Tolnaftate

HCID 5510
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Grundinformationen

CAS
2398-96-1
Standard-SMILES
Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1
InChIKey
FUSNMLFNXJSCDI-UHFFFAOYSA-N
Summenformel
C19H17NOS
Durchschnittliche Molmasse
307,4 g/mol
Monoisotopische Masse
307,10308516

Überblick

Crystals or white powder. (NTP, 1992)

Namen und Bezeichner

Bevorzugter Name
Tolnaftate
IUPAC
O-naphthalen-2-yl N-methyl-N-(3-methylphenyl)carbamothioate
Englischer Name
Tolnaftate
Summenformel
C19H17NOS
Molmasse
307.41

Namen und Synonyme

tolnaftate2398-96-1TolnaphthateTinactinSporilineTinadermTolsanilDermoxinFocusanAftatePitrexNaphthiomate T
Weitere Namen anzeigen
TOLNAFTATE USPTolnaflatesorgoaTinavetnaftate
PhytodermTolnaftatoTimopedTritinHI-AlazinTolnaftatumSeparinSch 10144

Datenbank-Bezeichner

CAS
2398-96-1
PubChem CID
5510
DTXSID
DTXSID3042477
ChEMBL
CHEMBL83668
ChEBI
CHEBI:9620
UNII
06KB629TKV
EC Number
219-266-6
Nikkaji
J4.423G

Eigenschaften

Berechnete Struktureigenschaften

XLogP
5,5
Polarare Oberfläche (TPSA)
44,6 Ų
H-Brücken-Donoren
0
H-Brücken-Akzeptoren
2
Frei drehbare Bindungen
3
Schwere Atome
22

Experimentelle und physikochemische Eigenschaften

Drugs · 2 Einträge

Pharmaceuticals -> Listed in ZINC15

Pharmaceuticals

SpringerMaterials PropertiesFusion temperature
LogP5.31
Solubilityless than 1 mg/mL at 72 °F (NTP, 1992)
Human DrugsBreast Feeding; Lactation; Milk, Human; Anti-Infective Agents; Antifungal Agents
Animal DrugsActive Ingredients (Tolnaftate) -> FDA Greenbook

Physikochemische Eigenschaften

Schmelzpunkt
110.5 · 110.5-111.5°C
Siedepunkt
453.4 · 453.4±38.0 °C(Predicted)
Dichte
1.1328 · 1.1328 (rough estimate)
Brechungsindex
1.697 · 1.6970 (estimate)
storage temp.
2 · Sealed in dry,2-8°C
Löslichkeit
50 mg/ml · Soluble in chloroform at 50 mg/ml. Sparingly soluble in ethanol or methanol

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 5 Einträge

This chemical does not meet GHS hazard criteria for 40.4% (38 of 94) of reports.

Warning

H319 (56.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

P264+P265, P273, P280, P305+P351+P338, P337+P317, P391, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 94 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory InformationTolnaftate: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Carbamothioic acid, methyl(3-methylphenyl)-, O-2-naphthalenyl ester: Human health tier I assessment
Fire HazardsFlash point data on this chemical are not available, it is probably combustible. (NTP, 1992)
Health HazardsSYMPTOMS: In susceptible persons, this compound may cause sensitization or irritation. (NTP, 1992)
Reactive GroupThiocarbamate Esters and Salts/Dithiocarbamate Esters and Salts
Reactivity Profile · 1 Eintrag

TOLNAFTATE is a thiocarbamate. Flammable gases are generated by the combination of thiocarbamates and dithiocarbamates with aldehydes, nitrides, and hydrides. Thiocarbamates and dithiocarbamates are incompatible with acids, peroxides, and acid halides.

Sicherheit und Schutzausrüstung

Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 Eintrag

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 Eintrag

SMALL SPILLS AND LEAKAGE: If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Personal Protective Equipment (PPE) · 1 Eintrag

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Toxikologische Informationen

Effects During Pregnancy and Lactation◉ Summary of Use during Lactation

Sicherheitsdaten

wgk
2
tsca
TSCA listed
hs_code
2930206050
RTECS-Nr.
FD8891300
Toxizität
LD50 in mice, rats (g/kg): >10, >6 orally; >6, >4 s.c. (Hashimoto)
hazard_class
IRRITANT

Chemie und Industrie

Pharmakologische Informationen

ATC Code · 2 Einträge

D - Dermatologicals

QD - Dermatologicals

PharmacodynamicsTolnaftate is a synthetic over-the-counter anti-fungal agent.
Mechanism of Action · 1 Eintrag

Tolnaftate is a topical fungicide. Though its exact mechanism unknown, it is believed to prevent ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms.

FDA Pharmacological Classification · 4 Einträge

TOLNAFTATE

Azole Antifungal [EPC]; Azoles [CS]

ANTIFUNGAL POWDER SPRAY

Azoles [CS]; Azole Antifungal [EPC]

MeSH Pharmacological ClassificationSubstances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
Cellular LocationsMembrane

Verwendung und Herstellung

UsesUse (kg; approx.) in Germany (2009): >50
Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
General Manufacturing InformationCarbamothioic acid, N-methyl-N-(3-methylphenyl)-, O-2-naphthalenyl ester: ACTIVE
Anwendungen · 2 Einträge

BeschreibungTolnaftate is a thiocarbamate antifungal agent. It is active against clinical isolates of the dermatophytes T. rubrum, T. mentagraphytes, T. verrucosum, E. floccosum, and M. canis (MIC50s = 50, 100, 6, 50, and 50 ng/ml, respectively), as well as 18 additional yeast and filamentous fungi species (MIC = 0.003-0.8 μg/ml)., Tolnaftate also reduces aflatoxin production in A. parasiticus in a concentration-dependent manner. It inhibits squalene epoxidase with an IC50 value of 12.5 μg/ml in a cell-free assay.

Verwendenantifungal for cutaneous infections. Tolnaftate (Aftate, Tinactin, etc.) is an odorless and nonstaining synthetic antifungal agent whose exact mechanism of action is unknown. It is effective against dermatophytes and P. orbiculare and Pityrosporum ovale. It is ineffective against C. albicans and bacteria.

Vor- und nachgelagerte Produkte

Anbieter100 Anbieter

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
郑州阿尔法化工有限公司+86-18530059196 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

Ergänzende Hinweise

DefinitionChEBI: A monothiocarbamic ester that is the methyl(3-tolyl)carbamothioate ester of 2-naphthol. A synthetic anti-fungal agent used to treat jock itch, athlete's foot and ringworm.

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