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Terconazol
Terazol 3 · Triaconazole · R42470 · Fungistat · Terazol 7 · TERCONAZOLE · Terconagole · Gyno-Terazol
Identifikatoren & physikalische Daten
| CAS No. | 67915-31-5 |
|---|---|
| Summenformel | C26H31Cl2N5O3 |
| Durchschnittliche Molmasse | 532,5 g/mol |
| Monoisotopische Masse | 531,1803953 g/mol |
| SMILES | CC(C)N1CCN(c2ccc(OCC3COC(Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 |
| InChIKey | BLSQLHNBWJLIBQ-UHFFFAOYSA-N |
| PubChem CID | 5404 |
| ChEMBL | CHEMBL1714574 |
| ChEBI | CHEBI:82979 |
| Lokaler Name | Terconazol |
Chemische & physikalische Eigenschaften
| XLogP | 4,8 |
|---|---|
| Polarare Oberfläche (TPSA) | 64,9 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 7 |
| Frei drehbare Bindungen | 8 |
| Schwere Atome | 36 |
| Formalladung | 0 |
| Komplexität | 692 |
| Schmelzpunkt | 126.3°C |
| Siedepunkt | 681.8±65.0 °C(Predicted) |
| Dichte | 1.35±0.1 g/cm3(Predicted) |
| Lagerbedingungen | Inert atmosphere,Room Temperature |
| Löslichkeit | DMSO: soluble1mg/mL |
| pKa (Säurekonstante) | 8.33±0.10(Predicted) |
| Aggregatzustand | powder |
| Farbe | white |
| Hauptanwendungen | forensics and toxicologyveterinary |
| InChIKey | BLSQLHNBWJLIBQ-GRHWAJSLNA-N |
| SMILES | N1(C2=CC=C(OC[C@H]3CO[C@@](C4=CC=C(Cl)C=C4Cl)(CN4C=NC=N4)O3)C=C2)CCN(C(C)C)CC1 |&1:7,10,r| |
| CAS Datenbank | 67915-31-5(CAS DataBase Reference) |
Sicherheit & Vorschriften
| Wassergefährdungsklasse (WGK) | 3 |
|---|---|
| Zollcode | 2934990002 |
| RTECS-Nr. | TL3564600 |
| R-Sätze (R) | 36/37/38-53 |
| Gefahrensymbole | Xi |
| Sicherheitshinweise (S) | 26 |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrenklasse | Aquatic Chronic 4Eye Irrit. 2Skin Irrit. 2STOT SE 3 |
Anwendungen & Verwendung
Beschreibung
Terconazole is an antifungal agent somewhat more potent than clotrimazole and useful in the topical treatment of vaginal dermatophytosis and candidiasis.
Verwenden
Terconazole belongs to a new chemical class of antifungal agents, the triazoles. Terconazole has a far greater selectively for yeast cytochrome P-450 than for mammalian microsomal cytochrome P-450 and is used as topical treatment of mycotic vaginitis. Terconazole may also be used in vitro as a potent antifungal agent to prevent the morphogenetic transformation of yeast into (pseudo-)mycelium form of Candida albicans.