Mivavotinib
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Grundinformationen
- CAS
1312691-33-0- Standard-SMILES
Cn1cc(-c2nc(N[C@@H]3CCCC[C@@H]3N)c(F)c3c2C(=O)NC3)cn1- InChIKey
MJHOMTRKVMKCNE-NWDGAFQWSA-N- Summenformel
- C17H21FN6O
- Durchschnittliche Molmasse
- 344,4 g/mol
Überblick
Mivavotinib is an inhibitor of spleen tyrosine kinase (syk), with potential anti-inflammatory, immunomodulating, and antineoplastic activities. Upon administration, mivavotinib may inhibit the activity of syk, which abrogates downstream B-cell receptor (BCR) signaling and leads to an inhibition of B-cell activation, chemotaxis, adhesion and proliferation. Syk, a BCR-associated non-receptor tyrosine kinase that mediates diverse cellular responses, including proliferation, differentiation, and phagocytosis, is expressed in hematopoietic tissues and is often overexpressed in hematopoietic malignancies.
Namen und Bezeichner
- Bevorzugter Name
- Mivavotinib
- IUPAC
- 6-[[(1R,2S)-2-aminocyclohexyl]amino]-7-fluoro-4-(1-methylpyrazol-4-yl)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one
- Englischer Name
- TAK-659
- Summenformel
- C17H21FN6O
- Molmasse
- 344.39
Namen und Synonyme
Mivavotinib1312691-33-0TAK-659 free baseTAK-659F8QR88H79VXCB-6596-[[(1R,2S)-2-aminocyclohexyl]amino]-7-fluoro-4-(1-methylpyrazol-4-yl)-1,2-dihydropyrrolo[3,4-c]pyridin-3-oneTAK6593H-Pyrrolo[3,4-c]pyridin-3-one, 6-[[(1R,2S)-2-aminocyclohexyl]amino]-7-fluoro-1,2-dihydro-4-(1-methyl-1H-pyrazol-4-yl)-3H-Pyrrolo(3,4-C)pyridin-3-one, 6-(((1R,2S)-2-aminocyclohexyl)amino)-7-fluoro-1,2-dihydro-4-(1-methyl-1H-pyrazol-4-yl)-mivavotinibum6-(((1R,2S)-2-aminocyclohexyl)amino)-7-fluoro-4-(1-methylpyrazol-4-yl)-1,2-dihydropyrrolo(3,4-c)pyridin-3-one
Weitere Namen anzeigen
TAK-659-01TAK 659TAK-659 free base(Mivavotinib)6-((1R,2S)-2-Aminocyclohexylamino)-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,4-c]pyridin-3(2H)-one
TAK659 Free Basesyk Inhibitor TAK659syk-Inhibitor TAK659syk Inhibitor TAK-659syk-Inhibitor TAK-659RefChem:1089763Spleen Tyrosine Kinase Inhibitor TAK659TAK-659
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- XLogP
- 0,5
- Polarare Oberfläche (TPSA)
- 97,9 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 6
- Frei drehbare Bindungen
- 3
- Schwere Atome
- 25
- Formalladung
- 0
- Komplexität
- 508
Physikochemische Eigenschaften
- Siedepunkt
- 661.7 · 661.7±55.0 °C(Predicted)
- Dichte
- 1.58 · 1.58±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- Löslichkeit
- Soluble in DMSO
- pka
- 10.9 · 10.90±0.20(Predicted)
Chemie und Industrie
Anbieter4 Anbieter
InvivoChem中国13549236410 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
InvivoChem+1-708-310-1919 +1-13798911105 · [email protected]
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