21,23-Dioxa(13)cytochalasa-13,19-dien-1,17,22-trion, 6,7-epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-,(7S,13E,16S,18R,19E)-
Cytochalasin E
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Grundinformationen
- CAS
36011-19-5- Standard-SMILES
C[C@H]1C/C=C/[C@H]2[C@@H]3O[C@]3(C)[C@@H](C)[C@H]3[C@H](Cc4ccccc4)NC(=O)[C@]32OC(=O)O/C=C/[C@@](C)(O)C1=O- InChIKey
LAJXCUNOQSHRJO-ZYGJITOWSA-N- Summenformel
- C28H33NO7
- Durchschnittliche Molmasse
- 495,572 g/mol
- Monoisotopische Masse
- 495,2257024
Namen und Bezeichner
- Bevorzugter Name
- Cytochalasin E
- IUPAC
- (1E,4S,6R,7E,11aS,14S,14aS,15S,15aR,16aS,16bS)-14-Benzyl-6-hydroxy-4,6,15,15a-tetramethyl-3,13,14,14a,15,15a,16a,16b-octahydro-10H-[1,3]dioxacyclotridecino[4,5-d]oxireno[f]isoindole-5,10,12(4H,6H)-trione
- Lokaler Name
- 21,23-Dioxa(13)cytochalasa-13,19-dien-1,17,22-trion, 6,7-epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-,(7S,13E,16S,18R,19E)-
- Englischer Name
- CYTOCHALASIN E
- Summenformel
- C28H33NO7
- Molmasse
- 495.56
Namen und Synonyme
CYTOCHALACINECYTOCHALICINECYTOCHALASIN ECYTOCHALASIN 3CYTOCHALASIN E(RG)CYTOCHALASIN E USP/EP/BPLAJXCUNOQSHRJO-DXUWGLIISA-NCYTOCHALASIN E(RG) Please CallCYTOCHALASIN E, ASPERGILLUS CLAVATUSCYTOCHALASIN E FROM ASPERGILLUSCLAVATUS
Datenbank-Bezeichner
- CAS
36011-19-5- PubChem CID
- 5458385
- DTXSID
DTXSID60894866- ChEMBL
CHEMBL494856- ChEBI
CHEBI:68201- EC Number
- 252-835-7
- Nikkaji
- J4.093B
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 206 °C · 206 °C
- Siedepunkt
- 587.59 °C · 587.59°C (rough estimate)
- Dichte
- 1.2415 · 1.2415 (rough estimate)
- Brechungsindex
- 1.629 · 1.6290 (estimate)
- storage temp.
- -20 °C · -20°C
- Löslichkeit
- 11 mg/ml; · DMF: 11 mg/ml; DMF:PBS (pH7.2) (1:30): 0.03 mg/ml; DMSO: 10 mg/ml; Ethanol: 2 mg/ml
- Aggregatzustand
- White solid.
- pka
- 11.22 · 11.22±0.70(Predicted)
- Farbe
- White to off-white
- BRN
- 1096975 · 1096975
- InChIKey
- LAJXCUNOQSHRJO-ZYGJITOWSA-N
- SMILES
- C[C@H]1C\C=C\[C@H]2[C@@H]3O[C@]3(C)[C@@H](C)[C@H]4[C@H](Cc5ccccc5)NC(=O)[C@@]24OC(=O)O\C=C\[C@@](C)(O)C1=O
- LogP
- 1.92 · 1.920 (est)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- F
- 10
- wgk
- 3
- ridadr
- UN 1544 6.1/PG 2
- hs_code
- 29349990
- RTECS-Nr.
- HA5360000
- risk_code
- 26/27/28-63
- hazard_code
- T+,T
- safety_code
- 28-36/37-45
- hazard_class
- 6.1(a)
- packing_group
- I
- Speicherklasse
- 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
- Giftige Stoffe Daten
- 36011-19-5(Hazardous Substances Data)
- Hazard Classifications
- Acute Tox. 1 InhalationAcute Tox. 2 DermalAcute Tox. 2 OralRepr. 2
Chemie und Industrie
Anwendungen
BeschreibungThe cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin E is an epoxide-containing analog of cytochalasin B which potently and selectively inhibits the growth of endothelial cells (IC50 1 protease activity.
VerwendenCytochalasin E is one of a family of potent mycotoxins produced by a range of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, resulting in pronounced morphogenic changes in animals and plants. Despite the common mode of action, there is evidence that individual members display diverse selectivity. Specifically, cytochalasin E acts as an angiogenesis inhibitor and, unlike other cytochalasins, does not inhibit glucose transport.
Anbieter38 Anbieter
阿诺西（上海）生物技术有限公司400-1107768 15058188853 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
上海赛可锐生物科技有限公司021-58000709 13120558703 · [email protected]
大连美仑生物技术有限公司0411-62910999 13889544652 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
孟成科技（上海）有限公司400-820-6829 · [email protected]
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