Sulfamethoxazol

Sulfamethoxazole

HCID 5329CAS 144930-01-8

Grundinformationen

Standard-SMILES
Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1
InChIKey
JLKIGFTWXXRPMT-UHFFFAOYSA-N
Summenformel
C10H11N3O3S
Durchschnittliche Molmasse
253,28 g/mol
Monoisotopische Masse
253,05211239

Namen und Bezeichner

Bevorzugter Name
Sulfamethoxazole
IUPAC
4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide
Lokaler Name
Sulfamethoxazol
Englischer Name
Sulfamethoxazole
Summenformel
C10H11N3O3S
Molmasse
253.28

Namen und Synonyme

sulfamethoxazole723-46-6GantanolSulphamethoxazoleSulfisomezoleSulfamethoxazol4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamideRadonilSinominSulfamethylisoxazole4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamideSulfamethalazole
Weitere Namen anzeigen
SMXSMZCo-trimoxazoleBactrimSeptraN1-(5-METHYLISOXAZOL-3-YL)SULFANILAMIDETribSeptrin
Azo-gantanolUrobakSulfamethoxizoleGantanol-DSRo 4-2130SulfametoxazolGamazole3-Sulfanilamido-5-methylisoxazole

Datenbank-Bezeichner

CAS
144930-01-8、144993-89-5、723-46-6
PubChem CID
5329
DTXSID
DTXSID8026064
ChEMBL
CHEMBL443
ChEBI
CHEBI:9332
UNII
JE42381TNV
EC Number
211-963-3、656-929-2
Nikkaji
J4.525J

Eigenschaften

Berechnete Struktureigenschaften

XLogP
0,9
Polarare Oberfläche (TPSA)
107 Ų
H-Brücken-Donoren
2
H-Brücken-Akzeptoren
6
Frei drehbare Bindungen
3
Schwere Atome
17

Physikochemische Eigenschaften

Schmelzpunkt
166 °C · 166 °C
Siedepunkt
482 ℃ · 482℃
Dichte
1.3915 · 1.3915 (rough estimate)
Brechungsindex
1.663 · 1.6630 (estimate)
Flammpunkt
110 ° · >110°(230°F)
storage temp.
Keep in dark place,Inert atmosphere,Room temperature

Sicherheit und Regulatorisches

Sicherheitsdaten

wgk
2
tsca
TSCA listed
hs_code
29350090
RTECS-Nr.
WP0700000
risk_code
36/37/38-43-22
Toxizität
LD50 orally in mice: 3662 mg/kg (Yamamoto)

Chemie und Industrie

Anwendungen · 1 Eintrag

BeschreibungLike sulfisoxazole, this drug is effective in treating infections caused by streptococci, gonococci, pneumococci, staphylococci as well as colon bacillus. Unlike sulfisoxazole, only about 70% of it binds with proteins in the plasma after oral administration, and it diffuses mostly to tissues and tissue fluids. However, since it is removed much slower than sulfisoxazole, it does not require frequent administration and is also the drug of choice for many systemic infections. Moreover, it is an ingredient of a combined drug named bactrim, biseptol, and so on (which will be examined later on), which has a fixed correlation with trimethoprim. Synonyms of this drug are gantanol, sinomin, sulfisomezole, and others.

Anbieter50 Anbieter

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

Ergänzende Hinweise

DefinitionChEBI: An isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position.

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3

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