C5a Receptor Antagonist, W-54011
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Grundinformationen
- CAS
405098-33-1- Standard-SMILES
COc1ccc2c(c1)C(C(=O)N(Cc1ccc(N(C)C)cc1)c1ccc(C(C)C)cc1)CCC2.Cl- InChIKey
UKBJWRMNGCDKNL-UHFFFAOYSA-N- Summenformel
- C30H37ClN2O2
- Durchschnittliche Molmasse
- 493,091 g/mol
- Monoisotopische Masse
- 492,2543561
Namen und Bezeichner
- Bevorzugter Name
- C5a Receptor Antagonist, W-54011
- IUPAC
- N-{[4-(Dimethylamino)phenyl]methyl}-7-methoxy-N-[4-(propan-2-yl)phenyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide--hydrogen chloride (1/1)
- Englischer Name
- N-[[4-(Dimethylamino)phenyl]methyl]-1,2,3,4-tetrahydro-7-methoxy-N-[4-(1-methylethyl)phenyl]-1-naphthalenecarboxamide hydrochloride
- Summenformel
- C30H36N2O2.ClH
- Molmasse
- 493.08
Namen und Synonyme
W-54011CS-2062W-54011, 10 mM in DMSOC5a Receptor Antagonist, W-54011N-{[4-(diMethylaMino)phenyl]Methyl}-7-Methoxy-N-[4-(propan-2-yl)phenyl]-1,2,3,4-tetrahydronaphthalene-1-carboxaMide hydrochlorideN-[[4-(Dimethylamino)phenyl]methyl]-1,2,3,4-tetrahydro-7-methoxy-N-[4-(1-methylethyl)phenyl]-1-naphthalenecarboxamide hydrochloridechemotaxis,inhibit,orally,W-54011,mobilization,anaphylatoxin,ROS,Reactive Oxygen Species,Ca2+,C5a,neutrophils,Inhibitor,Complement System,W54011,inflammatory,W 54011
Datenbank-Bezeichner
- CAS
405098-33-1- PubChem CID
- 5311121
- DTXSID
DTXSID50415509- ChEMBL
CHEMBL5092226- ChEBI
CHEBI:197423
Eigenschaften
Physikochemische Eigenschaften
- storage temp.
- -20 °C · Store at -20°C
- Löslichkeit
- 30 mg/mL; · DMF: 30 mg/mL; DMSO: 30 mg/mL; Ethanol: 3 mg/mL
- Aggregatzustand
- White powder solid.
- Farbe
- White to light yellow
- Stabilität
- Hygroscopic
Chemie und Industrie
Anwendungen
BeschreibungW-54011 is an orally bioavailable, nonpeptide antagonist of complement component 5a receptor 1 (C5aR), also known as cluster of differentiation 88 (CD88). W-54011 inhibits 125I-rhC5a binding in neutrophils (Ki = 2.2 nM) and C5a-mediated intracellular Ca2+ mobilization (IC50 = 3.1 nM). W-54011 is selective and does not affect Ca2+ mobilization mediated by other G protein-coupled receptor (GPCR) ligands, N-Formyl-Met-Leu-Phe (fMLF; ), or IL-8 up to a concentration of 10 μM. It inhibits Ca2+ mobilization in neutrophils in humans, cynomolgus monkeys, and gerbils, but not in mice, rats, guinea pigs, rabbits, or dogs. At 10 nM, W-54011 also inhibits C5a-mediated migration and vessel formation of human microvascular endothelial cells (HMEC-1).
VerwendenW 54011 is a potent orally active non-peptide C5a receptor antagonist.
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上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
欧利希（湖北）医药科技有限公司17316404525 17316404525 · [email protected]
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MedBio脉铂医药021-69568360 18916172912 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
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