Doxycycline hyclate
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Grundinformationen
- CAS
24390-14-5- Standard-SMILES
CCO.C[C@H]1c2cccc(O)c2C(O)=C2C(=O)[C@]3(O)C(O)=C(C(N)=O)C(=O)[C@@H](N(C)C)[C@@H]3[C@@H](O)[C@@H]21.C[C@H]1c2cccc(O)c2C(O)=C2C(=O)[C@]3(O)C(O)=C(C(N)=O)C(=O)[C@@H](N(C)C)[C@@H]3[C@@H](O)[C@@H]21.Cl.Cl.O- Summenformel
- C24H31ClN2O9
- Durchschnittliche Molmasse
- 526,97 g/mol
Namen und Bezeichner
- Bevorzugter Name
- Doxycycline hyclate
- Englischer Name
- Doxycycline hyclate
- Summenformel
- C24H31ClN2O9
- Molmasse
- 526.97
Namen und Synonyme
DOXYCYCLINE HYDRATEDoxycycline hyclate CRSDoxycycline HydrochlocideDoxycycline Hyclate Soluble PowderDoxycycline for system suitability CRSWC2031DoxycycLine hycLDoxycycline Hc1Doxycycline API
Datenbank-Bezeichner
- CAS
24390-14-5- PubChem CID
- 54686183
- UNII
- 19XTS3T51U
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 206 · 206-209C (dec.)
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- 2 O: · H2O: soluble50mg/mL
- Aggregatzustand
- Yellow to yellow-green crystalline solid
- Farbe
- yellow to greenish-yellow
- Biologische Quelle
- synthetic
- Wasserlöslichkeit
- 50 mg/ml · Soluble in water to 50mg/ml. May require warming.Soluble in water, methanol. Sparingly soluble in ethanol. Insoluble in chloroform and ether.
- Merck
- 14 · 14,3440
- BRN
- 5702728 · 5702728
- Major Application
- clinical testing
- InChIKey
- HALQELOKLVRWRI-VDBOFHIQSA-N
- SMILES
- C(O)C.O[C@@]12C(C(C(=O)N)=C(O)[C@@H](N(C)C)[C@]1([H])[C@H]([C@]1([H])[C@H](C3C=CC=C(O)C=3C(=O)C1=C2O)C)O)=O.Cl |&1:4,12,16,18,19,21,r|
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- hs_code
- 29413000
- risk_code
- 22-36/37/38
- Toxizität
- LD50 i.p. in rats: 262 mg/kg (Goldenthal)
- hazard_code
- Xn
- safety_code
- 26
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Acute Tox. 4 OralAquatic Chronic 3Eye Irrit. 2Repr. 2Skin Irrit. 2STOT SE 3
Chemie und Industrie
Anwendungen
BeschreibungDoxycycline Hyclate is the hyclate salt form of doxycycline, is a broad-spectrum tetracycline antibiotic. It inhibits bacterial protein synthesis by binding to ribosomes. Doxycycline also selectively inhibits human matrix metalloproteinase-8 (MMP-8) and MMP-13 over MMP-1 with 50, 60, and 5% inhibition, respectively, when used at a concentration of 30 μM. It can be used as a regulator for inducible gene expression systems where expression depends on either the presence (Tet-On) or absence (Tet-Off) of doxycycline. Formulations containing doxycycline have been used in the treatment of bacterial infections and the prevention of malaria.
VerwendenDoxycycline hyclate is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is used in the treatment of chlamydia, rickettsia, mycoplasma and some spirochete infections. It is also used to inhibit matrix metalloproteinases at subantimicrobial doses. Inhibits matrix metalloproteinases at subantimicrobial doses.
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国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
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