Talipexole
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Grundinformationen
- CAS
101626-70-4- Standard-SMILES
C=CCN1CCc2nc(N)sc2CC1- InChIKey
DHSSDEDRBUKTQY-UHFFFAOYSA-N- Summenformel
- C10H15N3S
- Durchschnittliche Molmasse
- 209,318 g/mol
- Monoisotopische Masse
- 209,09866848
Namen und Bezeichner
- Bevorzugter Name
- Talipexole
- IUPAC
- 6-(Prop-2-en-1-yl)-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepin-2-amine
- Englischer Name
- TALIPEXOLE
- Summenformel
- C10H15N3S
- Molmasse
- 209.31
Namen und Synonyme
DominTalipexolTALIPEXOLETalipexolumTalipexolum [latin]Talipexol [spanish]TALIPEXOLE USP/EP/BP6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine6-Allyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepin-2-amine
Datenbank-Bezeichner
- CAS
101626-70-4- PubChem CID
- 5374
- DTXSID
DTXSID8046321- ChEMBL
CHEMBL279085- ChEBI
CHEBI:93327- UNII
- 7AM2J46Z1Y
- Nikkaji
- J33.385I
Eigenschaften
Physikochemische Eigenschaften
- Siedepunkt
- 364.6 · 364.6±37.0 °C(Predicted)
- Dichte
- 1.167 · 1.167±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- Löslichkeit
- Soluble in DMSO
- Aggregatzustand
- Powder
- pka
- 7.22 · 7.22±0.20(Predicted)
Chemie und Industrie
Anwendungen
BeschreibungDomin was launched in Japan for Parkinson's disease. The compound is readily accessible in two steps from I-allylhexahydro-4H-azepin4-one. Its antiparkinson activity resides in the fact that talipexole is a selective agonist for presynaptic dopamine D2 receptors with no D1 receptor activity. It is a clonidine-like α2-adrenoreptor agonist and has fewer GI side effects than bromocriptine the most widely used dopamine angonist. Also it is 70 times more potent than bromocriptine and has a more rapid onset of action. In addition to its anti-tremor activity there was a sedative effect but no emesis. The latter probably a result of talipexole's 5-HT3 receptor antagonistic activity. Its metabolites have no biological activity, there was no development of tolerence and its effect could be enhanced by L-dopa.
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Anbieter19 Anbieter
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
陕西缔都化学有限公司029-029-81123119 17391733320 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
河南阿尔法化工有限公司0371-55013243 15324716602 · [email protected]
MedChemexpress LLC021-58955995 · [email protected]
天津普西唐生物医药科技有限公司
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