Tetracyclinhydrochlorid
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride (1:1), (4S,4aS,5aS,6S,12aS)-
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Grundinformationen
- CAS
64-75-5- Standard-SMILES
CN(C)[C@@H]1C(=O)C(C(N)=O)=C(O)[C@@]2(O)C(=O)C3=C(O)c4c(O)cccc4[C@@](C)(O)[C@H]3C[C@@H]12.Cl- InChIKey
XMEVHPAGJVLHIG-FMZCEJRJSA-N- Summenformel
- C22H25ClN2O8
- Durchschnittliche Molmasse
- 480,9 g/mol
- Monoisotopische Masse
- 480,1299435
Überblick
Tetracycline Hydrochloride (internal use) can cause developmental toxicity according to state or federal government labeling requirements.
Namen und Bezeichner
- Bevorzugter Name
- 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride (1:1), (4S,4aS,5aS,6S,12aS)-
- IUPAC
- (4S,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride
- Lokaler Name
- Tetracyclinhydrochlorid
- Englischer Name
- Tetracycline hydrochloride
- Summenformel
- C22H25ClN2O8
- Molmasse
- 480.9
Namen und Synonyme
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride (1:1), (4S,4aS,5aS,6S,12aS)-RefChem:476354TETRACYCLINE HYDROCHLORIDE64-75-5Tetracycline HClTetracycline.HClCycloparPanmycinSustamycinTetracynAchromycin hydrochlorideNeocycline b
Weitere Namen anzeigen
Tetracyclin HClsumycintetrachelcancycline-250amycin,hydrochloridealatet
Tetracycline (hydrochloride)Vetquamycin 324TopicyclineDTXSID6021321NSC-757338SupramycinQuatrex(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- Polarare Oberfläche (TPSA)
- 182 Ų
- H-Brücken-Donoren
- 7
- H-Brücken-Akzeptoren
- 9
- Frei drehbare Bindungen
- 2
- Schwere Atome
- 33
- Formalladung
- 0
- Komplexität
- 971
Experimentelle und physikochemische Eigenschaften
Collision Cross Section193.7 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physikochemische Eigenschaften
- Schmelzpunkt
- 220 · 220-223 °C(lit.)
- Brechungsindex
- -253 ° · -253 ° (C=0.5, 0.1mol/L HCl)
- storage temp.
- -20 °C · Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- Löslichkeit
- 2 O: · H2O: 10 mg/mL as a stock solution. Stock solutions should be filtered sterilized and stored at −20°C. Stable at 37°C for 4 days.
- Aggregatzustand
- powder
- pka
- 3.3 · 3.3 (pKa1)
- Farbe
- faint yellow to yellow
- PH
- pH(10g/l, 25℃) : 1.8～3.0
- Wasserlöslichkeit
- 50 g/L · 50 g/L
- Merck
- 14 · 14,9196
- BRN
- 3844873 · 3844873
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- F
- 8-10-23
- wgk
- 2
- tsca
- TSCA listed
- hs_code
- 29413000
- RTECS-Nr.
- QI9100000
- risk_code
- 36/37/38-20/21/22
- Toxizität
- LD50 orally in rats: 6443 mg/kg (Goldenthal)
- hazard_code
- Xi,Xn
- safety_code
- 26-36
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Aquatic Acute 1Aquatic Chronic 2Eye Irrit. 2Repr. 2Skin Irrit. 2STOT SE 3
Chemie und Industrie
Verwendung und Herstellung
General Manufacturing Information2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride (1:1), (4S,4aS,5aS,6S,12aS)-: ACTIVE
Anwendungen
BeschreibungTetracycline is a broad-spectrum antibiotic that prevents bacterial growth by inhibiting protein synthesis. It binds to a single site in the 30S ribosomal subunit which prevents attachment of aminoacyl tRNA to the ribosomal acceptor site. It is used in cell biology as a selective agent in cell culture systems. Tetracycline is toxic to prokaryotic and eukaryotic cells and selects for cells harboring the bacterial tetR gene, which are resistant to the antibiotic.
VerwendenTetracycline hydrochloride is a salt prepared from tetracycline taking advantage of the basic dimethylamino group which protonates and readily forms the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Tetracycline hydrochloride has broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-unit,s blocking protein synthesis.
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