Temazepam

er115 · k3917 · wy3917 · wy2917 · Planum · ER 115 · K-3917 · Wy-3917

Identifikatoren & physikalische Daten

CAS No.	846-50-4
Summenformel	C16H13ClN2O2
Durchschnittliche Molmasse	300,74 g/mol
Monoisotopische Masse	300,06655534 g/mol
SMILES	CN1C(=O)C(O)N=C(c2ccccc2)c2cc(Cl)ccc21
InChIKey	SEQDDYPDSLOBDC-UHFFFAOYSA-N
PubChem CID	5391
ChEMBL	CHEMBL967
ChEBI	CHEBI:9435
EC No.	212-688-1
DTXSID	DTXSID8021309
Lokaler Name	Temazepam

Chemische & physikalische Eigenschaften

XLogP	2,2
Polarare Oberfläche (TPSA)	52,9
H-Brücken-Donoren	1
H-Brücken-Akzeptoren	3
Frei drehbare Bindungen	1
Schwere Atome	21
Formalladung	0
Komplexität	434
Stoffklassen	Pharmaceutical
Arzneimittel	DEA NFLIS-Drug Category -> BenzodiazepinesDEA Schedule IV Controlled Substance -> DepressantsPharmaceuticalsPharmaceuticals -> HypnoticPharmaceuticals -> Synthetic Cannabinoids or Psychoactive Compounds
LogP (Verteilungskoeffizient)	3
Löslichkeit	5.34e-02 g/LPractically insoluble in water, freely soluble in methylene chloride, sparingly soluble in ethanol (96 per cent).
Human Drugs	Breast FeedingLactationMilk, HumanHypnotics and SedativesAnti-Anxiety AgentsBenzodiazepinesFDA approved drugs -> Active ingredientPharmaceuticals
Schmelzpunkt	119-121 °C119 - 121 °C119-121°C
Physical Description	Solid
Collision Cross Section	166.1 Å² [M+H]+ [CCS Type: TWMethod: Major Mix IMS/Tof Calibration Kit (Waters)]
Siedepunkt	211°C (rough estimate)
Dichte	1.2682 (rough estimate)
Brechungsindex	1.5200 (estimate)
Flammpunkt	11 °C
Lagerbedingungen	2-8°C
pKa (Säurekonstante)	pKa 1.6 (Uncertain)
BCS Class	2
CAS Datenbank	846-50-4(CAS DataBase Reference)
EPA chemische Informationen	Temazepam (846-50-4)

Sicherheit & Vorschriften

GHS-Einstufung	WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 52 reports by companies from 7 notifications to the ECHA C&L Inventory.
Regulatorische Informationen	Hazard Traits - Developmental ToxicityDEA schedule IV controlled substanceTemazepam: Does not have an individual approval but may be used under an appropriate group standard
Weitere Sicherheitsinformationen	IMAP assessments - 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-: Environment tier I assessment
Hazard Classes and Categories	Acute Tox. 4 (100%)
Treatment	If the patient is conscious, vomiting should be induced mechanically or with emetics. Gastric lavage should be employed utilizing concurrently a cuffed endotracheal tube if the patient is unconscious to prevent aspiration and pulmonary complications. Maintenance of adequate pulmonary ventilation is essential. The use of pressor agents intravenously may be necessary to combat hypotension. Fluids should be administered intravenously to encourage diuresis. (L1712)
Gesundheitliche Auswirkungen	They cause slurred speech, disorientation and "drunken" behavior. They are physically and psychologically addictive.
Hepatotoxicity	Temazepam, like other benzodiazepines, is rarely associated with serum ALT elevations, and clinically apparent liver injury from temazepam is extremely rare, if it occurs at all. There have been no case reports of symptomatic, acute liver injury from temazepam. Isolated single cases of clinically apparent liver injury have been reported with other benzodiazepines including alprazolam, chlordiazepoxide, clonazepam, diazepam, flurazepam, lorazepam, and triazolam. The clinical pattern of acute liver injury from benzodiazepines is typically cholestatic and mild-to-moderate in severity with a latency of 1 to 6 months and rapid resolution with discontinuation. Fever and rash are uncommon as is autoantibody formation.
Unerwünschte Wirkungen	Adverse Drug Reactions

Anwendungen & Verwendung

Verwenden

Temazepam, is pharmacologically active metabolite of Diazepam (D416855). It is Sedative, and hypnotic. Controlled substance (depressant).