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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HCID 5375083Erstellt: 4. November 2026

Fusarium toxin

(E)-3,4,5,6,9,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione

https://huagongshe.com/de/chemical/5375083

Molekülstruktur von Fusarium toxin

Identifikatoren & physikalische Daten

CAS No.17924-92-4
SummenformelC18H22O5
Durchschnittliche Molmasse318,4 g/mol
Monoisotopische Masse318,1467238 g/mol
SMILESCC1CCCC(=O)CCC/C=C/c2cc(O)cc(O)c2C(=O)O1
InChIKeyMBMQEIFVQACCCH-CLTKARDFSA-N
PubChem CID5375083
ChEMBLCHEMBL1397216
ChEBICHEBI:175078

Chemische & physikalische Eigenschaften

XLogP3,6
Polarare Oberfläche (TPSA)83,8
H-Brücken-Donoren2
H-Brücken-Akzeptoren5
Frei drehbare Bindungen0
Schwere Atome23
Formalladung0
Komplexität445
Schmelzpunkt164 - 165 °C
Physical DescriptionSolid

Sicherheit & Vorschriften

Gesundheitliche AuswirkungenZearalenone is a reproductive toxin and has been shown to cause infertility, abortion or other breeding problems in livestock. In humans it can cause earlier onset of puberty in children, endometrial adenocarcinomas, hyperplasia, and breast cancer in women. Zearalenone is also immunotoxic, genotoxic, and can cause kidney and liver damage. (L1947, A2960)
ExpositionspfadeOral, dermal, inhalation, and parenteral (contaminated drugs). (A3101)
ToxizitätsübersichtZearalenone's genotoxicity results from it's ability to cause DNA fragmentation, chromosome aberrations, and DNA adduct formation. It exerts cytotoxic effects by enhancing lipid peroxidation, increasing oxidative stress, and inducing apoptosis. Zearalenone also has significant estrogenic activity, causing severe reproductive problems in animals. In humans, Zearalenone has been shown to cause an earlier onset of puberty in children, endometrial adenocarcinomas, hyperplasia and breast cancer in women. Mycotoxins are often able to enter the liver and kidney by human organic anion transporters (hOATs) and human organic cation transporters (hOCTs). They can also inhibit uptake of anions and cations by these transporters, interefering with the secretion of endogenous metabolites, drugs, and xenobiotics including themselves. This results in increased cellular accumulation of toxic compounds causing nephro- and hepatotoxicity. (A2960, A3014)
Carcinogen Classification3, not classifiable as to its carcinogenicity to humans. (L135)
Toxicity DataLD50: >2000 mg/kg (Oral, Mouse) (L1912) LD50: >500 mg/kg (Intraperitoneal, Mouse) (L1912)