317
Überblick
Oligomycin A is an oligomycin with formula C45H74011. An inhibitor of mitochondrial F1FO ATP synthase that induces apoptosis in a variety of cell types and exhibits antifungal, antitumour, and nematicidal activities, but its clinical application has been limited by poor solubility in water and other biocompatible solvents. It has a role as a nematicide, an antineoplastic agent and an EC 3.6.3.14 (H(+)-transporting two-sector ATPase) inhibitor. It is an oligomycin, a pentol, a diketone and an antibiotic antifungal agent.
Namen und Bezeichner
- Bevorzugter Name
- Oligomycin A
- IUPAC
- (1R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,27R,28S,29R)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-oxane]-3,9,13-trione
- Lokaler Name
- Oligomycin A
- Englischer Name
- OLIGOMYCIN A
- Summenformel
- C45H74O11
- Molmasse
- 791.06
Namen und Synonyme
oligomycin A579-13-505HQS4AI99MCH 32RP-32705MCH-32CHEBI:28285NSC-717694(1R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,27R,28S,29R)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,9,13-trioneCHEMBL1256136(1R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,27R,28S,29R)-22-ethyl-7,11,14,15-tetrahydroxy-6'-((2R)-2-hydroxypropyl)-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-3H,9H,13H-spiro(2,26-dioxabicyclo(23.3.1)nonacosa-4,18,20-triene-27,2'-pyran)-3,9,13-trioneRefChem:53391
Weitere Namen anzeigen
OLIGOMYCIN COMPLEXCS-1898Olimycin AAOligoMyciOligomycin A, >=98%Oligomycin A MCH 32OLIGOMYCIN A USP/EP/BP
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 7,1
- Polarare Oberfläche (TPSA)
- 180 Ų
- H-Brücken-Donoren
- 5
- H-Brücken-Akzeptoren
- 11
- Frei drehbare Bindungen
- 3
- Schwere Atome
- 56
- Formalladung
- 0
- Komplexität
- 1.390
Physikochemische Eigenschaften
- Schmelzpunkt
- 150 · 150-151℃
- Siedepunkt
- 886.3 · 886.3±65.0 °C(Predicted)
- Dichte
- 1.14 · 1.14
- storage temp.
- -20 °C · Sealed in dry,Store in freezer, under -20°C
- Löslichkeit
- Soluble in DMSO, ethanol or acetone
- pka
- 12.52 · 12.52±0.70(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to off-white
- Merck
- 13 · 13,6902
- BRN
- 5702132 · 5702132
- InChIKey
- MNULEGDCPYONBU-WMBHJXFZSA-N
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 67 reports by companies from 1 notifications to the ECHA C&L Inventory.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Sicherheitsdaten
- F
- 3-10
- wgk
- 3
- ridadr
- 2811
- hs_code
- 29419090
- RTECS-Nr.
- RK3325000
- risk_code
- 22-68/20/21/22-20/21/22
- hazard_code
- Xn,T
- safety_code
- 36/37-24/25
- hazard_class
- 6.1(b)
- packing_group
- III
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Anwendungen
BeschreibungOligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin A, a dominant analog of the isomers, is an inhibitor of mitochondrial F1FO ATP synthase that induces apoptosis in a variety of cell types (average GI50 = 270 nM). Oligomycin A exhibits antifungal, antitumor, and nematocidal activities, but has poor solubility in water and other biocompatible solvents, which limits its clinical application.
VerwendenOligomycin A is a macrolide with fungicidal activity isolated from Streptomyces species.
Anbieter100 Anbieter
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]
上海哲研生物科技有限公司021-18017610038 18017610038 · [email protected]
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
Zugehörige Reaktionen
0
Keine Reaktionsaufzeichnungen unter den aktuellen Filterkriterien.
Notizen zur Verbindung
Wird geladen…