Dotmp Sm-153
Grundinformationen
- CAS
633308-21-1- Standard-SMILES
O=P([O-])(O)CN1CCN(CP(=O)([O-])O)CCN(CP(=O)(O)O)CCN(CP(=O)([O-])O)CC1.[153Sm+3]- InChIKey
LNBUCNBAQQFTBL-GJNDDOAHSA-K- Summenformel
- C12H29N4O12P4Sm
- Durchschnittliche Molmasse
- 698,2 g/mol
- Monoisotopische Masse
- 697,99535
Überblick
Samarium Sm 153-DOTMP is a radioconjugate composed of the phosphonic acid chelator DOTMP (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylenephosphonic acid) conjugated to the beta- and gamma-emitting radioisotope samarium Sm 153, with potential antineoplastic activity. Upon administration of samarium Sm 153-DOTMP, the DOTMP moiety targets and binds to growing bone, thereby selectively delivering samarium Sm 153-mediated cytotoxic radiation to bone tumor and metastases, which may help destroy bone metastases and mitigate pain from bone metastases.
Namen und Bezeichner
- Bevorzugter Name
- Dotmp Sm-153
- IUPAC
- [4,7-bis[[hydroxy(oxido)phosphoryl]methyl]-10-(phosphonomethyl)-1,4,7,10-tetrazacyclododec-1-yl]methyl-hydroxyphosphinate;samarium-153(3+)
Namen und Synonyme
Dotmp Sm-153Samarium-153 dotmpSamarate(5-)-153Sm, ((((1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl-kappaN1,kappaN4,kappaN7,kappaN10)tetrakis(methylene))tetrakis(phosphonato-kappaO))(8-))-, pentahydrogenSAMARATE(5-)-153SM, ((((1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAYL-.KAPPA.N1,.KAPPA.N4,.KAPPA.N7,.KAPPA.N10)TETRAKIS(METHYLENE))TETRAKIS(PHOSPHONATO-.KAPPA.O))(8-))-, PENTAHYDROGENRefChem:135709Samarium Sm 153-DOTMP153 Sm-DOTMP153SM-1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAMETHYLENE-PHOSPHONIC ACIDSm-153-1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetra(methylene)phosphonic AcidSm-153-1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayltetrakis(methylene)tetrakisphosphonic AcidCyclosam153Sm-Dotmp
Weitere Namen anzeigen
Sm-153-DotmpS5NN2E9ZKFUNII-S5NN2E9ZKF153Sm-1,4,7,10-Tetraazacyclododecane-1,4,7,10- tetramethylene-phosphonic acid633308-21-1
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 252 Ų
- H-Brücken-Donoren
- 5
- H-Brücken-Akzeptoren
- 16
- Frei drehbare Bindungen
- 8
- Schwere Atome
- 33
- Formalladung
- 0
- Komplexität
- 731
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