HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Cefpirome
CEFPIROME SULPHATE · HR-810 · Keitim · CS-283 · CEFPIROME · Cefpiroma · Cefpiromum · Cerfpirome
Identifikatoren & physikalische Daten
| CAS No. | 84957-29-9 |
|---|---|
| Summenformel | C22H22N6O5S2 |
| Durchschnittliche Molmasse | 514,6 g/mol |
| Monoisotopische Masse | 514,1093098 g/mol |
| SMILES | CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[n+]3cccc4c3CCC4)CS[C@H]12)c1csc(N)n1 |
| InChIKey | DKOQGJHPHLTOJR-WHRDSVKCSA-N |
| PubChem CID | 5479539 |
| ChEMBL | CHEMBL65794 |
| ChEBI | CHEBI:3503 |
| DTXSID | DTXSID2048244 |
Chemische & physikalische Eigenschaften
| XLogP | 0,9 |
|---|---|
| Polarare Oberfläche (TPSA) | 207 |
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 10 |
| Frei drehbare Bindungen | 6 |
| Schwere Atome | 35 |
| Formalladung | 0 |
| Komplexität | 955 |
| Arzneimittel | Pharmaceuticals -> Antibiotics |
| Lagerbedingungen | 2-8°C(protect from light) |
Sicherheit & Vorschriften
| Drug Induced Liver Injury | Drug-Induced Liver Injury Severity and Toxicity (DILIst)CefpiromeDILI PositiveDOI:10.1016/j.drudis.2019.09.022 |
|---|---|
| R-Sätze (R) | 36/37/38-42/43 |
| Toxizität | LD50 in mice, rats (g/kg): 1.9-2.4, 1.9-2.15 i.v.3.8-4.2, 5.8-6.55 i.p. (Donaubauer, Mayer) |
| Gefahrensymbole | Xi |
| Sicherheitshinweise (S) | 22-26-36/37/39 |
Anwendungen & Verwendung
Beschreibung
This drug is resistant with respect to a broad spectrum of beta-lactamases. Its spectrum of activity is analogous to that of the third-generation cephalosporin cefotaxime (32.1.2.56), although it is more active with respect to some staphylococci, enterococci, and also a few enterobacteria. Synonyms of this drug are cefrom, cedixen, and others.
Verwenden
Cephalosporin antibiotic Claforan