Identifikatoren & physikalische Daten
| CAS No. | 72558-82-8 |
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| Summenformel | C22H22N6O7S2 |
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| Durchschnittliche Molmasse | 546,6 g/mol |
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| Monoisotopische Masse | 546,09913904 g/mol |
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| SMILES | CC(C)(O/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[n+]3ccccc3)CS[C@H]12)c1csc(N)n1)C(=O)O |
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| InChIKey | ORFOPKXBNMVMKC-DWVKKRMSSA-N |
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| PubChem CID | 5481173 |
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| ChEMBL | CHEMBL44354 |
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| ChEBI | CHEBI:3508 |
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| EC No. | 276-715-9 |
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| DTXSID | DTXSID5022770 |
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Chemische & physikalische Eigenschaften
| XLogP | 0,4 |
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| Polarare Oberfläche (TPSA) | 245 |
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| H-Brücken-Donoren | 3 |
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| H-Brücken-Akzeptoren | 12 |
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| Frei drehbare Bindungen | 8 |
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| Schwere Atome | 37 |
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| Formalladung | 0 |
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| Komplexität | 1.020 |
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| Stoffklassen | Other Uses -> Pharmaceuticals |
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| Arzneimittel | Pharmaceuticals -> Antibiotics |
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| LogP (Verteilungskoeffizient) | -1.60 |
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| Löslichkeit | 5.73e-03 g/L |
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| Human Drugs | Breast FeedingLactationAnti-Infective AgentsAntibacterial AgentsCephalosporinsMilk, HumanFDA approved drugs -> Active ingredientWatch group antibiotics |
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| Schmelzpunkt | 103-113 |
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| Physical Description | Solid |
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Sicherheit & Vorschriften
| GHS-Einstufung | DangerH300 (17.5%): Fatal if swallowed [Danger Acute toxicity, oral]P233, P260, P261, P264, P270, P271, P272, P280, P284, P301+P316, P302+P352, P304+P340, P321, P330, P333+P317, P342+P316, P362+P364, P403, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 80 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
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| Regulatorische Informationen | Ceftazidime: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right. |
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| Gefahrenübersicht | May cause allergic skin reaction and asthma[Pfizer] Occupational asthma confirmed in a pharmaceutical worker[Malo] |
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| Hazard Classes and Categories | Acute Tox. 1 (17.5%) |
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| Unerwünschte Wirkungen | Asthma - Reversible bronchoconstriction (narrowing of bronchioles) initiated by the inhalation of irritating or allergenic agents. |
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| Drug Induced Liver Injury | Drug Induced Liver Injury Rank (DILIrank 2.0)CeftazidimevLess-DILI-concern3Adverse reactionsDOI:10.1016/j.drudis.2016.02.015 |
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| Effects During Pregnancy and Lactation | ◉ Summary of Use during Lactation |
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