StartseiteMCPWorkbenchSkills
StartseiteWorkbenchBenachrichtigungenMein Bereich
Huagongshe Open Project:[email protected]KI-Anbindung: llms.txt · MCP-AnleitungDatenschutz · Nutzungsbedingungen · Supportv1.7.8
  1. Startseite
  2. /Verbindung

Pyrviniumembonat

Pyrvinium Pamoate

HCID 54680693
NotizenReaktionen
GrundinformationenÜberblickNamen und BezeichnerEigenschaftenSicherheit und RegulatorischesChemie und IndustrieZugehörige ReaktionenNotizen zur Verbindung
TeilstruktursucheÄhnliche Strukturen suchen

Grundinformationen

CAS
3546-41-6
Standard-SMILES
Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1.Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1.O=C(O)c1cc2ccccc2c(Cc2c([O-])c(C(=O)O)cc3ccccc23)c1[O-]
InChIKey
OOPDAHSJBRZRPH-UHFFFAOYSA-L
Summenformel
C75H70N6O6
Durchschnittliche Molmasse
1.151,4 g/mol
Monoisotopische Masse
1.150,53568397

Überblick

Pyrvinium pamoate appears as odorless bright orange or orange-red to brownish red or almost black fluffy powder. Melting point 210-215 °C. Insoluble in water. Tasteless.

Namen und Bezeichner

Bevorzugter Name
Pyrvinium Pamoate
IUPAC
3-carboxy-1-[(3-carboxy-2-oxidonaphthalen-1-yl)methyl]naphthalen-2-olate;bis(2-[(E)-2-(2,5-dimethyl-1-phenylpyrrol-3-yl)ethenyl]-N,N,1-trimethylquinolin-1-ium-6-amine)
Lokaler Name
Pyrviniumembonat
Englischer Name
PYRVINIUM PAMOATE
Summenformel
C75H70N6O6
Molmasse
1151.39

Namen und Synonyme

Pyrvinium pamoate3546-41-6DTXSID4023545Pyrvinium (as embonate)DTXCID503545VanquilPoquilRefChem:58631222-596-3310X6S84LW6-(Dimethylamino)-2-(2-(2,5-dimethyl-1-phenylpyrrol-3-yl)vinyl)-1-methylquinolinium 4,4'-methylenebis(3-hydroxy-2-naphthoate) (2:1)Alnoxin
Weitere Namen anzeigen
Pyrviniumtrupyrconpovanylmolevac
AltolatNSC-223622PamovinPovanPyrvinium 4,4'-methylenebis(3-hydroxynaphthalene-2-carboxylate)Pyrvinium embonateQuinolinium, 6-(dimethylamino)-2-(2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl)-1-methyl-, salt with 4,4'-methylenebis(3-hydroxy-2-naphthalenecarboxylic acid) (2:1)Quinolinium, 6-(dimethylamino)-2-(2-(2,5-dimethyl-1-phenylpyrrol-3-yl)vinyl)-1-methyl-, salt with 4,4'-methylenebis(3-hydroxy-2-naphthoic acid) (2:1)

Datenbank-Bezeichner

CAS
3546-41-6
PubChem CID
54680693

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
145 Ų
H-Brücken-Donoren
2
H-Brücken-Akzeptoren
8
Frei drehbare Bindungen
12
Schwere Atome
87
Formalladung
0
Komplexität
1.120

Experimentelle und physikochemische Eigenschaften

Solubilityless than 1 mg/mL at 75 °F (NTP, 1992)
Human Drugs · 2 Einträge

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Melting Point410 to 419 °F (NTP, 1992)
Physical DescriptionPyrvinium pamoate appears as odorless bright orange or orange-red to brownish red or almost black fluffy powder. Melting point 210-215 °C. Insoluble in water. Tasteless.

Physikochemische Eigenschaften

Schmelzpunkt
210 · 210-215° (softens at 190°)
Siedepunkt
829.27 °C · 829.27°C (rough estimate)
Dichte
1.0104 · 1.0104 (rough estimate)
Brechungsindex
1.64 · 1.6400 (estimate)
storage temp.
2 · 2-8°C
Löslichkeit
10 mg/mL · DMSO: >10mg/mL
Aggregatzustand
powder

Sicherheit und Regulatorisches

Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.

GHS-Klassifizierung

GHS Classification · 4 Einträge

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P203, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 40 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Other Safety InformationIMAP assessments - Quinolinium, 6-(dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-, salt with 4,4'-methylenebis[3-hydroxy-2-naphthalenecarboxylic acid] (2:1): Environment tier I assessment
Fire HazardsFlash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Health Hazards · 1 Eintrag

SYMPTOMS: Exposure to this compound may cause bright red stools, nausea, vomiting, diarrhea, allergic reactions and photosensitivity. It may cause irritation of the mucous membranes and upper respiratory tract. It may also cause kidney and liver injury after prolonged use.

Reactive GroupPhenols and Cresols
Reactivity ProfilePYRVINIUM PAMOATE is light sensitive. Incompatible with strong oxidizing agents, strong acids and bases (NTP, 1992).
Air and Water ReactionsInsoluble in water.
Hazard Classes and Categories

Chemie und Industrie

Pharmakologische Informationen

MeSH Pharmacological ClassificationAgents that kill parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.

Anwendungen

VerwendenPyrvinium Pamoate is a potent noncompetitive inhibitor of the androgen receptor, with the application towards prostate cancer treatment. Antihelmintic.

Anbieter77 Anbieter

国药集团化学试剂有限公司86-21-63210123 · [email protected]
苏州道澜生物医药科技有限公司15952404857 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
合肥曼奇诺生物医药技术有限公司19719236623 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
杭州品高化工有限公司0571-87658025 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
河南闰霖化工有限公司+86-18738066252; +86-18738066252 · [email protected]
Baoji Guokang Healthchem co.,ltd+8615604608665 15604608665 · [email protected]
北京索莱宝科技有限公司

Zugehörige Reaktionen

0
Reaktionsaufzeichnung erstellen

Keine Reaktionsaufzeichnungen unter den aktuellen Filterkriterien.

Notizen zur Verbindung

Wird geladen…

Auf dieser SeiteGrundinformationenÜberblickNamen und BezeichnerEigenschaftenSicherheit und RegulatorischesChemie und IndustrieZugehörige ReaktionenNotizen zur Verbindung
DTXSID
DTXSID4023545
ChEMBL
CHEMBL1908377
ChEBI
CHEBI:8688
EC Number
222-596-3
Farbe
red
InChIKey
OOPDAHSJBRZRPH-UHFFFAOYSA-L
EPA chemische Informationen
Pyrvinium pamoate (3546-41-6)
Acute Tox. 4 (100%)

Sicherheit und Schutzausrüstung

Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 Eintrag

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 Eintrag

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with 5% acetic acid, then transfer the dampened material to a suitable container. Use absorbent paper dampened with 5% acetic acid to pick up any remaining material. Your contaminated clothing and the absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with 5% acetic acid followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Personal Protective Equipment (PPE) · 1 Eintrag

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

Sicherheitsdaten

wgk
3
hs_code
2933492250
risk_code
20/21/22-36/37/38-40
hazard_code
Xn
safety_code
26-36
Speicherklasse
11 - Combustible Solids
Hazard Classifications
Acute Tox. 4 DermalAcute Tox. 4 InhalationAcute Tox. 4 OralCarc. 2Eye Irrit. 2Skin Irrit. 2STOT SE 3
010-50973130 17801761073 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
上海波以尔化工有限公司[email protected]
大连美仑生物技术有限公司0411-62910999 13889544652 · [email protected]
安耐吉化学&3A(安徽泽升科技有限公司)021-58432009 400-005-6266 · [email protected]
欧利希(湖北)医药科技有限公司17316404525 17316404525 · [email protected]
南京圣亿来化工有限公司19951936396 · [email protected]
United Life Science020-82099279 18988968278 · [email protected]
InvivoChem中国13549236410 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
常州市华阳科技有限公司+8615250961469 · [email protected]
MedChemexpress LLC021-58955995 · [email protected]
上海瀚香生物科技有限公司177-54423994 17754423994 · [email protected]
广东谦进化学试剂有限公司0751-2818792 13435114148 · [email protected]
ChemeGen 中国18818260767 · [email protected]
上海陶素生化科技有限公司021-33632979 · [email protected]
陕西缔都医药化工有限公司+86-029-81138252 +86-173 9270 1263 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
上海澄拓化工科技有限公司021-59904146 18001826933 · [email protected]
Chongqing jooe co., ltd+86-15223382610 · [email protected]
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司021-61415566 800-8193336 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
上海阿拉丁生化科技股份有限公司6206333 13167063860 · [email protected]
陕西缔都医药化工有限公司029-029-81120477 17792793610 · [email protected]
风咏生物(AbMole)021-10000000 13000000000 · [email protected]
上海珞珐生化科技有限公司021-51111890 15317326293 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
上海源叶生物科技有限公司18916372613 · [email protected]
上海珀法姆医药科技有限公司+86 18721201413 · [email protected]
爱必信(上海)生物科技有限公司13761418683 · [email protected]
Shanghai Acmec Biochemical Technology Co., Ltd.+86-18621343501 · [email protected]
杭州洁汉化工有限公司+86-571-86217390; +8618058761490 · [email protected]
中山市睿思生物技术有限公司13715524166 13326948089 · [email protected]
深圳市丽晶生化科技有限公司0755-85201366 18938635012 · [email protected]
江苏艾康生物医药研发有限公司025-66061636 19370895928 · [email protected]
丹东锦坤进出口有限公司+86-519-83607890 18921087080
艾览(上海)化工科技有限公司400-668-9898 · [email protected]
成都圣美凯生物科技有限公司028-85157043 15882256948 · [email protected]
北京沃凯生物科技有限公司010-62971590 18548936886 · [email protected]