Methyl 3-nitropropanoate

VerwendenMethyl 3-Nitropropanoate is used to nitroaldol additions, condensation reactions, and Michael additions involving the NO2-substituted carbon; the α-carbonyl carbon in dilithionitronate enolates of the esters undergoes alkylations, double alkylations, and aldol and Michael additions; elimination of HNO2 from the products gives α,β- unsaturated esters with substituents in either the β- or the α-position, thus making the reagent a synthetic equivalent of acrylate anions with d3 or d2 reactivity; precursor to nitrile oxide for [3 + 2] cycloadditions; 3-nitropropanoyl chloride can be used for enolate acylation and five-membered ring annulation.