Invertin

HCID 54684461CAS 17086-28-1
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Grundinformationen

Standard-SMILES
C[C@H]1c2cccc(O)c2C(O)=C2C(=O)[C@]3(O)C(O)=C(C(N)=O)C(=O)[C@@H](N(C)C)[C@@H]3[C@@H](O)[C@@H]21.O
InChIKey
XQTWDDCIUJNLTR-PGTYNCOMNA-N
Summenformel
C22H26N2O9
Durchschnittliche Molmasse
462,4 g/mol

Überblick

Doxycycline Monohydrate (internal use) can cause developmental toxicity according to state or federal government labeling requirements.

Namen und Bezeichner

Bevorzugter Name
Invertin
IUPAC
(4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrate
Englischer Name
Doxycycline monohydrate
Summenformel
C22H26N2O9
Molmasse
462.45

Namen und Synonyme

InvertinRefChem:791116DOXYCYCLINE MONOHYDRATE17086-28-1Doxycycline hydrateOraceaAdoxaMonodoxSupracyclinDoxirobeDoxylinXyrosa
Weitere Namen anzeigen
Doxycycline USPPower v1NSC-56228Strong v1Doxycyeline HCLoxycyclinemonohydrateDoxycycline Monohydrate (100 mg)Doxycycline monohydrate USP/EP/BP
VibramycinDoxycycline Hydrate (>90%)(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrateDoxycycline (monohydrate)MFCD02682958GS-3065(4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrateDoxiciclina

Datenbank-Bezeichner

CAS
17086-28-1、9001-57-4
PubChem CID
54684461
DTXSID
DTXSID401045241
ChEMBL
CHEMBL1200699
ChEBI
CHEBI:60648
UNII
N12000U13O
EC Number
605-591-4

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
183 Ų
H-Brücken-Donoren
7
H-Brücken-Akzeptoren
10
Frei drehbare Bindungen
2
Schwere Atome
33

Experimentelle und physikochemische Eigenschaften

DrugsPharmaceuticals -> Antibiotics

Physikochemische Eigenschaften

Schmelzpunkt
167 · 167-168℃
storage temp.
-20 °C · Sealed in dry,Store in freezer, under -20°C
Löslichkeit
1 mg/mL · DMSO: soluble1mg/mL
Aggregatzustand
powder or crystals
Farbe
Light Yellow
Wasserlöslichkeit
Soluble in ethanol or methanol. Sparingly soluble in water.Soluble in dilute acids, alkali hydroxides and dimethyl sulfoxide.

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Danger

H302 (43.2%): Harmful if swallowed [Warning Acute toxicity, oral]

P203, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 148 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory Information · 3 Einträge

Hazard Traits - Developmental Toxicity

Doxycycline monohydrate: Does not have an individual approval but may be used under an appropriate group standard

Invertin: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesAcute Tox. 4 (43.2%)

Sicherheitsdaten

wgk
3
hs_code
29413000
risk_code
36/37/38-22-63
hazard_code
Xi,Xn
safety_code
26-36/37
Speicherklasse
11 - Combustible Solids

Chemie und Industrie

Pharmakologische Informationen

FDA Pharmacological Classification · 2 Einträge

DOXYCYCLINE MONOHYDRATE

Tetracycline-class Drug [EPC]; Tetracyclines [CS]

Anwendungen · 2 Einträge

BeschreibungDoxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline. It is a semi-synthetic tetracycline. Doxycycline penetrates the bacterial cell and interferes with the protein biosynthesis, stopping the process. Other microorganisms are also sensitive to the antibiotic activity of Doxycycline, such as Mycoplasma, Chlamydia and Ricketsiae. Resistance to antibiotics of the tetracycline family is primarily due to inhibition of transport of the drug into the cell or by increasing antibiotic efflux. The biological mechanism is mainly through plasmid mediation but it may also occur by chromossomal alteration.

VerwendenDoxycycline Monohydrate is used to treat bacterial infections, Lyme disease, chlamydia, Rocky Mountain Spotted Fever, and other susceptible bacterial infections. It is an antibiotic with bacteriostatic properties.Tetracycline antibacterial.

Vor- und nachgelagerte Produkte

Anbieter50 Anbieter

湖南韵邦生物科技股份有限公司85561037 15386497078 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
湖北威德利化学试剂有限公司181-6332-1995 18062128043 · [email protected]
上海康朗生物科技有限公司021-61998208 18217752821 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]
Ergänzende Hinweise · 1 Eintrag

DefinitionChEBI: The monohydrate form of doxycycline. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary isease (COPD), and adult periodontitis.

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