Guanidiniumchlorid
GUANIDINE HCL · GUANIDINIUM CHLORIDE · GACl · GdmCl · GUANIDIUM CHLORIDE · AMINOFORMAMIDINE HCL · guanidiniumhydrochloride · GUANIDINE HYDROCHLORIDE 99%
Identifikatoren & physikalische Daten
| CAS No. | 50-01-1 |
|---|---|
| Summenformel | CH6ClN3 |
| Durchschnittliche Molmasse | 95,53 g/mol |
| SMILES | NC(N)=[NH2+].[Cl-] |
| InChIKey | PJJJBBJSCAKJQF-UHFFFAOYSA-N |
| PubChem CID | 5460839 |
| ChEBI | CHEBI:32735 |
| Lokaler Name | Guanidiniumchlorid |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 77,6 |
|---|---|
| H-Brücken-Donoren | 3 |
| H-Brücken-Akzeptoren | 1 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 5 |
| Formalladung | 0 |
| Komplexität | 18,8 |
| Schmelzpunkt | 180-185 °C(lit.) |
| Dichte | 1.18 g/mL at 25 °C(lit.) |
| Brechungsindex | n20/D 1.465 |
| Lagerbedingungen | room temp |
| Löslichkeit | H2O: 6 M, clear, colorless2280 g/L (20 ºC) |
| Aggregatzustand | Crystals |
| pKa (Säurekonstante) | 13.5(Temp: 27 °CSolvent: Water) |
| Farbe | White to slightly yellow |
| pH | 4.5-5.5 (100g/l, H2O, 20℃) |
| Geruch | Odorless |
| Biologische Quelle | synthetic (organic) |
| Merck | 14,4562 |
| BRN | 3591990 |
| Stabilität | Stable. Hygroscopic. Incompatible with strong oxidizing agents. |
| Kosmetik-Inhaltsstoffe Funktionen | BUFFERING |
| InChI | 1S/CH5N3.ClH/c2-1(3)4/h(H5,2,3,4)1H |
| InChIKey | PJJJBBJSCAKJQF-UHFFFAOYSA-N |
| SMILES | Cl[H].NC(N)=N |
| CAS Datenbank | 50-01-1(CAS DataBase Reference) |
| EPA chemische Informationen | Guanidine monohydrochloride (50-01-1) |
| Absorption | ≤0.10 at 260nm in H2O at 6M |
Sicherheit & Vorschriften
| F | 3-10 |
|---|---|
| Wassergefährdungsklasse (WGK) | 1 |
| TSCA-Inventar-Status | TSCA listed |
| Zollcode | 29252000 |
| RTECS-Nr. | MF4300000 |
| R-Sätze (R) | 22-36/38 |
| Toxizität | LD50 orally in Rabbit: 655.3 - 907.1 mg/kg LD50 dermal Rabbit > 2000 mg/kg |
| Gefahrensymbole | Xn,Xi |
| Sicherheitshinweise (S) | 26-36-22 |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrenklasse | Acute Tox. 4 InhalationAcute Tox. 4 OralEye Irrit. 2Skin Irrit. 2 |
Anwendungen & Verwendung
Verwenden
Guanidine hydrochloride is used for purification of proteins and nucleic acids. It can be used as a medicine, organic synthesis intermediate and is used in dyes. It acts as an intermediate in the preparation of sulfadiazine, which is an important raw material for sulfamethyldiazine, sulfamethazine and folic acid. It is utilized in the synthesis of 2-amino-pyrimidine, 2- amino -6- methyl-pyrimidine and 2-amino -4,6 - dimethyl-pyrimidine. Also used in RNA isolation to dissociate nucleoproteins and inhibit RNase.
Herstellung & Synthese
synthetische
The process for preparing guanidine hydrochloride is as follows:Step 1: Fritting - Combine dicyandiamide and ammonium chloride in a reactor with a 1:1.27 weight ratio and carry out a frit reaction at 170-230°C to obtain crude guanidine hydrochloride.Step 2: Dissolving - Dissolve the crude guanidine hydrochloride in water at a 1:1 ratio at normal temperature. Then, add ammonium salt alkaloid in an amount determined by the ammonium salt content in the crude guanidine hydrochloride.Step 3: Filtering - Remove raw materials and reaction by-products with filtration.Step 4: Dehydrating - Dehydrate the filtered ground mother liquor at a high temperature.Step 5: Crystallizing - Cool the supersaturated solution, concentrate, and crystallize to obtain high-purity guanidine hydrochloride.Step 6: Repeat steps 2-5 and add dicyandiamide in the reactor with the guanidine hydrochloride to carry out frit reaction at 170-230°C for 3-4 hours to obtain even higher purity guanidine hydrochloride. This step can be repeated several times if needed.Step 7: To obtain higher purity guanidine hydrochloride, subject the guanidine hydrochloride obtained in step 5 to steps 2-5 again, with the water ratio in step 2 adjusted to 1.5:1. This step can be repeated numerous times as required.