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HCID 5320Erstellt: 26. Oktober 2026

Sulfacetamid

A-500 · Region · Oclucid · Sebizon · Albucid · Alesten · Sulamyd · Sulf-10

https://huagongshe.com/de/chemical/5320

Molekülstruktur von Sulfacetamid

Identifikatoren & physikalische Daten

CAS No.144-80-9
SummenformelC8H10N2O3S
Durchschnittliche Molmasse214,24 g/mol
Monoisotopische Masse214,04121318 g/mol
SMILESCC(=O)NS(=O)(=O)c1ccc(N)cc1
InChIKeySKIVFJLNDNKQPD-UHFFFAOYSA-N
PubChem CID5320
ChEMBLCHEMBL455
ChEBICHEBI:63845
EC No.205-640-6
DTXSIDDTXSID8026060
Lokaler NameSulfacetamid

Chemische & physikalische Eigenschaften

XLogP-1
Polarare Oberfläche (TPSA)97,6
H-Brücken-Donoren2
H-Brücken-Akzeptoren4
Frei drehbare Bindungen2
Schwere Atome14
Formalladung0
Komplexität299
ArzneimittelPharmaceuticals -> AntibioticsPharmaceuticals -> Listed in ZINC15
SpringerMaterials PropertiesNuclear quadrupole resonance spectroscopy
LogP (Verteilungskoeffizient)-0.6-0.1
Löslichkeitless than 0.1 mg/mL at 61 °F (NTP, 1992)4.21e+00 g/L>32.1 [ug/mL] (The mean of the results at pH 7.4)ethanol: soluble50mg/mL<0.01 g/100 mL at 16 ºC
Human DrugsFDA approved drugs -> Active ingredient
Animal DrugsPharmaceuticals -> Animal Drugs -> Approved in Taiwan
Schmelzpunkt360 to 363 °F (NTP, 1992)183 °C182-184 °C
Physical DescriptionSulfacetamide is a white powder. (NTP, 1992)Solid
Collision Cross Section154.8 Ų [M+Na]+ [CCS Type: DTBuffer gas: N2Ionization: ESI+Dataset: TOXCASTSource Identifier: DTXSID8026060]141.79 Ų [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards]146.9 Ų [M+H]+ [CCS Type: TW152.76 Ų [M+Na]+
Dichte1.3844 (rough estimate)
Brechungsindex1.5690 (estimate)
LagerbedingungenKeep in dark place,Inert atmosphere,Room temperature
pKa (Säurekonstante)pKa 1.76±0.04(H2O t = 25 I = 0.15 (KCl) Ar atmosphere)(Approximate)5.22±0.01(H2O t = 25 I = 0.15 (KCl) Ar atmosphere)(Approximate)
Aggregatzustandpowder
Farbewhite to off-white
Merck14,8899
BRN981718
StabilitätStable. Incompatible with strong oxidizing agents, strong bases, strong reducing agents, strong acids.
Hauptanwendungenclinical testing
InChI1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)
InChIKeySKIVFJLNDNKQPD-UHFFFAOYSA-N
SMILESCC(=O)NS(=O)(=O)c1ccc(N)cc1
CAS Datenbank144-80-9(CAS DataBase Reference)
NIST chemische InformationenN-(p-Aminobenzenesulfonyl)acetamide(144-80-9)
EPA chemische InformationenSulfacetamide (144-80-9)

Sicherheit & Vorschriften

GHS-EinstufungThis chemical does not meet GHS hazard criteria for 10% (4 of 40) of reports.WarningH317 (77.5%): May cause an allergic skin reaction [Warning Sensitization, Skin]P203, P261, P271, P272, P280, P302+P352, P304+P340, P318, P319, P321, P333+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 40 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Regulatorische InformationenStatus: Active Update: 09-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/25894
Weitere SicherheitsinformationenIMAP assessments - Acetamide, N-[(4-aminophenyl)sulfonyl]-: Environment tier I assessment
BrandgefahrenFlash point data for this chemical are not available. It is probably combustible. (NTP, 1992)
Reaktive GruppeAmides and Imides
Reactivity ProfileSULFACETAMIDE is an amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generate mixed oxides of nitrogen (NOx)
Air and Water ReactionsInsoluble in water.
Hazard Classes and CategoriesSkin Sens. 1 (77.5%)
BrandbekämpfungFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
Erste HilfeEYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
Freisetung ohne BrandSMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Personal Protective Equipment (PPE)RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)
Wassergefährdungsklasse (WGK)2
TSCA-Inventar-StatusTSCA listed
Zollcode29350090
RTECS-Nr.AC8450000
R-Sätze (R)20/21/22-36/37/38
ToxizitätLD50 orally in dogs: 8000 mg/kg (Fisher)
GefahrensymboleXi
Sicherheitshinweise (S)22-24/25-36-26
Lagerklasse11 - Combustible Solids
GefahrenklasseSkin Sens. 1STOT SE 3