Tazarotene

Avage · Zorac · Tazorac · agn190168 · azarotene · TAZAROTENE · Tazorac/zorac · Tazarotene(Avage)

Identifikatoren & physikalische Daten

CAS No.	118292-40-3
Summenformel	C21H21NO2S
Durchschnittliche Molmasse	351,5 g/mol
Monoisotopische Masse	351,12929991 g/mol
SMILES	CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(C)(C)CCS3)nc1
InChIKey	OGQICQVSFDPSEI-UHFFFAOYSA-N
PubChem CID	5381
ChEMBL	CHEMBL1657
ChEBI	CHEBI:32184
DTXSID	DTXSID5046691

Chemische & physikalische Eigenschaften

XLogP	4,9
Polarare Oberfläche (TPSA)	64,5
H-Brücken-Donoren	0
H-Brücken-Akzeptoren	4
Frei drehbare Bindungen	5
Schwere Atome	25
Formalladung	0
Komplexität	547
Arzneimittel	Pharmaceuticals -> Listed in ZINC15
LogP (Verteilungskoeffizient)	5.6
Löslichkeit	Soluble7.50e-04 g/LDMSO: >15mg/mL
Human Drugs	Breast FeedingLactationMilk, HumanDermatologic AgentsKeratolytic AgentsFDA approved drugs -> Active ingredient
Physical Description	Solid
Schmelzpunkt	95-98°C
Siedepunkt	499.8±45.0 °C(Predicted)
Dichte	1.22±0.1 g/cm3(Predicted)
Lagerbedingungen	2-8°C
pKa (Säurekonstante)	0.04±0.29(Predicted)
Aggregatzustand	powder
Farbe	white to very faintly yellow
Merck	14,9081
Kosmetik-Inhaltsstoffe Funktionen	SKIN CONDITIONING
InChI	InChI=1S/C21H21NO2S/c1-4-24-20(23)16-7-9-17(22-14-16)8-5-15-6-10-19-18(13-15)21(2,3)11-12-25-19/h6-7,9-10,13-14H,4,11-12H2,1-3H3
InChIKey	OGQICQVSFDPSEI-UHFFFAOYSA-N
SMILES	C1=NC(C#CC2C=C3C(=CC=2)SCCC3(C)C)=CC=C1C(OCC)=O
CAS Datenbank	118292-40-3(CAS DataBase Reference)

Sicherheit & Vorschriften

Effects During Pregnancy and Lactation	◉ Summary of Use during Lactation
Wassergefährdungsklasse (WGK)	3
Zollcode	2934.99.3000
RTECS-Nr.	US5675100
Lagerklasse	11 - Combustible Solids
Gefahrenklasse	Repr. 2

Anwendungen & Verwendung

Verwenden

Tazarotene is a prescription topical retinoid sold as a cream or gel. This medication is approved for treatment of psoriasis, acne, and sun damaged skin (photodamage). It is commonly sold in two concentrations: 0.05% and 0.1%. In addition to tretinoin, wh